Risk Factors of Graft-Versus-Host Disease in the Iranian Allogeneic Hematopoietic Stem Cell Transplantation: A 10-Year Experience

Mehdizadeh, Mahshid; Parkhideh, Sayeh; Salari, Sina; Roshandel, Elham; Kazemi, Mohammad; Bonakchi, Hossein; Soleimani, Masoud; Hajifathali, Abbas

doi:10.47176/mjiri.35.145

Cited by 2 publications

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“…Graft-versus-host disease (GVHD) is the Main Reason of Non-relapse mortality and morbidity after allogeneic hematopoietic stem cell transplantation (allo-HSCT) (1). According to properties of donors and recipients, human leukocyte antigen (HLA) compatibility, GVHD prophylaxis, and conditioning regimen, acute GVHD (aGVHD) approximately occurs in 30 -50% of allo-HSCT patients (2,3). In aGVHD, tissue damage is generally caused by T helper (TH)1 and TH17 cells and innate immune system cells such as natural killer (NK) cells (4).…”

Section: Introductionmentioning

confidence: 99%

Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2022

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Background: T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune-checkpoint molecule that is upregulated following allogeneic immune responses and could play an important role in the development and pathogenesis of graft-versus-host disease (GVHD). The soluble form of TIM-3 (sTIM-3) is increased following the upregulation of membranous TIM-3. Objectives: The aim of this study was to evaluate the association between plasma level of sTIM-3 and acute GVHD (aGVHD) incidence in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Blood samples were collected from 42 allo-HSCT patients and 20 healthy individuals 2 weeks after allo-HSCT. The plasma level of sTIM-3 was measured using enzyme-linked immunosorbent assay (ELISA). The clinical and demographic data of patients were collected from the clinical documents. Data analysis was evaluated using student t-test and one-way ANOVA tests. P-values less than 0.05 were assumed statistically significant. Results: Among 18 (42.8%) patients with aGVHD symptoms, 10 (23.8%) had severe GVHD and 8 (19%) experienced mild GVHD. Plasma sTIM-3 levels at day +14 were significantly higher in patients who developed aGVHD compared to allo-HSCT patients without GVHD and also the healthy control individuals (P-value = 0.015 and < 0.001). Among the aGVHD patients, the sTIM-3 levels in those with severe GVHD were approximately 2.5 times higher than those with mild GVHD (P-value < 0.001). Conclusions: We have identified a high plasma level of sTIM-3 as a valuable biomarker in predicting the development of acute GVHD, especially severe aGVHD in allo-HSCT patients.

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Section: Introductionmentioning

confidence: 99%

Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2022

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Fecal Calprotectin: A Predictive Biomarker for Gastrointestinal Graft-versus-Host-Disease and a Prognostic Indicator in their Steroid therapy

Roshandel,

Parkhideh,

Mohammadian

et al. 2024

Ann. Cancer Res. Therap.

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Risk Factors of Graft-Versus-Host Disease in the Iranian Allogeneic Hematopoietic Stem Cell Transplantation: A 10-Year Experience

Abstract: Background transplantation some risk factoMethods: W disorders who analyses of tim level of statistic Results: Acu odds of GVHD p<0.001). The BMI above 30 antigen was 76 Conclusion: infection/reacti GVHD.

Cited by 2 publications

References 40 publications

Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

Fecal Calprotectin: A Predictive Biomarker for Gastrointestinal Graft-versus-Host-Disease and a Prognostic Indicator in their Steroid therapy

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