Risk factors of prognosis after acute kidney injury in hospitalized patients

Nie, Sasa; Feng, Zhe; Xia, Lihua; Bai, Jiuxu; Xiao, Fenglin; Liu, Jian; Li, Tang; Chen, Xiangmei

doi:10.1007/s11684-017-0532-9

Cited by 16 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 36 ] Thrombocytopenia has also been associated with AKI and mortality in non-surgical settings. [ 37 , 38 ] Nonetheless, thrombocytopenia is also a marker for critically ill patients and may reflect an underlying disease. [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

et al. 2018

View full text Add to dashboard Cite

BackgroundSurgery is one of the leading causes of acute kidney injury (AKI) in hospitalized patients. Major abdominal surgery has the second higher incidences of AKI, after cardiac surgery. AKI results from a complex interaction between hemodynamic, toxic and inflammatory factors. The pathogenesis of AKI following major abdominal surgery is distinct from cardiac and vascular surgery. The neutrophil, lymphocytes and platelets (N/LP) ratio has been demonstrated as an inflammatory marker and an independent predictor for AKI and mortality after cardiovascular surgery. The aim of this study was to evaluate the prognostic ability of the post-operative N/LP ratio after major abdominal surgery.MethodsWe cross-examined data of a retrospective analysis of 450 patients who underwent elective or urgent major nonvascular abdominal surgery at the Department of Surgery II of Centro Hospitalar Lisboa Norte from January 2010 to February 2011. N/LP ratio was determined using maximal neutrophil counts and minimal lymphocyte and platelet counts in the first 12 h after surgery. AKI was considered when developed within 48 h after surgery.ResultsOne-hundred and one patients (22.4%) developed AKI. Patients with higher N/LP ratio had an increased risk of developing postoperative AKI (6.36 ± 7.34 vs 4.33 ± 3.36, p < 0.001; unadjusted OR 1.1 (95% CI 1.04–1.16), p = 0.001; adjusted OR 1.05 (95% CI 1.00–1.10), p = 0.048). Twenty-nine patients died (6.44%). AKI was an independent predictor of mortality (20.8 vs 2.3%, p < 0.0001; unadjusted OR 11.2, 95% CI 4. 8-26.2, p < 0.0001; adjusted OR 3.56, 95% CI 1.0 2-12.43, p = 0.046). In a multivariate analysis higher N/LP ratio was not associated with increased in-hospital mortality.ConclusionPostoperative N/LP ratio was independently associated with AKI after major abdominal surgery, although there was no association with in-hospital mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

et al. 2018

View full text Add to dashboard Cite

show abstract

“…hypoalbuminemia was found to be the major risk coefficient that affected the prognosis of older patients with AKI (80–100 years old) undergoing continuous renal replacement therapy (CRRT), and was related to the turnover of these patients.These results showed that malnutrition is one of the main causes of death and albumin is a predictor for the mortality of critically ill older patients with AKI. In the study of Nie et al15 it was found that albumin, BMI, total blood count of white blood cell, and total blood count of platelets were the predictors of mortality of AKI patients. Albumin belongs to the biomarkers of malnutrition and total blood count of white blood cell is a biomarker of inflammation.…”

Section: Discussionmentioning

confidence: 98%

<p>Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?</p>

Gong¹,

Ding²,

Gu³

2019

CIA

View full text Add to dashboard Cite

BackgroundCritically ill older patients with acute kidney injury (AKI), also referred to as acute renal failure, are associated with high in-hospital mortalities. Preexisting malnutrition is highly prevalent among AKI patients and increases in-hospital mortality rate. This study is to evaluate the predictive power of some serum nutritional related biomarkers predicting the 90 days in-hospital mortality of critically ill older patients with AKI.MethodsA prospective, observational study was conducted in a university teaching hospital. One hundred and five critically ill older patients with AKI aged 60–95 were enrolled and were divided into survival group (n=44) and non-survival group (n=61) in the light of their final outcomes. Receiver operating characteristic analyses (ROC) were performed to calculate the area under ROC curve (AUC). Sensitivity and specificity of in-hospital mortality prediction were calculated.ResultsSignificant differences were found between the survival group and non-survival group of critically ill older patients with AKI. AUC of low density lipoprotein (LDL) and albumin were 0.686 and 0.595, respectively. The asymptotic 95% confidence intervals of LDL and albumin were 0.524–0.820 and 0.488–0.696, respectively. Sensitivity of the 90 days in-hospital mortality prediction of LDL and albumin were 68.71% and 69.09%, respectively. Specificity of 90 days in-hospital mortality prediction of LDL and albumin were 69.23% and 50.0%, respectively.ConclusionLDL and albumin did not have sufficient power to predict the 90 days in-hospital mortality of critically ill older patients with AKI. Further research on the association between malnutrition and poor prognosis of critically ill older patients with AKI is needed in the future.Trial registration: ClinicalTrials.gov identifier: NCT00953992.

show abstract

“…Patient comorbidities such as diabetes mellitus, hypertension, cardiovascular disease, chronic liver disease, and chronic obstructive pulmonary disease have also been identified as important AKI predictors [ 11 , 13 , 36 , 37 , 40 , 45 , 46 ]. Given the increasing incidence of HIV-infected patients in past few decades, HIV infection is also a risk factor that predisposes patients to AKI [ 47 , 48 ].…”

Section: Risk Factors For Akimentioning

confidence: 99%

Acute Kidney Injury: From Diagnosis to Prevention and Treatment Strategies

Gameiro

Fonseca

Outerelo

et al. 2020

JCM

View full text Add to dashboard Cite

Acute kidney injury (AKI) is characterized by an acute decrease in renal function that can be multifactorial in its origin and is associated with complex pathophysiological mechanisms. In the short term, AKI is associated with an increased length of hospital stay, health care costs, and in-hospital mortality, and its impact extends into the long term, with AKI being associated with increased risks of cardiovascular events, progression to chronic kidney disease (CKD), and long-term mortality. Given the impact of the prognosis of AKI, it is important to recognize at-risk patients and improve preventive, diagnostic, and therapy strategies. The authors provide a comprehensive review on available diagnostic, preventive, and treatment strategies for AKI.

show abstract

Risk factors of prognosis after acute kidney injury in hospitalized patients

Cited by 16 publications

References 29 publications

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

Neutrophil, lymphocyte and platelet ratio as a predictor of postoperative acute kidney injury in major abdominal surgery

<p>Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?</p>

Acute Kidney Injury: From Diagnosis to Prevention and Treatment Strategies

Contact Info

Product

Resources

About