Risk for Clostridium difficile infection after radical cystectomy for bladder cancer: Analysis of a contemporary series

Liu, Nick W.; Shatagopam, Kashyap; Monn, M. Francesca; Kaimakliotis, Hristos Z.; Cary, Clint; Boris, Ronald S.; Mellon, Matthew J.; Masterson, Timothy A.; Foster, Richard S.; Gardner, Thomas A.; Bihrle, Richard; House, Michael G.; Koch, Michaël

doi:10.1016/j.urolonc.2015.07.007

Cited by 24 publications

(17 citation statements)

References 30 publications

(39 reference statements)

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“…It has been demonstrated that the development of CDI after cystectomy is associated with a 2.5-fold increase in mortality and adds approximately $22,634 in cost per hospitalization per patient 17 . Our institution's CDI incidence from 2010 to 2013 was closer to the high end of this range as reported in 2015 19 . The incidence of asymptomatic CD carriage is unfortunately unknown in cystectomy patients.…”

Section: Introductionsupporting

confidence: 78%

“…CDI rates on other floors, including medical and colorectal surgical wards, demonstrated a less pronounced rate of CDI reduction ranging from 5 to 33%. The generalizability of our results may be limited due to the higher incidence rate of CDI compared to other institutions [16][17][18][19] . However, CDI rates are rising and recent reports suggest that CDI rates in cystectomy patients may be even higher at other institutions 5,20 .…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 85%

“…Cystectomy patients are at higher risk of CDI than the general patient population due to their increased age, underlying comorbidities, and recent antibiotic exposure with published rates of CDI in cystectomy patients ranging from 1.4-14% [16][17][18][19][20][21] . It has been demonstrated that the development of CDI after cystectomy is associated with a 2.5-fold increase in mortality and adds approximately $22,634 in cost per hospitalization per patient 17 .…”

Section: Introductionmentioning

confidence: 99%

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A Prospective Program to Reduce the Clinical Incidence of Clostridium difficile Colitis Infection after Cystectomy

et al. 2019

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Section: Introductionsupporting

confidence: 78%

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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A Prospective Program to Reduce the Clinical Incidence of Clostridium difficile Colitis Infection after Cystectomy

et al. 2019

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“…[7,9,29–31] Although RC is a risk factor for CDAD in various urological surgeries, [32] our results show a relatively high incidence of CDAD. However, some investigations examined the trends toward higher incidence rates of C difficile infection in studies with medical record review [30,31] than in studies using claim data or nationwide sample data, [9,29] which have a probable reporting bias. Our results regarding the incidence of C difficile infection were comparable to those of previous studies that directly reviewed the medical records of patients with RC.…”

Section: Discussionmentioning

confidence: 76%

Impact of a change in duration of prophylactic antibiotics on infectious complications after radical cystectomy with a neobladder

Kim¹,

Kim

Song

et al. 2018

Medicine

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A profound number of prophylactic antibiotics are used after radical cystectomy with an ileal orthotopic neobladder (RCIONB) despite a negative effect of infection control. We investigated the impact of short-term prophylactic antibiotic use on infectious complications after RCIONB. We retrospectively reviewed data from 287 patients who underwent RCIONB for bladder cancer between 2012 and 2016 at a tertiary hospital. The patients were divided into 2 groups according to the pattern of prophylactic antibiotics (185 patients in a long-term group, 25-day use of 3-staged multiple antibiotics versus 102 patients in a short-term group, 24-hour use of cefotetan). The onset of complications, including bacteriuria, febrile urinary tract infection (FU), and bacteremia, and the microorganisms responsible for infections were compared between the groups. Of all 287 patients, bacteriuria, FU, and bacteremia were identified in 177 (61.7%), 85 (29.6%), and 18 (6.3%) patients, respectively. Bacteriuria was identified more frequently in the short-term group (49.2% vs 84.3%, P <.001). However, the rates of FU within 60 days of surgery were similar in both groups (28.6% vs 28.4%, P = .969). The rate of FU was not significantly different between the 2 groups. There was no significant difference in the rate of patients with bacteremia (5.4% vs 7.8%, P = .415). The most frequent microorganisms seen in bacteriuria were Enterococcus faecium and Enterococcus faecalis , in the long-term and short-term group, respectively. Antibiotic-resistant Enterococcus species were more frequently present in the long-term group. Short-term use of prophylactic antibiotics is effective for preventing urinary tract infections after RCIONB and decreasing colonization with multi-drug-resistant organisms.

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“…Inappropriate use of antibiotics may cause a variety of adverse effects, including serious complications such as allergic reactions, organ dysfunction, or Clostridioides difficile infection [34][35][36][37][38][39]. Perhaps most concerning is that self-medication infers self-diagnosis, significantly increasing the risk for delayed, masked, or missed diagnoses [40].…”

Section: Plos Onementioning

confidence: 99%

Online availability of fish antibiotics and documented intent for self-medication

et al. 2020

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Self-medication and antibiotic utilization without healthcare oversight may lead to delayed appropriate treatment, transmission of communicable infections, untoward adverse events, and contribute to antimicrobial resistance. Previous data suggest people obtain over-the-counter (OTC) animal antibiotics for their personal use. This study examined the availability of OTC fish antibiotics online and the documented intent for self-medication. The authors conducted a web-based cross-sectional study using Google search engine to identify vendor websites selling fish antibiotics in the United States. Vendor websites were included if product information, consumer reviews, and comments were publicly available. Nine fish antibiotics were chosen due to their possibility of having consequences to human misuse. The cost and availability of fish antibiotics was recorded. The proportion of reviews and comments related to human consumption was calculated. Consumer review traffic based on "likes" and "dislikes" received was compared between human-and non-human consumption-related reviews. Selected fish antibiotics were purchased and evaluated for physical appearance and compared to FDA-approved available equivalents. We found 24 website vendors with online ordering available for OTC fish antibiotics. Cost varied significantly by antibiotic and quantity ranging from USD $8.99 to $119.99. There were 2,288 reviews documented for the 9 selected antibiotics being sold. Among consumer reviews, 2.4% were potentially associated with human consumption. Human consumption-related reviews constituted 30.2% of all "likes" received and 37.5% of all "dislikes" received. Human consumption-related reviews received an average of 9.2 likes compared to 0.52 likes for non-human consumption-related reviews. The 8 fish antibiotics purchased were consistent with FDA-approved equivalents in physical appearance. Although infrequent, antibiotics intended for fish use are being purchased online without a prescription for self-medication to circumvent professional medical care.

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Risk for Clostridium difficile infection after radical cystectomy for bladder cancer: Analysis of a contemporary series

Abstract: Introduction: This study seeks to evaluate the incidence and associated risk factors for

Cited by 24 publications

References 30 publications

A Prospective Program to Reduce the Clinical Incidence of Clostridium difficile Colitis Infection after Cystectomy

A Prospective Program to Reduce the Clinical Incidence of Clostridium difficile Colitis Infection after Cystectomy

Impact of a change in duration of prophylactic antibiotics on infectious complications after radical cystectomy with a neobladder

Online availability of fish antibiotics and documented intent for self-medication

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