The article is concerned with solving the problem of ensuring sustainable development at the level of enterprise as determined by the UN, which is relevant not only at the local level of Ukraine, but also world-wide. The article is aimed at theoretical substantiating the hypothesis on the existence of a connection between sustainable development of enterprises and basic unconditional income (BUI) using general scientific methods of critical and logical analysis and synthesis, ascent from abstract to specific, abstraction. The BUI in the research is understood as regular cash payments in the amount of the real subsistence minimum to citizens of the State, regardless of their socio-economic status. It is substantiated that BUI is the socio-economic regulator of sustainable development of the region and at the same time an instrument for sustainable development of the enterprise to achieve social, economic and ecological balance. It is proposed to consider BUI as an integrating instrument for sustainable development of enterprises and regions, which will provide a vertical link between the goals and objectives of sustainable development to overcome poverty, hunger, opening access to education and self-development at the meso- and micro levels. The example of depressed economically mono structural mining regions and mining enterprises of Ukraine to be liquidated displays the complex impact of BUI on their sustainable development through the component of social development. A comparison of development in the presence and absence of BUI is made and it is identified that the BUI will allow to «mitigate» economic restructuring, level territorial differentiation, implement the policy of social corporate responsibility and public-private partnership at the enterprise. The question has been raised about which economic agent should ensure the payment of BUI: the region or the enterprises operating in the region and using resources that could be saved for future generations. It is proposed to consider the possibility of payment of BUI both from the budget of the region and from the funds of enterprises.