Risk Management of Osteoporosis in Postmenopausal Women; A Study of Women In a Teaching Hospital

Lohana, Chander Kumar; Samir, Nafisa

doi:10.5539/gjhs.v8n11p36

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…The surface of ovarian tissue granulosa cells also express the MT receptor, which indicates that MT can directly regulate ovarian function through a variety of ways. Findings have shown that in many patients with POF, ROS participate in normal follicular development at each physiological stage including: Folliculogenesis and atresia, ovulation, oocyte maturation, and corpus luteum formation (10). MT and its metabolites are considered to be potent antioxidants and free radical scavengers which prevent POF.…”

Section: Discussionmentioning

confidence: 99%

Effect of melatonin on the peripheral T lymphocyte cell cycle and levels of reactive oxygen species in patients with premature ovarian failure

Liu

Sun

et al. 2016

Experimental and Therapeutic Medicine

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The objective of the present study was to observe the curative effect and mechanism of melatonin for suppression of premature ovarian failure (POF). From December 2014 to June 2015, 128 patients were consecutively diagnosed with POF in the Department of Gynaecology and Obstetrics. The patients were randomly divided into the experimental and control groups. The experimental group received melatonin tablets (1–3 mg/day), while the control group received placebo tablets. The levels of six sex hormones, percentage of T lymphocytes in the G1/M phase, and levels of reactive oxygen species (ROS) were determined at four different time-points (1 day before treatment, and at 1, 3 and 6 months after treatment) in both groups. After 6 months of treatment, the levels of luteinizing hormone and follicle-stimulating hormone were significantly decreased in the experimental group compared with the control group (P<0.05). Compared with the control group, the levels of ROS in plasma were significantly decreased in the experimental group (P<0.05). Correlation analysis showed that the levels of melatonin in peripheral blood were negatively related with the levels of ROS (rs=−0.481, P<0.05). One-year follow-up study showed that the normal excretion of ovarian hormones in the experimental group was significantly higher than that of the control group (P<0.05). In conclusion, treatment with melatonin is an effective approach to suppress POF. The potential mechanism of melatonin is inhibition of ROS production and protection of the process of normal follicle development.

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Section: Discussionmentioning

confidence: 99%

Effect of melatonin on the peripheral T lymphocyte cell cycle and levels of reactive oxygen species in patients with premature ovarian failure

Liu

Sun

et al. 2016

Experimental and Therapeutic Medicine

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“…13 In 2003, Cheng S et al in their study found that BMD was significantly higher in non-hysterectomised women when compared with hysterectomised women with a p value of 0.001. 14 Gopinath RV et al in their study found that BMD in nonhysterectomised women was 753.36±176.2 g/cm 2 compared to 973.2±108.28 g/cm 2 . It showed significant higher BMD in non-hysterectomised group with a p value of <0.05.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of osteoporosis in hysterectomised as compared to non-hysterectomized women in 7th decade of life

Shamim

Lal

Shamim³

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Osteoporosis is considered as a major public health issue with fragility fractures of the hip, vertebrae and distal radius being the most important consequences. It has been said to be an age-related degenerative process. However, postmenopausal women develop this disease due to age-related bone mineral loss as well as due to declining levels of estrogen in the body following menopause leading to increased risk of fractures. Objectives of this study were to find out the prevalence of osteoporosis in hysterectomised and non-hysterectomised postmenopausal women in 7th decade of life.Methods: Descriptive cross-sectional study done on a total of 66 postmenopausal women who were in their 7th decade of life. They were divided into two groups, one consisting of 36 women who underwent natural menopause and the other group of 30 women who had surgical menopause. The bone mineral density of both the groups was measured using DEXA scan and comparison was done between these study groups.Results: Out of 30 hysterectomised subjects, 24 (80%) were found to be having osteoporosis, 6 (20%) had osteopenia and none had normal BMD. While out of 36 subjects in the non-hysterectomised group, 14 (38.88%) had osteoporosis, 16 (44.44%) had osteopenia and 6 (16.66%) subjects had normal BMD. Significant relation (p-value 0.001) was found on comparison of the study groups. In addition, significant positive correlation was between BMD and BMI whereas negative correlation was seen between BMD and parity.Conclusions: Hysterectomy was found to increase the incidence of osteoporosis. Obesity was found to have protective effect against bone mineral loss while increasing parity had a negative relation with BMD.

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“…This leads to increased bone fragility and a significantly higher risk of fractures [1,2] . Measuring bone mineral density (BMD) is crucial for early detection of osteoporosis, enabling prompt implementation of effective preventative and therapeutic interventions [3][4][5] . The Human Genome Project is anticipated to uncover early signals of vulnerability to complex diseases using genetic data.…”

Section: Introductionmentioning

confidence: 99%

The study evaluated the ZBTB40 gene polymorphism and biochemical parameters in women suffering from osteoporosis

Juhi,

Gabber,

Hassan

2024

Int. J. Adv. Chem. Res.

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Osteoporosis weakens bones. Falling or bumping increases the risk of bone fracture. Due to its lack of symptoms, many people are unaware they have it until they fracture. Bone mineral density testing is a safe, fast, and painless approach to detect osteoporosis or its risk. Spine fractures are diagnosed using traditional X-rays, which cannot measure bone mineral density. Specialized procedures are needed to assess bone mineral density. Multiple bone mineral density tests are available, but the most prevalent and recommended is dual-energy X-ray absorptiometry. DXA X-rays can detect small bone loss percentages. The T-score on the bone density evaluation shows how much bone mass differs from a healthy 20-something. The T-score, measured in standard deviations (SD), indicates whether the bone mass is normal, osteopenia, or osteoporosis. This work examines the genetic variation and function of ZBTB40 rs6426794 G/C, rs 7524102 A/G, and rs 34920465 A/G in osteoporosis etiology using molecular methods. The Baghdad Teaching Hospital Bone Density Unit conducts this investigation from September 2020 to January 2021. The DXA test detected osteoporosis in women. Nested PCR was used to investigate the ZBTB40 rs6426794 G/C polymorphism, and biochemic al methods were used to measure vitamin D3 and PTH levels in serum. Calcium concentration was assessed by digestion.

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Risk Management of Osteoporosis in Postmenopausal Women; A Study of Women In a Teaching Hospital

Cited by 5 publications

References 46 publications

Effect of melatonin on the peripheral T lymphocyte cell cycle and levels of reactive oxygen species in patients with premature ovarian failure

Effect of melatonin on the peripheral T lymphocyte cell cycle and levels of reactive oxygen species in patients with premature ovarian failure

Prevalence of osteoporosis in hysterectomised as compared to non-hysterectomized women in 7th decade of life

The study evaluated the ZBTB40 gene polymorphism and biochemical parameters in women suffering from osteoporosis

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