Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis

Moreno-Sepúlveda, José; Checa, Miguel Ángel

doi:10.1007/s10815-019-01552-4

Cited by 45 publications

(37 citation statements)

References 78 publications

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“…The results of the present study encourage the use of NC-FET cycles, whereas AC-FET cycles ought to be used only when ovulation fails. The high rates of HDP show similarities with oocyte donation pregnancies, a known high-risk population for these and other maternal adverse outcomes in ART (Giannakou et al, 2018;Moreno-Sepulveda et al, 2019).…”

Section: Clinical Considerationsmentioning

confidence: 91%

Lower risk of adverse perinatal outcomes in natural versus artificial frozen–thawed embryo transfer cycles: a systematic review and meta-analysis

Moreno-Sepúlveda

Espinós

Checa

2021

Reproductive BioMedicine Online

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Section: Clinical Considerationsmentioning

confidence: 91%

Lower risk of adverse perinatal outcomes in natural versus artificial frozen–thawed embryo transfer cycles: a systematic review and meta-analysis

Moreno-Sepúlveda

Espinós

Checa

2021

Reproductive BioMedicine Online

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“…Yet, also in young women, aged <35 years, the use of donated oocytes compared with autologous oocytes was associated with a higher rate of preterm birth and low birth weight (47). In the SR by Moreno-Sepulveda et al, there was no difference in the rate of preterm birth and low birth weight when adjusted for pre-eclampsia (46). The fact that the foetus is allogenic to the mother's immunological mechanisms may explain the higher risk of pre-eclampsia in OD pregnancies.…”

Section: Oocyte Donation (Od)mentioning

confidence: 92%

“…The number of OD treatments has increased during recent years, and a total of 17,259 deliveries after OD was reported in 2014 from ESHRE ( 2 ), which considerably exceeds the number of deliveries reported in 2013 (+45.5%); 65% of the recipients were 40 years or older. In a recent SR including 23 studies, rates of hypertensive disorders in pregnancy (including pregnancy-induced hypertension, pre-eclampsia, severe pre-eclampsia), preterm birth, very preterm birth, low birth weight, and very low birthweight were increased after OD compared with IVF/ICSI with autologous oocytes (pooled odds ratio 2.64, 1.57, 1.80, 1.25, and 1.37, respectively) ( 46 ). The high occurrence of obstetric complications after OD has been associated with advanced maternal age.…”

Section: Perinatal Outcomementioning

confidence: 99%

Perinatal outcome in children born after assisted reproductive technologies

Wennerholm

Bergh

2020

Upsala Journal of Medical Sciences

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Over the past 40 years access and effectiveness of assisted reproductive technologies (ART) have increased, and to date more than 8 million children have been conceived after ART globally. Most pregnancies resulting from ART are uncomplicated and result in the birth of healthy children. Yet, it is well known that pregnancies following ART are more likely to be affected by obstetric complications such as hypertensive disorders in pregnancy, preterm birth, and low birth weight compared with spontaneously conceived pregnancies. ART children are also at increased risk of birth defects. The majority of the problems arise as a result of multiple pregnancies and can be reduced by transferring a single embryo, thereby avoiding multiple pregnancies. New ART technologies are constantly introduced, and monitoring of the health of ART children is crucial.

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“…Although only few studies are available in literature, equivalent obstetrical outcomes have been reported between the use of vitrified and fresh oocytes ( Cobo et al , 2014 ). However, contrary to the study of Cobo et al (2014) , our study included exclusively pregnancies after heterologous oocytes, which might add to the discordant findings, since an adverse obstetric outcome has been repeatedly reported in donor oocyte pregnancies ( Klatsky et al , 2010 ; Stoop et al , 2012 ; Blazquez et al , 2016 ; Storgaard et al , 2017 ; Moreno-Sepulveda and Checa 2019 ). In addition, the fact that 15% of the mothers in the vitrification group (versus 7% in the fresh group) were from non-Hispanic black origin might also have contributed to the finding of a higher rate of pregnancy-induced hypertensive disorders, which have been reported to be linked to black ethnicity ( Grobman et al , 2018 ).…”

Section: Discussionmentioning

confidence: 86%

Health of 2-year-old children born after vitrified oocyte donation in comparison with peers born after fresh oocyte donation

Marjan

Blockeel

Bonduelle

et al. 2021

Human Reproduction Open

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STUDY QUESTION Does oocyte vitrification adversely affect the health of 2-year-old children compared with peers born after use of fresh oocytes in a donation programme? SUMMARY ANSWER The growth and health of 2-year-old children born after oocyte vitrification are similar to those of peers born after use of fresh oocytes. WHAT IS KNOWN ALREADY Although oocyte vitrification is a well-established procedure in ART, the evidence on its safety for offspring is limited. Currently, no disadvantageous effects of oocyte vitrification have been shown in terms of obstetric and neonatal outcome. However, no data beyond the neonatal period are available to date. STUDY DESIGN, SIZE, DURATION A combined retrospective and prospective observational study was performed in a tertiary reproductive centre. The retrospective data were available in our extensive database of children born after ART. Donor cycles with an oocyte retrieval between January 2010 and March 2017 and a fresh embryo transfer resulting in the livebirth of a singleton were selected from the established oocyte donation programme. Fresh or vitrified oocytes were used in the donor cycles and all pregnancies in oocyte recipients were achieved after ICSI. Only children residing in Belgium were eligible for follow-up. PARTICIPANTS/MATERIALS, SETTING, METHODS Biometric and health parameters of 72 children born after oocyte vitrification were compared with those of 41 children born after use of a fresh oocyte. Data were collected by means of questionnaires and physical examinations at the age of 21–30 months. The primary outcome measures were anthropometry and health at 2 years of age. MAIN RESULTS AND THE ROLE OF CHANCE Length, weight, BMI, head circumference, left arm circumference and waist circumference at the age of 2 years were comparable between the vitrification and fresh group, also after adjustment for treatment, and maternal and neonatal characteristics (all P > 0.05). Health of the children in terms of hospital admission and surgical intervention rates were comparable between the vitrification and fresh group (both P > 0.05). LIMITATIONS, REASONS FOR CAUTION Although the current study is the largest series describing health parameters beyond the neonatal period, the small numbers still preclude definite conclusions. WIDER IMPLICATIONS OF THE FINDINGS This study provides the first evidence indicating that oocyte vitrification does not adversely affect the growth and health of offspring beyond the neonatal period. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by Methusalem grants and by grants from Wetenschappelijk Fonds Willy Gepts, all issued by the Vrije Universiteit Brussel. All co-authors declared no conflict of interest in relation to this work. Both the Centre for Reproductive Medicine and the Centre for Medical Genetics from the UZ Brussel have received several educational grants from IBSA, Ferring, MSD and Merck for either research on oocyte vitrification or for establishing the database for follow-up research and organizing the data collection.

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Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis

Cited by 45 publications

References 78 publications

Lower risk of adverse perinatal outcomes in natural versus artificial frozen–thawed embryo transfer cycles: a systematic review and meta-analysis

Lower risk of adverse perinatal outcomes in natural versus artificial frozen–thawed embryo transfer cycles: a systematic review and meta-analysis

Perinatal outcome in children born after assisted reproductive technologies

Health of 2-year-old children born after vitrified oocyte donation in comparison with peers born after fresh oocyte donation

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