Risk of breast cancer recurrence in patients receiving manual lymphatic drainage: a hospital-based cohort study

Abstract

BackgroundThis retrospective cohort study evaluated whether manual lymphatic drainage (MLD) therapy increases the risk of recurrence of breast cancer.MethodsWe analyzed 1,106 women who were diagnosed with stage 0–3 breast cancer between 2007 and 2011 and experienced remission after surgery and adjuvant therapy. The patients were divided into two groups: group A (n=996), in which patients did not participate in any MLD therapy, regardless of whether they developed breast cancer-related lymphedema (BCRL) after cancer treatment; and group B (n=110), in which patients participated in MLD therapy for BCRL. All patients were monitored until October 2013 to determine whether breast cancer recurrence developed, including local or regional recurrence and distant metastasis. Patients who developed cancer recurrence prior to MLD therapy were excluded from analysis. Risk factors associated with cancer recurrence were evaluated using Cox proportional hazards models.ResultsDuring the monitoring period, 166 patients (15.0%) developed cancer recurrence, including 154 (15.5%) in group A and 12 (10.9%) in group B. The median period from surgery to cancer recurrence was 1.85 (interquartile range 1.18–2.93) years. Independent risk factors for cancer recurrence were tumor histological grading of grade 3, high number (≥3) of axillary lymph node invasion, and a large tumor size (>5 cm). Factors protecting against recurrence were positive progesterone receptor status and receiving radiation therapy. Receiving MLD therapy was not an outcome factor in multivariate analyses (hazard ratio 0.71, 95% confidence interval 0.39–1.29, P=0.259).ConclusionMLD is a gentle procedure that does not increase the risk of breast cancer recurrence in patients who develop BCRL.

Age‐related changes in male forearm skin‐to‐fat tissue dielectric constant at 300 MHz

“…Ageing brings on an increased likelihood of prostate and breast cancer (Fentiman et al ., ; Ottini et al ., ; Bermejo et al ., ). Conditions that treatments for both conditions can include surgery and radiation (Lyman et al ., ; Fentiman et al ., ) and can lead to treatment‐related lymphoedema (Oremus et al ., ; Hsiao et al ., ). Causes of upper extremity oedema and lymphoedema in addition to breast cancer include melanoma surgery and axillary venous thrombosis.…”

Abordagem Fisioterapêutica de uma Paciente com Linfedema de Membro Superior Prévio à cirurgia para Câncer de Mama: Relato de caso

“…Retornou para consulta na fisioterapia em março, abril e outubro de 2016, apresentando amplitude de movimento funcional do membro superior esquerdo (140º para flexão e 150º para abdução), sem dor, linfedema controlado (grau II) 5 , em uso contínuo da braçadeira compressiva, seguindo cuidados preventivos e exercícios domiciliares.…”

“…Estes estudos abordam somente a drenagem linfática manual. Hsiao et al 5 avaliaram o risco de disseminação do câncer de mama em pacientes com linfedema que foram submetidas à drenagem linfática manual, demonstrando que a técnica é segura e não aumenta o risco de disseminação da doença.…”

Daganatos betegekben kialakult másodlagos nyiroködéma ellátása

“…Ha az onkológiai kezelés palliatív célból történik, palliatív ödé-mamentesítésről beszélünk, amely szükség esetén kiegé-szítendő palliatív sebkezeléssel és fájdalomcsillapítással. Számos szerző érvel amellett, hogy a manuális drenálás végzése nem kontraindikált áttétes tumor fennállása esetén, de ilyen esetben a manuális drenálást az adott helyzethez kell adaptálni [15][16][17][18][19]. Elméletileg ugyan a nyirokkollektorokban már jelen lévő tumorthrombusokat befolyásolhatja a manuális drenálás vagy a kompresszió, de a nemzetközi konszenzus is elismerte a KÖK alkalmazásának palliatív előnyeit aktív tumor fennállásakor [11].…”