Risk of developing <scp>P</scp>arkinson's disease among patients with asthma: a nationwide longitudinal study

Cheng, Chih-Ming; Wu, Yihui; Tsai, Shih‐Jen; Bai, Ya‐Mei; Hsu, Ju-Wei; Huang, Kai‐Lin; Su, Tung‐Ping; Li, Cheng Ta; Tsai, Chang‐Youh; Yang, Albert C.; Lin, Wei‐Chen; Pan, Tai‐Long; Chang, Wenhan; Chen, Tzeng Ji; Chen, Mu‐Hong

doi:10.1111/all.12758

Cited by 38 publications

(26 citation statements)

References 31 publications

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“…24 A study using the Taiwan National Health Insurance Research Database found a positive, but not significant, association between PD and allergic rhinitis (hazard ratio = 1.29 [0.97–1.72]). 25 We found that PD was also associated with allergies to plants and antibiotics, but not with allergies to food or animals (Supplementary Data 1). Understanding the biological differences between these different groups of allergies may allow us to hone in on specific immunological pathways that contribute to PD risk.…”

Section: Discussionmentioning

confidence: 84%

The Parkinson’s phenome—traits associated with Parkinson’s disease in a broadly phenotyped cohort

Heilbron

Noyce

Fontanillas

et al. 2019

npj Parkinsons Dis.

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In order to systematically describe the Parkinson’s disease phenome, we performed a series of 832 cross-sectional case-control analyses in a large database. Responses to 832 online survey-based phenotypes including diseases, medications, and environmental exposures were analyzed in 23andMe research participants. For each phenotype, survey respondents were used to construct a cohort of Parkinson’s disease cases and age-matched and sex-matched controls, and an association test was performed using logistic regression. Cohorts included a median of 3899 Parkinson’s disease cases and 49,808 controls, all of European ancestry. Highly correlated phenotypes were removed and the novelty of each significant association was systematically assessed (assigned to one of four categories: known, likely, unclear, or novel). Parkinson’s disease diagnosis was associated with 122 phenotypes. We replicated 27 known associations and found 23 associations with a strong a priori link to a known association. We discovered 42 associations that have not previously been reported. Migraine, obsessive-compulsive disorder, and seasonal allergies were associated with Parkinson’s disease and tend to occur decades before the typical age of diagnosis for Parkinson’s disease. The phenotypes that currently comprise the Parkinson’s disease phenome have mostly been explored in relatively small purpose-built studies. Using a single large dataset, we have successfully reproduced many of these established associations and have extended the Parkinson’s disease phenome by discovering novel associations. Our work paves the way for studies of these associated phenotypes that explore shared molecular mechanisms with Parkinson’s disease, infer causal relationships, and improve our ability to identify individuals at high-risk of Parkinson’s disease.

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Section: Discussionmentioning

confidence: 84%

The Parkinson’s phenome—traits associated with Parkinson’s disease in a broadly phenotyped cohort

Heilbron

Noyce

Fontanillas

et al. 2019

npj Parkinsons Dis.

View full text Add to dashboard Cite

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“…This study uncovered that the β2AR agonist salbutamol, a drug commonly prescribed to treat asthma, was associated with a reduced risk of developing PD in a Norwegian population. Although a connection between allergic diseases and PD is rare, a cross-sectional retrospective study revealed that patients with asthma had an increased risk of PD in a Taiwanese population (Cheng et al, 2015 ). The relationship between asthma and PD remains unknown.…”

Section: Personalized Medicine In Parkinson’s Diseasementioning

confidence: 99%

Biological and Clinical Implications of Comorbidities in Parkinson’s Disease

Santiago

Bottero

Potashkin

2017

Front. Aging Neurosci.

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A wide spectrum of comorbidities has been associated with Parkinson’s disease (PD), a progressive neurodegenerative disease that affects more than seven million people worldwide. Emerging evidence indicates that chronic diseases including diabetes, depression, anemia and cancer may be implicated in the pathogenesis and progression of PD. Recent epidemiological studies suggest that some of these comorbidities may increase the risk of PD and precede the onset of motor symptoms. Further, drugs to treat diabetes and cancer have elicited neuroprotective effects in PD models. Nonetheless, the mechanisms underlying the occurrence of these comorbidities remain elusive. Herein, we discuss the biological and clinical implications of comorbidities in the pathogenesis, progression, and clinical management, with an emphasis on personalized medicine applications for PD.

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“…To ensure diagnostic validity and patient homogeneity, we collected only patients diagnosed by otolaryngologists and neurologists, with at least two consistent tinnitus diagnoses to improve diagnostic validity. Similar methods for the identification of AD and PD had been applied in previous studies 24,25 . In Taiwan, PD is usually diagnosed by neurologists and two of the four main symptoms (shaking or tremor; slowness of movement, called bradykinesia; stiffness or rigidity of the arms, legs or trunk; trouble with balance and possible falls, also called postural instability) must be present over a period of time to consider a PD diagnosis.…”

Section: Study Populationmentioning

confidence: 99%

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

Chu

Liang

Yeh

et al. 2020

Sci Rep

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Previous studies have shown that central auditory dysfunction without severe peripheral hearing loss was associated with higher incidences of cognitive decline and Alzheimer's dementia 11,12. Both hearing loss and central auditory dysfunction are associated with higher risk of developing dementia 5-10 years later 13. Uhlmann et al. 14 demonstrated an association of hearing impairment and Alzheimer's dementia. There may be a pathophysiological interplay of hearing impairment and neurodegeneration. Although the prevalence of tinnitus is not exactly related to the prevalence of hearing loss, chronic tinnitus is usually accompanied by a hearing impairment 4. Previous research revealed that chronic tinnitus was related to the anatomical brain abnormalities, including cortical grey matter reduction and reduced white matter integrity 15. In previous decades, structural and functional brain research showed the correlation between annoying tinnitus and various forms of cognitive dysfunction, especially executive control of attention and working memory 16. Such studies suggest that changes in hearing, olfaction may antecede the beginning of cognitive impairments and dementia as the strong risk factors of AD dementia 17,18. On the other hand, adequate research shows that specific sensory changes may be early biomarkers for AD 13. Previous studies have not used population-based cohort study to evaluate the relationship between tinnitus and subsequence risk of AD and PD. We applied nationwide data from the National Health Insurance (NHI) system to operate a retrospective population-based cohort study in Taiwan. This reliable data has been used for various studies, including tinnitus and AD/PD 19-21. The hypothesis of this study is that tinnitus might be related with the likelihood of subsequent diagnosis of AD and PD. We aim to determine the possibility of an association between tinnitus and a higher risk of AD and PD development. Methods Data sources. The NHI program, an essential health insurance program instituted in 1995, provided comprehensive medical care coverage to about 99% of the residents in Taiwan, including inpatient, outpatient, emergency, and traditional Chinese medicine services 22. Comprehensive information on medical visits, including diagnostic codes and prescription details according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) are provided by the NHI Research Database (NHIRD). NHIRD is supervised by the National Health Research Institutes, with confidentiality kept in congruence with the directives of the NHI Bureau, Taiwan. Data used in the current study are from the Longitudinal Health Insurance Database 2005 (LHID2005). LHID2005 data were methodically and randomly retracted from the NHIRD, which contains data on one million people. No significant differences in the average insured payroll-related amount, sex distribution, or age distribution between patients in the LHID2005 and those in the original NHIRD were reported by NHRI 23 .

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Risk of developing Parkinson's disease among patients with asthma: a nationwide longitudinal study

Abstract: Patients with asthma had an elevated risk of developing Parkinson's disease later in life, and we observed a dose-dependent relationship between greater asthma severity and a higher risk of subsequent Parkinson's disease.

Cited by 38 publications

References 31 publications

The Parkinson’s phenome—traits associated with Parkinson’s disease in a broadly phenotyped cohort

The Parkinson’s phenome—traits associated with Parkinson’s disease in a broadly phenotyped cohort

Biological and Clinical Implications of Comorbidities in Parkinson’s Disease

Tinnitus and risk of Alzheimer’s and Parkinson’s disease: a retrospective nationwide population-based cohort study

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