Risk of diabetes in <scp>HIV</scp>‐infected patients is associated with cirrhosis but not with chronic <scp>HCV</scp> coinfection in a French nationwide <scp>HIV</scp> cohort

Provoost, Abraham P.; Dramé, Moustapha; Cotte, Laurent; Garraffo, R.; Rey, David; Raffi, François; Poizot‐Martin, Isabelle; Puglièse, Pascal; Bani‐Sadr, Firouzé

doi:10.1111/apt.14812

Cited by 7 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, we found that diabetes onset was independently associated with the liver fibrosis stage. These results are in line with those observed in other HIV cohorts [14,15]. On this point, in a large French multicentre cohort, cirrhotic patients had a 2-fold increased risk of developing diabetes but not patients with CHC [15].…”

Section: Discussionsupporting

confidence: 90%

Impact of diabetes on the risk of serious liver events and liver-related deaths in people living with HIV and hepatitis C co-infection: data from the ICONA Foundation Cohort Study

Leone

Lorenzini

Cozzi‐Lepri

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

To investigate the association between diabetes and HCV infection in persons living with HIV and to determine the impact of diabetes on the occurrence of serious liver events (SLE) and liver-related deaths (LRD) among HIV/HCV co-infected patients. Patients were included if they had at least one follow up visit. In a cross-sectional analysis among all HIV patients, we have investigated the association between diabetes and HCV infection. A further longitudinal analysis was performed in the population of HIV/HCV co-infected free from SLE with FIB-4 index <3.25 at baseline, using the following endpoints: A) first event between SLE and LRD; B) liver fibrosis progression defined as the first of two consecutive FIB-4>3.25; C) first event between SLE, LRD and liver fibrosis progression. Data from 15,571 HIV patients were analysed: 2,944 (18.9%) were HCV-Ab positive and 739 (4.7%) presented a diagnosis of diabetes at their last follow-up. Among HIV/HCV co-infected population, 107 patients had a diagnosis of diabetes. Viremic HCV co-infected patients had 3-fold risk of diabetes onset than HCV uninfected patients. On HIV/HCV co-infected population, 85 SLEs/LRDs occurred over 20,410 PYFU, for an IR of 4.2/1000 PYFU (95%CI 3.4-5.2). Diabetic patients had 3-fold risk of pooled SLE and LRD than patients without diabetes. Furthermore, viremic HCV infection was independently associated with higher risk of SLE/LRD (aIRR 3.35 [95%CI 1.14-9.83]). In HIV-infected patients, viremic HCV co-infection is a strong predictor of diabetes. Among HIV/HCV co-infected population, diabetic patients showed an increased risk of SLE/LRD compared with those without diabetes.

show abstract

Section: Discussionsupporting

confidence: 90%

Impact of diabetes on the risk of serious liver events and liver-related deaths in people living with HIV and hepatitis C co-infection: data from the ICONA Foundation Cohort Study

Leone

Lorenzini

Cozzi‐Lepri

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

show abstract

“…As both can fluctuate over time with and without cART, our focus was on the last 24 months of follow-up when most PLWH were under effective treatment. The occasional viremia (viral blips), defined by plasma VL ≥200 RNA copies/ ml, is well expected, and at least one other longitudinal study (a French HIV-1 cohort) has reported that detectable VL is associated with a modest risk for incident T2DM when compared to non-detectable VL (35). In the new era that calls for prompt HIV-1 diagnosis and linkage to care (the 90:90:90 initiative) (36), at least 27% of PLWH will continue to be viremic and thus at high risk for T2DM.…”

Section: Discussionmentioning

confidence: 93%

Rates and Correlates of Incident Type 2 Diabetes Mellitus Among Persons Living With HIV-1 Infection

Shrestha

Burkholder

et al. 2020

Front. Endocrinol.

View full text Add to dashboard Cite

The prevalence of various comorbidities continue to rise in aging persons living with HIV-1 infection (PLWH), and our study here aimed to assess the rates and correlates of incident type 2 diabetes mellitus (T2DM) in PLWH from a retrospective, southeastern U.S. cohort. Based on electronic health records, we examined patient demographics, body mass index (BMI), HIV-1-related outcomes, hepatitis C virus co-infection, common comorbidities (e.g. shingles and asthma), usage of protease inhibitors, and usage of statins as potential correlates for T2DM occurrence. Among 3,975 PLWH with ≥12 months of follow-up between January 1999 and March 2018, the overall rate of incident T2DM was 135 per 10,000 person-years, almost 2-fold higher than the rate reported for the general U.S. population. In multivariable models (354 T2DM patients and 3,617 control subjects), sex, BMI, nadir CD4+ T-cell count, HIV-1 viral load (VL) and duration of statin use were independent correlates of incident T2DM (adjusted P <0.05 for all), with clear consistency in several sensitivity analyses. The strongest associations (adjusted odds ratio/OR >2.0 and P <0.0001) were noted for: i) statin use for ≥6 months (OR = 10.2), ii) BMI ≥30 kg/m2 (OR = 3.4), and iii) plasma VL ≥200 copies/ml (OR = 2.2). Their collective predictive value was substantial: the C-statistic for area under the receiver operating characteristics curve was 0.87 (95% CI = 0.84-0.91), showing close similarity between two major racial groups (C-statistic = 0.87 for African Americans and 0.91 for European Americans). Overall, these findings not only establish a promising algorithm for predicting incident T2DM in PLWH but also suggest that patients who are obese and use statins should require special consideration for T2DM diagnosis and prevention.

show abstract

“…In their recent editorial regarding our paper, Drs Höner zu Siederdissen and Mederacke state that “it is well established that hepatitis C virus (HCV) monoinfected patients have a higher frequency of diabetes mellitus (DM), which may be caused by direct viral effects as well as lifestyle characteristics. In human immunodeficiency virus (HIV)/HCV coinfected patients mixed results have been observed regarding the association with DM.”…”

mentioning

confidence: 94%

“…In conclusion, our results are not only in keeping with some other studies performed among HIV/HCV‐co‐infected patients, but they are also in line with findings in HCV‐mono‐infected patients . In addition, we underline that the major strength of our study was to evaluate, in the same analysis and—to the best of our knowledge—for the first time, not only HCV serology status or chronic HCV infection, but also major HCV covariates, in particular the duration of HCV infection and cirrhosis, which is a major confounding factor for DM.…”

mentioning

confidence: 99%

Editorial: diabetes in HIV‐infected patients—do not blame the usual suspect! Authors’ reply

Provoost¹,

Dramé²,

Bani‐Sadr

2018

Aliment Pharmacol Ther

Self Cite

View full text Add to dashboard Cite

show abstract

Risk of diabetes in HIV‐infected patients is associated with cirrhosis but not with chronic HCV coinfection in a French nationwide HIV cohort

Abstract: Our study shows that in the HIV population, cirrhosis is associated with an increased occurrence of DM, but not chronic HCV infection or duration of HCV infection.

Cited by 7 publications

References 49 publications

Impact of diabetes on the risk of serious liver events and liver-related deaths in people living with HIV and hepatitis C co-infection: data from the ICONA Foundation Cohort Study

Impact of diabetes on the risk of serious liver events and liver-related deaths in people living with HIV and hepatitis C co-infection: data from the ICONA Foundation Cohort Study

Rates and Correlates of Incident Type 2 Diabetes Mellitus Among Persons Living With HIV-1 Infection

Editorial: diabetes in HIV‐infected patients—do not blame the usual suspect! Authors’ reply

Contact Info

Product

Resources

About