Risk of empyema in patients with chronic liver disease and cirrhosis: A nationwide, population‐based cohort study

Shen, Te Chun; Chen, Chia-Hung; Lai, Hsueh Chou; Lin, Cheng Li; Tu, Chih Yen; Hsia, Te Chun; Shih, Chuen Ming; Hsu, Wu Huei; Sung, Fung Chang

doi:10.1111/liv.13330

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…Recently, an increasing number of empyema cases in RA have been identified; therefore, the association between RA and pleural empyema has been recognized [3,4]. In this study, the incidence of pleural empyema was 23.6/10,000 in RA, which was similar to certain immunocompromised conditions with preexisting pleural effusion (18.2/10,000 in cirrhosis and 23.7/10,000 in end-stage renal disease) [25,26].…”

Section: Discussionsupporting

confidence: 55%

Rheumatoid arthritis increases the risk of pleural empyema

2020

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BackgroundRheumatoid arthritis (RA) can lead to various pulmonary manifestations. Evidence shows the possible association between RA and pleural empyema.MethodsWe conducted a retrospective cohort study to investigate the risk of pleural empyema in patients with RA. The RA group (n = 29,061) included newly diagnosed adult patients between 2000 and 2012. The comparison group (n = 1,16,244) included individuals without RA at a 1:4 ratio of frequency matched by age, gender, and diagnosis year. The occurrence of pleural empyema was monitored until the end of 2013.ResultsPatients with RA had a higher risk of developing pleural empyema than those without RA (23.6 vs 1.82 per 10,000 person-years, adjusted hazard ratio = 11.0, 95% confidence interval [CI] = 8.90–13.5). Furthermore, intensive care unit admission rates of pleural empyema were 37.7% in the RA group and 37.2% in the comparison group (adjusted odds ratio [OR] = 1.02, 95% CI = 0.66−1.57). The 30-day mortality rates of pleural empyema were 11.2% in the RA group and 10.9% in the comparison group (adjusted OR = 1.01, 95% CI = 0.51−1.88).ConclusionPatients with RA are at a greater risk of developing pleural empyema than those without RA.

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Section: Discussionsupporting

confidence: 55%

Rheumatoid arthritis increases the risk of pleural empyema

2020

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“…The data of one million people randomly selected from the medical claims records of the NHI 2000 Registry of Beneficiary enrollees were analyzed. The LHID2000 has been successfully used innumerous studies [ 31 , 32 ].…”

Section: Methodsmentioning

confidence: 99%

Cancer risk in patients with candidiasis: a nationwide population-based cohort study

et al. 2017

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BackgroundCandidiasis and certain types of cancer are related to immunocompromised status. This study aimed to evaluate whether Candida infection (CI) is associated with subsequent cancer risk in Taiwan.MethodsData from the National Health Insurance system of Taiwan were used to evaluate the association between CI and cancer risk. The CI cohort comprised 34,829 patients. Each patient was randomly frequency matched with one person from the general population without CI on the basis of age, sex, year of index date of CI diagnosis, and other characteristics to generate the control group. We used Cox's proportional hazard regression analysis to estimate the effects of CI on subsequent cancer risk.ResultsCompared with the control group, patients with CI had a significantly higher risk of overall cancer (adjusted hazard ratio = 1.19, 95% confidence interval = 1.09–1.30). For subsite analysis, the risks of hematologic malignancy and head and neck, pancreatic, skin, and thyroid cancers were significantly higher in the CI group. Stratified analyses by sex, age, and follow-up time revealed different patterns.ConclusionOur study suggested that CI can significantly increase overall and some individual cancer risks, which is partially compatible with previous findings.

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“…It has been reported that diabetic patients conferred a 1.71-fold increased risk of empyema thoracis without any comorbidity [21]. A series of retrospective studies showed that the hazard of developing empyema was higher for patient with diabetes mellitus than those with chronic obstructive lung disease or chronic liver disease and cirrhosis [20,22]. Gosiewski T et al found the quantity of candida in the feces of patients with diabetes was signi cantly higher compared to non-diabetic controls [23].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and related factors of fungal empyema thoracis

Zhong¹,

Qian²,

Hou³

et al. 2020

Preprint

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ObjectData on the characteristics and related factors of fungal empyema thoracis (FET) are limited. Our aim is to investigate the clinical characteristics and related factors of FET.MethodsWe conducted a retrospective study of patients with positive culture from pleural effusion who were admitted to the First Affiliated Hospital of Soochow University between January 2007 and January 2018. The clinical and laboratory characteristics of all study participants were collected. Logistic regression models were used to assess the related factors of FET.ResultsThere were 30 patients diagnosed with FET. The median age of patients with FET was 62.7 years old and 24 (80.0%) were male. The most frequent pathogens of FET were Candida albicans (55.9%). Diabetes mellitus (23.3% vs. 7.9%, P = 0.019) and upper gastrointestinal tract perforation or rupture (20.0% vs. 2.1%, P < 0.001) were associated with increased risk of FET. The adjusted odds ratios (95% confident interval) were 3.11 (1.02–9.56) for diabetes mellitus and 12.71 (3.47–46.55) for upper gastrointestinal tract perforation or rupture. There were 10 deaths (33.3%) among FET patients after one-year of follow-up.ConclusionsDiabetes mellitus and upper gastrointestinal tract perforation or rupture were associated with increased risk of FET.

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Risk of empyema in patients with chronic liver disease and cirrhosis: A nationwide, population‐based cohort study

Abstract: The present study shows that CLDC patients have an increased risk of empyema. These patients need timely monitor for the risk of empyema, particularly for those with comorbid cirrhosis, alcoholic disorder, gastrointestinal haemorrhage and ascites.

Cited by 11 publications

References 27 publications

Rheumatoid arthritis increases the risk of pleural empyema

Rheumatoid arthritis increases the risk of pleural empyema

Cancer risk in patients with candidiasis: a nationwide population-based cohort study

Clinical characteristics and related factors of fungal empyema thoracis

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