Risk of epithelial ovarian cancer among women with benign ovarian tumors: a follow-up study

Guleria, Sonia; Jensen, Allan; Toender, Anita; Kjær, Susanne K.

doi:10.1007/s10552-019-01245-4

Cited by 16 publications

(16 citation statements)

References 30 publications

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“…25 Guleria et al have suggested that older patients presenting with benign cystadenomas are at higher risk of developing malignancy. 31 Most benign tumours in our study showed unilateral involvement. This suggests that older patients who underwent unilateral cystectomy should be monitored closely for the possibility of malignancy in the other ovary.…”

Section: Benign Epithelial Ovarian Neoplasmsmentioning

confidence: 50%

“…These findings support the molecular pathogenesis and stepwise progression from benign mucinous cystadenoma to borderline mucinous tumour, and finally to invasive MC. 21,31 All four MCs were bilateral and greater than 13 cm. According to a diagnostic algorithm by Yemelyanova et al for differentiating primary mucinous ovarian tumours from metastatic tumours, a unilateral mucinous tumour greater than 13 cm in size greatly favours a tumour of primary ovarian origin.…”

Section: Twomentioning

confidence: 99%

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A retrospective study of the epidemiology and histological subtypes of ovarian epithelial neoplasms at Charlotte Maxeke Johannesburg Academic Hospital

Pillay

Wadee

2021

Southern African Journal of Gynaecological Oncology

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Background: Epithelial ovarian neoplasms constitute the majority of ovarian tumours and are the most common malignant ovarian neoplasm. They are the eighth leading cause of cancer deaths worldwide. This study evaluated the epidemiology and histological subtypes of epithelial ovarian neoplasms at a single institution. Methods: This retrospective, quantitative analysis evaluated 123 epithelial ovarian neoplasms between 2013 and 2017 and classified them according to age, biological behaviour and histological subtype. Results: Of 123 cases, 64 (52.0%), tumours were benign, 30 (24.4%) were borderline and 29 (23.6%) tumours were malignant. Serous cystadenoma was the most common benign tumour (42.2%). Mucinous borderline tumours were the most common borderline neoplasm (50.0%). High-grade serous carcinoma was the most common carcinoma (58.6%). Patients presented at an older age with borderline tumours and malignant tumours, compared with patients with benign tumours. Conclusion:The current study demonstrated that serous tumours were the most common type of benign and malignant tumours whilst mucinous neoplasms were the commonest subtype of borderline tumours. These findings are congruent with multiple similar studies. A higher number of borderline tumours were seen in this cohort in comparison with previous studies. This suggests a need for additional sampling of borderline tumours, over and above the international standard, in our population, to definitively exclude invasive malignancy. This study also demonstrated the histological progression of benign serous and mucinous tumours to borderline tumours and low-grade serous carcinoma and mucinous carcinoma, respectively, which supports the stepwise tumour progression model of these tumours.

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Section: Benign Epithelial Ovarian Neoplasmsmentioning

confidence: 50%

Section: Twomentioning

confidence: 99%

A retrospective study of the epidemiology and histological subtypes of ovarian epithelial neoplasms at Charlotte Maxeke Johannesburg Academic Hospital

Pillay

Wadee

2021

Southern African Journal of Gynaecological Oncology

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“…The risk was independent of the age and was accelerated up to 20 years after diagnosing benign ovarian tumours. No link was found between other histological types of EOC and previous benign ovarian tumours [ 19 ].…”

Section: What Is New About Epithelial Ovarian Cancer?mentioning

confidence: 99%

What is new about ovarian malignancies?

Grabska¹,

Pilarska²,

Fudalej³

et al. 2021

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Ovarian cancer is one of the most prevalent pathologies in gynaecology. This malignancy can be divided into 2 large groups: epithelial and non-epithelial. Because epithelial ovarian cancers (EOC) are the most commonly diagnosed, this paper focuses on the latest therapies associated with this disease. Due to the difficult diagnosis, EOC is frequently detected in the advanced stage. The treatment is usually complex and requires specialist knowledge. Advances and new ideas, such as identification of various genes and molecules that can serve as prognostic factors, might increase patients' chances of survival; they may contribute to optimization of patients' treatment, deciding whether to use aggressive treatment strategies, and predicting chemoresistance. Moreover, new strategies might also improve the quality of life of patients. The study aimed to analyse and discuss the latest reports on new methods of managing EOC.

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“…7 Benign ovarian tumors may be associated with an increased long-term risk of mucinous ovarian cancer. 8 In contrast, some authors report that malignant transformation of an ovarian cyst is very rare and that women with ovarian cysts of benign appearance have no increased risk of cancer. 5 Although pelvic ultrasound is the first-line examination in the diagnosis of ovarian tumors, it does not differentiate benign malignancy with 100% reliability.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and management of benign ovarian tumors at the Ignace Deen Maternity Hospital of Conakry University Hospital in Guinea

Diallo

Bah

Magassouba

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Benign ovarian tumors are a common reason for consultation and intervention in gynecology. The objective of this was to describe the clinical, ultrasonographic, histological and therapeutic aspects of benign ovarian tumors in the department.Methods: This is a retrospective and descriptive study of three years and six months from January 1, 2016, to June 30, 2019, which focused on the records of women-operated during this period of benign ovarian tumors.Results: The incidence of benign ovarian tumors was 12.58%. The circumstances of discovery were dominated by disorders of the menstrual cycle (35.05%) followed by infertility (20.78%), the sensation of a pelvic mass (19.48%), and pelvic pain. (15.58%). The ultrasound report was in favor of a serous cyst in 74% of cases, a mucoid cyst in 14% of cases, a 9% dermoid cyst, and a 3% endometriotic cyst. Histology revealed serous cystadenoma in 54% of cases, mucinous cystadenoma in 13% of cases, mature poly tissue teratoma in 7% of cases, and endometrial cyst in 3% of cases. Cystectomy was the most performed surgical procedure (71%).Conclusions: Benign ovarian tumors are common in our practice. The most common histological forms were serous and mucinous cystadenomas. Conservative treatment has been practiced in the majority of cases.

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Risk of epithelial ovarian cancer among women with benign ovarian tumors: a follow-up study

Cited by 16 publications

References 30 publications

A retrospective study of the epidemiology and histological subtypes of ovarian epithelial neoplasms at Charlotte Maxeke Johannesburg Academic Hospital

A retrospective study of the epidemiology and histological subtypes of ovarian epithelial neoplasms at Charlotte Maxeke Johannesburg Academic Hospital

What is new about ovarian malignancies?

Diagnosis and management of benign ovarian tumors at the Ignace Deen Maternity Hospital of Conakry University Hospital in Guinea

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