Risk of Familial Breast Cancer

Anderson, D. E.; Badzioch, Michael D.

doi:10.1016/s0140-6736(84)90438-0

Cited by 10 publications

(8 citation statements)

References 1 publication

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“…The cumulative probability that a 30-year-old woman with a mother or sister with breast cancer will develop breast cancer by the age of 70 years is reported to be between seven and 18 percent. [14][15][16] While this risk increases as the number of relatives with breast cancer increases, the probability of cancer development if both a mother and sister have bilateral breast cancer has been reported to be only 25 percent. 16 The cumulative risk of breast cancer development in women with a family history of breast cancer rarely exceeds 30 percent, making it critically important to distinguish those women with a hereditary breast cancer from those with a family history of the disease.…”

Section: Risk Factorsmentioning

confidence: 99%

The woman at increased risk for breast cancer: evaluation and management strategies

Bilimoria

Morrow

1995

CA: A Cancer Journal for Clinicians

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Section: Risk Factorsmentioning

confidence: 99%

The woman at increased risk for breast cancer: evaluation and management strategies

Bilimoria

Morrow

1995

CA: A Cancer Journal for Clinicians

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“…The first step in preventing breast cancer is identifying the risk factors. The most important risk factors are 1-aging [2], 2-reproduction-related factors such as early menarche, late menopause, nuliparity, and advanced maternal age [3], 3-benign lesions of breast [4], 4-lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) [5], 5-previous history of breast cancer [6], 6-positive family history of breast cancer [7], and 7-environmental factors such as radiation, hormone replacement therapy (HRT) and oral contraceptives [8,9]. Using statistical models, the risk of breast cancer is quantitatively calculated based on analyzing all the risk factors.…”

Section: Introductionmentioning

confidence: 99%

The Applicability of the Gail Model in Iranian Population

Farahmand

Shojamoradi

Najafi

et al. 2017

mcij

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Introduction: Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population was evaluated. Methods: This was a case-control study. The case group was formed of the referrals to Breast Cancer Research Center, Academic Center for Education Culture and Research (ACECR), who were affected by different types of aggressive cancer. Results: A total of 416 patients with breast cancer and the same number in the control group were considered during the study. There were no meaningful statistical differences in age at menarche, age at first live birth, and nulliparous women between case and control groups. The average of five-year risk of breast cancer in the case and control groups had no statistically significant difference. Chemoprevention was only eligible for 7.2% of the patients based on 1.67% five-year risk. In addition, there was no statistically meaningful difference between comparative risk and breast cancer risk in a lifetime. Conclusions: The low risks estimated by the Gail model among patients with breast cancer as well as the absence of meaningful statistical difference in the estimated risks by this model between the case and control groups showed that the Gail model had insufficient efficiency in determining breast cancer risk in the Iranian society.

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“…One of the strongest and most consistently found risk factors for breast cancer is a family history of the disease. Previous studies have compared breast cancer patients with a family history with those without, and found that the familial cases frequently have an early age at onset and often suffer from bilateral disease (Anderson, 1971(Anderson, , 1974Anderson & Badzioch, 1985).…”

mentioning

confidence: 99%

Cancer experience in the relatives of an unselected series of breast cancer patients

Teare

Wallace²,

Harris³

et al. 1994

Br J Cancer

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Simmary First-and second-degree relatives of an unselected series of 402 breast cancer patients have been studied for their cancer experience. In the first-degree relatives an excess of all cancers is seen [overall relative risk (RR) = 1.28, P = 0002; males RR = 1.26, P = 0.047; females RR = 1.30, P= 0.022). There is a marked excess of sarcoma (RR = 4.26, P = 0.0064); females are at high risk of breast cancer (RR = 2.68, P<0.0001) and males have an excess of carcinoma of the lip, oral cavity and pharynx (RR = 4.22, P =0.0032). Second-degree relatives have a non-significant excess of all cancers (RR = 1. 14, P = 0. 14); females have a borderline excess of breast cancer (RR = 1.53, P = 0.08) and an excess of carcinoma of the kidney (RR = 7.46, P= 0.0012) and males have an excess of carcinoma of the trachea and lung (RR = 1.50, P = 0.032). Ltd., 1994 Br.

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Risk of Familial Breast Cancer

Cited by 10 publications

References 1 publication

The woman at increased risk for breast cancer: evaluation and management strategies

The woman at increased risk for breast cancer: evaluation and management strategies

The Applicability of the Gail Model in Iranian Population

Cancer experience in the relatives of an unselected series of breast cancer patients

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