Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b

Sun, Yuelian; Christensen, Jakob; Hviid, Anders; Li, Jiong; Vedsted, Peter; Olsen, Jørn; Vestergaard, Mogens

doi:10.1001/jama.2012.165

Cited by 84 publications

(54 citation statements)

References 25 publications

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“…31 Other infant vaccines currently in use, for instance the DTaP, inactivated poliovirus, and Haemophilus influenza type B combined vaccine (DTaP-IPV-HIB), have not been associated with seizures in the United States, 32 although DTaP-IPV-HIB has been linked with increased febrile seizures in Denmark. 24 Other early childhood vaccines that have been associated with febrile seizures in the United States include inactivated influenza vaccine, but only in some influenza seasons, such as 2010-2011, and the 13-valent pneumococcal conjugate vaccine. 33 The risk for seizures after inactivated influenza vaccine and 13-valent pneumococcal conjugate vaccine was greatest if the vaccines were given the same day and in the second year of life.…”

Section: Discussionmentioning

confidence: 99%

“…We did not include the first dose of hepatitis B vaccine (recommended shortly after birth) in the analysis. We examined only the first dose of each vaccine because others have observed that the first dose of certain vaccines (diphtheria, tetanus, and acellular pertussis vaccine [DTaP] 24 and measles-containing vaccines 16 ) may be the most reactogenic. We did not analyze specific "catch-up" vaccination schedules.…”

Section: Defining Exposure Status: Immunization On Time Versus Delayedmentioning

confidence: 99%

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Timely Versus Delayed Early Childhood Vaccination and Seizures

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Reasons for childhood immunization delay include parental intent and barriers such as transportation. To date there has been 1 study of the association of delayed vaccination and seizures, which found measlesmumps-rubella and measles-mumps-rubella-varicella vaccines are both associated with a higher rate of seizures if received after 15 months of age.WHAT THIS STUDY ADDS: Our study found no association between the timing of vaccination and occurrence of seizures in the first year of life. By using different methods, our results support the observation that delaying vaccination with measles-containing vaccines past 15 months of age increases the incidence of postvaccination seizures. abstract BACKGROUND: Little is known regarding the timing of childhood vaccination and postvaccination seizures.

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Section: Discussionmentioning

confidence: 99%

Section: Defining Exposure Status: Immunization On Time Versus Delayedmentioning

confidence: 99%

Timely Versus Delayed Early Childhood Vaccination and Seizures

et al. 2014

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“…17 Likewise, Sun et al reported that the risk of febrile seizure may be increased after DTaP immunization, with relative risk of 6.02 on the first day and decreasing to 3.94 on the second day. 18 In conclusion, the DTwP-HB-Hib combined vaccine is immunogenic and safe, as well as comparable to the Hib vaccine given simultaneously with the DTwP-HB vaccine.…”

mentioning

confidence: 79%

The immunogenicity and safety of the new, Indonesian DTwP-HB-Hib vaccine compared to the DTwP/HB vaccine given with the Hib vaccine

Bachtıar

Rusmil

Sudigdoadi

et al. 2017

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“…1 However, development of neurologic deficits or epileptogenesis could not be related to vaccinations, in several independent epidemiologic studies. [2][3][4][5][6] In the general pediatric population, the risk of febrile seizures is twofold to fivefold increased on the day of administration of an inactivated vaccine and from day 5 up to 2 weeks after administration of a live attenuated vaccine. 2,5-9 A seizure within this risk period might be the first of an epilepsy syndrome, and parents might misinterpret the vaccination as the primary cause of the epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Etiologies for Seizures Around the Time of Vaccination

et al. 2014

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OBJECTIVES: This study was an assessment of the incidence, course, and etiology of epilepsy with vaccination-related seizure onset in a population-based cohort of children. METHODS: The medical data of 990 children with seizures after vaccination in the first 2 years of life, reported to the National Institute for Public Health and Environment in the Netherlands in 1997 through 2006, were reviewed. Follow-up data were obtained of children who were subsequently diagnosed with epilepsy and had had seizure onset within 24 hours after administration of an inactivated vaccine or 5 to 12 days after a live attenuated vaccine. RESULTS: Follow-up was available for 23 of 26 children (median age: 10.6 years) with epilepsy onset after vaccination. Twelve children developed epileptic encephalopathy, 8 had benign epilepsy, and 3 had encephalopathy before seizure onset. Underlying causes were identified in 15 children (65%) and included SCN1A–related Dravet syndrome (formerly severe myoclonic epilepsy of infancy) or genetic epilepsy with febrile seizures plus syndrome (n = 8 and n = 1, respectively), a protocadherin 19 mutation, a 1qter microdeletion, neuronal migration disorders (n = 2), and other monogenic familial epilepsy (n = 2). CONCLUSIONS: Our results suggest that in most cases, genetic or structural defects are the underlying cause of epilepsy with onset after vaccination, including both cases with preexistent encephalopathy or benign epilepsy with good outcome. These results have significant added value in counseling of parents of children with vaccination-related first seizures, and they might help to support public faith in vaccination programs.

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Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus, and Haemophilus Influenzae Type b

Abstract: DTaP-IPV-Hib vaccination was associated with an increased risk of febrile seizures on the day of the first 2 vaccinations given at 3 and 5 months, although the absolute risk was small. Vaccination with DTaP-IPV-Hib was not associated with an increased risk of epilepsy.

Cited by 84 publications

References 25 publications

Timely Versus Delayed Early Childhood Vaccination and Seizures

Timely Versus Delayed Early Childhood Vaccination and Seizures

The immunogenicity and safety of the new, Indonesian DTwP-HB-Hib vaccine compared to the DTwP/HB vaccine given with the Hib vaccine

Etiologies for Seizures Around the Time of Vaccination

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