Risk of fractures in celiac disease patients: a cross-sectional, case-control study

Vázquez, Horacio; Mazure, Roberto M.; Gonzalez, Diana; Flores, Daniel; Pedreira, Silvia C.; Niveloni, Sonia I.; Smecuol, Edgardo; Mauriño, Eduardo; Bai, Julio C.

doi:10.1111/j.1572-0241.2000.01682.x

Cited by 198 publications

(93 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One study has reported an increased risk of peripheral fractures in those with celiac disease. However, most fractures were recorded prior to diagnosis or in those noncompliant with their gluten-free diet [14]. Another study challenged this finding by reporting no increased risk of fractures before or after the diagnosis, yet verification of the diagnosis of celiac disease was low (78%) [15].…”

Section: Introductionmentioning

confidence: 99%

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

et al. 2007

View full text Add to dashboard Cite

Celiac disease is associated with decreased bone density, but there are conflicting data regarding fracture risk. We determined the fracture incidence relative to matched controls in a population-based cohort with celiac disease before and after diagnosis. Olmsted County residents with celiac disease (n = 83) diagnosed between 1950 and 2002 were compared with 166 gender and age matched controls. Fracture histories were ascertained from each subject's medical records. Celiac disease is linked to an increased fracture risk before and after diagnosis. Before the index date, cases had a fracture rate twice that of controls (CI: 1.0-3.9, P = 0.045) and 2.5-fold greater after the index date (CI: 1.1-5.6, P = 0.026). Appendicular and axial fractures were 2.5 (CI: 0.9-6.5) and 3.2 times more likely (CI: 1.0-10.5) after the index date. These observations support a rationale for earlier detection of celiac disease, and active management of bone disease before bone effects have occurred, to reduce the persistent risk of fractures.

show abstract

Section: Introductionmentioning

confidence: 99%

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

et al. 2007

View full text Add to dashboard Cite

show abstract

“…A cross-sectional, case control study (25) of 165 Argentinian adults with malabsorption detected fractures in 25% of patients with symptomatic celiac disease but only 8% of those with functional gastrointestinal disorders. Radial and vertebral fractures were most common; three-fourths of the fractures in celiac patients occurred before the age of 50.…”

Section: The Case For Screening-michael Freemarkmentioning

confidence: 99%

Screening for Celiac Disease in Children With Type 1 Diabetes

2003

View full text Add to dashboard Cite

“…Moreover, CD associates with metabolic bone disease. The frequency of low bone mineral density (BMD) among coeliac patients varies widely between different studies due to differences in diagnostic criteria, geographical distribution and patient selection (12)(13)(14). The presence of significant malabsorption leads to a more severe bone loss in CD (15), although BMD is lower in asymptomatic patients compared to healthy subjects, as well (16).…”

Section: K Lorinczy Et Al Rev Esp Enferm Dig (Madrid)mentioning

confidence: 99%

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Lőrinczy

Juhász

Csontos

et al. 2013

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Introduction and objectives: coeliac disease (CD) and its cutaneous manifestation, dermatitis herpetiformis are both (DH) glutensensitive diseases. Metabolic bone disease is common among patients with CD, even in asymptomatic forms. Data are scarce about bone density in patients with dermatitis herpetiformis. The aim of our study was to compare bone mineral density (BMD) of celiac and dermatitis herpetiformis patients.Methods: 34 coeliac patients, 53 with dermatitis herpetiformis and 42 healthy controls were studied. The mean age was 38.0 ± 12.1, 32.18 ± 14.95, 35.33 ± 10.41 years in CD, dermatitis herpetiformis, and healthy controls, respectively. Bone mineral density of the lumbar spine, the left femoral neck and radius were measured by dual-energy X-ray absorptiometry. Low bone density, osteopenia and osteoporosis were defined as a body mass density (BMD) T-score between 0 and -1, between -1 and -2.5, and under -2.5, respectively.Results: at lumbar region, consisting of dominantly trabecular compartment, a decreased BMD was detected in 49 % (n = 26) patients with dermatitis herpetiformis, 62 % (n = 21) of CD patients, and 29 % (n = 12) of healthy controls, respectively. Lower BMD were measured at the lumbar region in dermatitis herpetiformis and CD compared to healthy subjects (0.993 ± 0.136 g/cm 2 and 0.880 ± 0.155 g/cm 2 vs. 1.056 ± 0.126 g/cm 2 ; p < 0.01). Density of bones consisting of dominantly cortical compartment (femoral neck) did not differ in dermatitis herpetiformis and healthy subjects.Conclusions: our results show that a low bone mass is also frequent among patients with dermatitis herpetiformis. Bone mineral content in these patients is significantly lower in those parts of the skeleton which contain more trabecular than cortical bone.

show abstract

Risk of fractures in celiac disease patients: a cross-sectional, case-control study

Cited by 198 publications

References 16 publications

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

Screening for Celiac Disease in Children With Type 1 Diabetes

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Contact Info

Product

Resources

About