Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment

Lu, Yen‐Ting; Hsin, Chung‐Han; Lu, Ying‐Chou; Wu, Meng‐Che; Huang, Jing‐Yang; Huang, Cheng−Chen; Wang, Po-Hui; Yang, Shun‐Fa

doi:10.1038/s41598-021-85598-4

Cited by 6 publications

(5 citation statements)

References 42 publications

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“…Their results showed that peptic ulcer disease was closely related to the increased incidence of laryngeal cancer and hypopharyngeal cancer. Helicobacter pylori treatment may help prevent HNC in patients with peptic ulcer disease (49). Whether bacterial infection increases the occurrence of laryngeal cancer or leads to a poor prognosis remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Is Laryngeal Squamous Cell Carcinoma Related to Helicobacter pylori?

Huang

et al. 2022

Front. Oncol.

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BackgroundLaryngeal carcinoma is a primary malignant tumor originating from the laryngeal mucosa. In recent years, an increasing number of studies have confirmed that Helicobacter pylori may play a role in the occurrence and development of laryngeal cancer. We conducted a systematic review and meta-analysis to identify and emphasize the relationship between laryngeal cancer and Helicobacter pylori infection.MethodsWe actively searched for systematic reviews of PubMed, Embase, Web of Science, and Cochrane libraries to select studies that met the recommended guidelines. A total of 1756 patients with laryngeal cancer were included in this study to assess the association of Helicobacter pylori in the larynx with laryngeal cancer. A subassessment of the risk of bias for each study that met the inclusion criteria was carried out. To illustrate the reasons for heterogeneity, we performed a subgroup analysis to determine the type of study, the quality of the article, the diagnostic method, and the impact of exposure factors.ResultsThe meta-analysis included a total of 17 case-control studies on the association between Helicobacter pylori in the larynx and laryngeal cancer. Our meta-analysis showed that Helicobacter pylori infection in the larynx significantly increased the risk of malignant tumors in the larynx (odds ratio, 2.96; 95% CI, 1.83-4.78; P<0.00001; I2 = 86%). They still existed when we controlled for patients’ exposure to smoking factors (odds ratio, 3.86; 95% CI, 1.89–7.88).ConclusionThis systematic review and meta-analysis showed an association between Helicobacter pylori and laryngeal cancer. These findings are consistent with the understanding that chronic inflammatory tissue insult may lead to the development of malignancy. Controlling risk factors will help us identify patients with an increased risk of laryngeal cancer.

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Section: Discussionmentioning

confidence: 99%

Is Laryngeal Squamous Cell Carcinoma Related to Helicobacter pylori?

Huang

et al. 2022

Front. Oncol.

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“…The definition of PUD was based on either a discharge diagnosis of PUD or a diagnosis of PUD confirmed at least twice in an outpatient department by gastroenterologists with a prescription involving proton pump inhibitors (PPIs). This definition has been used in previous studies 18,19 . To ensure that the PUD was incident during the follow‐up period, we excluded participants with pre‐existing PUD before newly diagnosis of SD.…”

Section: Methodsmentioning

confidence: 99%

“…This definition has been used in previous studies. 18,19 To ensure that the PUD was incident during the follow-up period, we excluded participants with pre-existing PUD before newly diagnosis of SD. We also excluded those who used PPIs or H2 blockers within 3 months before SD diagnosis.…”

Section: Outcome Measuresmentioning

confidence: 99%

Seborrheic dermatitis and risk of incident peptic ulcer disease: A nationwide population‐based cohort study

Chen¹,

Lin

Wang

et al. 2021

Aust J Dermatology

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Background Emerging evidence supports a strong association between the skin and the gut. The association between seborrheic dermatitis (SD) and peptic ulcer disease (PUD) was largely unknown. This study aimed to investigate the association of SD and PUD. Methods This nationwide population‐based cohort study was conducted using the Taiwan's National Health Insurance Research Database. A total of 19 445 participants was recruited. Each patient with a diagnosis of incident SD was matched to four patients without SD using propensity scores based on age, gender, index year, insurance amount, urbanisation level, Charlson comorbidity index (CCI), the presence of comorbidities and medication use. The primary endpoint was the development of incident PUD. Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for PUD occurrence in relation to the presence of SD were calculated. Results Overall, patients with SD had a significantly higher risk for incident PUD than those without SD in both univariable (crude HR = 1.60, 95% CI 1.38–1.86, P < 0.001) and multivariable (adjusted HR = 1.58, 95% CI 1.36–1.83, P < 0.001) Cox proportional hazard regression models. Kaplan–Meier analysis indicated that the cumulative incidence of PUD was consistently higher in individuals with SD than those without SD (log‐rank test, P < 0.001). A higher risk of PUD was also found in individuals with SD than those without SD in all stratified analyses by age, gender, CCI and follow‐up time. Conclusion Patients with SD may have a higher risk for incident PUD. Further studies are warranted to validate our findings.

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“…NHIRD is available for research purposes with appropriate applications. The validity of NHIRD for use in epidemiological cancer research has been shown in the previous publication (17)(18)(19)(20)(21)(22)(23)(24). NHIRD includes patients treated at dedicated veterans' hospitals.…”

Section: Data Sourcesmentioning

confidence: 97%

Older veterans associated with reduced risk of cancer: Retrospective nationwide matched cohort study in Taiwan

et al. 2023

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ImportanceIt remains unknown whether Taiwanese veterans have a lower risk of subsequent cancer compared with non-veterans.ObjectiveTo examine whether veterans are associated with reduced cancer risk.MethodsFrom January 2004 to December 2017, this study included 957 veterans and 957 civilians who were propensity score (PS) matched by years of birth, sex, residence, index year, days in the hospital, frequency of outpatient visits, and relevant comorbidities at baseline. Multivariate Cox proportional hazards regression analysis was applied to compare the risks of cancer, overall and by subgroup, and mortality. All the participants were cancer free at the baseline.ExposuresVeterans retrieved from Taiwan National Health Insurance Research Database (NHIRD).Main outcomeCancer extracted from the Registry for Catastrophic Illness Patients Database (RCIPD).ResultsOverall, 1,914 participants were included, and 957 veterans with a mean (SD) age of 75.9 (6.79) years and 946 men (98.9%). The mean follow-up was about 10.5 (±4.51) years. Cancer was recorded in 6.68% (N = 64) and 12.12% (N = 116) of veterans and non-veterans, respectively. Veterans were associated with decreased risk [adjusted hazard ratio (aHR), 0.57; 95% CI: 0.41–0.78; P < 0.001] of cancer compared with civilians after controlling for age, sex, urbanization, hypertension, diabetes, hyperlipidemia, cardiovascular event, COPD, asthma, chronic liver disease, alcohol-related illness, and Parkinson’s disease. Cancer subgroup analyses verified this finding (HRs <1.0). The decreased incidence rate was predominantly for liver cancer (aHR, 0.18; 95% CI: 0.05–0.72; P < 0.05).ConclusionTaiwanese older veterans are associated with reduced overall cancer risk than individuals without veteran status.

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Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment

Cited by 6 publications

References 42 publications

Is Laryngeal Squamous Cell Carcinoma Related to Helicobacter pylori?

Is Laryngeal Squamous Cell Carcinoma Related to Helicobacter pylori?

Seborrheic dermatitis and risk of incident peptic ulcer disease: A nationwide population‐based cohort study

Older veterans associated with reduced risk of cancer: Retrospective nationwide matched cohort study in Taiwan

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