Risk of high-grade lesions after atypical glandular cells in cervical screening: a population-based cohort study

Norman, Ingrid; Hjerpe, Anders; Dillner, Joakim

doi:10.1136/bmjopen-2017-017070

Cited by 22 publications

(20 citation statements)

References 17 publications

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“…HPV co-testing with cervical cytology has an important role in the triage of cervical squamous lesions; however, its importance is not as clear in glandular pathologies and cervical adenocancer. In a Swedish population-based study, it was reported that the HPV reflex test had a very positive predictive value in the prediction of high-grade cervical lesions in patients with AGCs, and that the planning of a follow-up schedule based on HPV status would be reasonable (13). A systematic review that analyzed the importance of HPV in AGC cytology noted that the hr-HPV test had a sensitivity of 90% in the prediction of CIN-2 and higher lesions in patients with AGC (14).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic importance of atypical glandular cells in cervico-vaginal cytology

Yüksel

Şimşek

Yetkinel

et al. 2020

J Turkish German Gynecol Assoc

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Objective: To analyze the histopathologic outcomes of patients with atypical glandular cells (AGC) in cervicovaginal cytology examinations. Material and Methods:Patients with AGC in cervicovaginal cytology were included in this study between March 2011 and March 2018 and patient data were collected retrospectively among all cytology results. AGC classification of cervicovaginal cytology were based on the Bethesda 2001 classification system. Results:The total prevalence of cervical epithelial cell abnormality and AGC were found as 4.2% and 0.2%, respectively, in the study cohort.AGC-favor neoplasia (AGC-FN) was the subgroup of AGC with the highest malignancy rate with 62.5% (p=0.06). The incidence of malignancy in the postmenopausal group (33.3%) was detected higher than in the premenopausal group (8.3%) (p=0.07). Conclusion:The probability of malignancy in AGC-FN cytology is more commonly associated with malignancy in the postmenopausal group.Therefore, histopathologic examination is strongly recommended in these patients with AGC smears because of the high risk for malignancy in this group. (J Turk Ger Gynecol Assoc 2020; 21: 102-6)

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic importance of atypical glandular cells in cervico-vaginal cytology

Yüksel

Şimşek

Yetkinel

et al. 2020

J Turkish German Gynecol Assoc

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“…33,34 On the other hand, these abnormalities can be associated with benign conditions, such as tubal metaplasia, tubular hyperplasia or polyps. 35 One study from Ireland showed that out of 146 women referred to colposcopy following a single AGC with histologic results, 30 (20.5%) were diagnosed with CIN 2 (CIN 2, CIN 3, adenocarcinoma and cancer). 36 In our study, the CIN 2 prevalence for the women submitted to biopsy due to AGC was 12.5%.…”

Section: Discussionmentioning

confidence: 99%

“…Human papillomavirus was analyzed by HC2 assay (Qiagen, Gaithersburg, Maryland, EUA) for group B viruses (16,18,31,33,35,39,48,51,52, 56, 58, 59 and 68) using the residual LBC specimen, according to the instructions of the manufacturer. The viral load was determined through the quantification of light emission and expressed as a relation of the relative light unit (RLU) with the positive control (PCB), RLU/PCB.…”

Section: Hybrid Capturementioning

confidence: 99%

High-risk Human Papillomavirus Testing for Triage of Women with Previous Cytological Abnormalities from the Vale do Ribeira Region

Lorente

Fernandes

Etlinger-Colonelli

et al. 2020

Rev Bras Ginecol Obstet

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Objective To evaluate the performance of the hybrid capture 2 (HC2) high-risk papillomavirus (hrHPV) assay and cytological test in women with previous abnormalities, to detect cervical intraepithelial neoplasia grade 2 or worse (≥ CIN 2). Methods A cytological test and HC2 (Qiagen, Gaithersburg, Maryland, EUA) for hrHPV were conducted in 359 liquid-based (Sure Path, Becton Dickinson, TriPath Imaging, Burlington, NC, USA) samples collected from women from the Vale do Ribeira Region, during July 2013 and September 2015 with previous cytology classified as atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (ASC-H), and atypical glandular cells (AGC). The histopathological examination was conducted in 179 women. The performance evaluations were calculated using the “exact” Clopper-Pearson 95% confidence interval (CI) test by MEDCALC (Medcalc Software Ltd, Ostend, Belgium). Results The ≥ CIN 2 frequency was 11.7% (21/179). The HC2 for hrHPV and repeat cytology to detect ≥ CIN 2 obtained, respectively, a sensitivity of 90.5% (95%CI = 69.6–98.8) and 90.5%, (95%CI = 69.6–98.8), a specificity of 65.8% (95% CI = 57.9–73.2) and 43.7% (95%CI = 35.8–51.8), a positive predictive value of 26.0% (95% CI = 21.4–31.3) and 17.6%, (95%CI = 14.9–20.6), and a negative predictive value of 98.1% (95%CI = 93.3–99.5) and 97.2% (95% CI = 90.1–99.2). Conclusion Hybrid capture 2 for hrHPV improves the performance of the detection of ≥ CIN 2, without compromising sensitivity, and provides a greater safety margin to return to the triennial screening of women undergoing follow-up due to previous abnormalities, without underlying ≥ CIN 2.

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“…Histological examination of AGC patients revealed premalignant and malignant lesions in 26 (35.6%) patients. In the literature, this rate varies in a very wide range as 17-100% [8][9][10][11][12][13][14][15][16][17][18][19][20]23,24 . In the study of Marques JP et al 20 the average detection rate of abnormal lesion was 58% 7 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinicopathologic features of patients diagnosed with atypical glandular cells on cervical cytology

Çakmak¹,

Kavak²,

Öge³

et al. 2019

MMJ

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Objective: In our study we aimed to evaluate the clinicopathologic features of patients diagnosed with atyipcal glandular cells on cervical cytology. Method: The records of 9375 patients who were examined in the gynecology outpatient clinic between 2010 and 2018 and underwent cervicovaginal smear were retrospectively reviewed. Seventy-three (0.8%) patients were diagnosed as atypical glandular cells. Colposcopic examination, cervical biopsy, endocervical and endometrial curettage were performed in patients diagnosed with atypical glandular cells. Age, gravida, parity, systemic diseases and clinicopathological features of the patients were examined and recorded Results: Cervical and endometrial abnormal histological findings were detected in 26 (35.6%) of 73 patients with atypical glandular cells. Of these 26 patients, 14 (19.1%) had cervical intraepithelial lesions, 3 (4.1%) had endometrial hyperplasia and 9 (12.3%) had invasive cancer. Five (6.8%) of the 9 patients with the diagnosis of invasive cancer had adenocarcinoma (endocervical and endometrial), in 3 (4.1%) patients cervical squamous carcinoma, and in 1 patient. endocervical lymphoma was observed.The majority of cancers detected in our study were in the age group of 50 years and older. Conclusion: Invasive cancer is seen in 12.3% of the patients diagnosed with atypical glandular cells, and most of these patients are 50 years or older. Therefore patients diagnosed with atypical glandular cell in cervicovaginal smear should be carefully evaluated with all clinical features.

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Risk of high-grade lesions after atypical glandular cells in cervical screening: a population-based cohort study

Cited by 22 publications

References 17 publications

Clinicopathologic importance of atypical glandular cells in cervico-vaginal cytology

Clinicopathologic importance of atypical glandular cells in cervico-vaginal cytology

High-risk Human Papillomavirus Testing for Triage of Women with Previous Cytological Abnormalities from the Vale do Ribeira Region

Evaluation of clinicopathologic features of patients diagnosed with atypical glandular cells on cervical cytology

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