Risk of ischemic placental disease in fresh and frozen embryo transfer cycles

Abstract

Objectives: To evaluate the association of fresh and frozen embryo transfer with the development of ischemic placental disease (IPD), hypothesizing that differences in implantation environment affect placentation and thus pregnancy outcomes. Design: We performed a secondary analysis of a retrospective cohort study of deliveries linked to IVF cycles. Setting: Tertiary hospital and infertility treatment center. Patient(s): We included all women who underwent an autologous IVF cycle and had a live-born infant or an intrauterine fetal demise (IUFD). We excluded women less than 18 years of age. Intervention(s): We compared pregnancies resulting from frozen embryo transfer (frozen) cycles with those resulting from fresh embryo transfer (fresh) cycles. Main Outcome Measure(s): The primary outcome was a composite outcome of IPD or IUFD due to placental insufficiency. Ischemic placental disease included pre-eclampsia, placental abruption, and small for gestational age (SGA). We calculated risk ratios (RRs) and 95% confidence intervals (CIs). Result(s): Compared with fresh cycles, frozen cycles had a lower risk of IPD or IUFD from placental insufficiency (RR 0.75, 95% CI 0.59-0.97). Frozen cycles also conferred a lower risk of SGA than fresh cycles (RR 0.58, 95% CI 0.41-0.81). Risks of pre-eclampsia (RR 1.3, 95% CI 0.84-1.9) and abruption (RR 1.2, 95% CI 0.56-2.4) were similar. Conclusion(s):There was a lower risk of IPD among frozen cycles compared with fresh cycles. This association was largely driven by lower risk of SGA among frozen cycles. (Fertil Steril Ò 2019;111:714-21. Ó2018 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

Uterine artery Doppler in singleton pregnancies conceived after in‐vitro fertilization or intracytoplasmic sperm injection with fresh vs frozen blastocyst transfer: longitudinal cohort study

“…Previous studies have shown a lower risk of SGA and low birth weight in pregnancy conceived following FET as compared to fresh embryo transfer 6,41,42,51 . However, all these studies are limited by a high risk of selection bias, since the characteristics of the women undergoing fresh embryo transfer are different from those undergoing FET.…”

Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?

“… Feng 2012 [ 25 ] Women with various infertile causes 31.02 ± 3.69/ 31.60 ± 3.56 604/ 384 Retrospective study Jan 2009 to Dec 2010 IR, CPR, MR, LBR, MPR, EPR, PTD, LBW, Stil, NM Ferraretti 1999 [ 26 ] Patients at risk of OHSS 31.46 ± 2.4/ 31.66 ± 2.8 67/58 Prospective RCT Jan 1996 to Jul 1997 CPR, LBR, PR Ginström 2019 [ 27 ] Singletons born after in Sweden 34.9 ± 5.2 /34.1 ± 4.3 9726/24,365 Retrospective cohort study 2005 to 2015 GDM, PP, PA, PPH, PIH, Healy 2010 [ 28 ] Women with singleton births in Victoria Australia No statement 4058/2045 Retrospective cohort study 1991 to 2004 PP, PA, PH Henningsen 2011 [ 29 ] Singleton born after fresh ET or FET No statement 716/716 Retrospective cohort study 1994 to 2008 LBW Henman 2005 [ 30 ] Patients with three or more usable blastocysts < 38 years 121/156 Prospective study Apr 2000 to Dec 2001 IR, CPR, LBR, MPR Hwang 2019 [ 31 ] Singleton infants born to Massachusetts women who conceived by fresh or FET No statement 12,390/ 2101 Retrospective cohort study. July 2004, to Dec 2013 Preterm, LGA, SGA, LBW, Birth defects Ishihara 2014 [ 32 ] Women undergoing SET Any age 33,559/118866 (5981/27408 singletons) Retrospective study 2008 to 2010 CPR, MR, MPR, EPR, PP, PA, PIH, LGA, SGA, LBW, HBW, Stil Johnson 2019 [ 33 ] Women who underwent an autologous IVF cycle 35.8 (32.8–38.8)/36.3 (33.0–39.8) …”

Higher gestational weight gain and lower serum estradiol levels on the day of human chorionic gonadotropin administration are associated with increased risk of preeclampsia after in vitro fertilization

“…These findings thus differ from our results. Moreover, a recent publication also reported that the risk of preeclampsia was lower when there was a high peak E2 level [33].…”