Risk of Lung Cancer According to Histologic Type and Cigarette Dosage

Weiss, William A.; Boucot, Katharine R.; Seidman, Herbert; Carnahan, William J.

doi:10.1001/jama.1972.03210070033009

Cited by 57 publications

(11 citation statements)

References 8 publications

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“…Therefore, the individual variability in the response to environmental mutagens may be related to local factors mediated by surfactant function. This hypothesis might be supported by the observation that the association between exogenous exposure to carcinogens has been shown strongest for squamous cell carcinoma of the lung (Breslow et al, 1954;Weiss et al, 1972) and the relative risk with increasing duration of exposure rise fastest in this type of lung cancer. But, as SCLC is also related to tobacco smoke and other exogenous substances, the differences in SP-B variants in SCC and SCLC might be due to statistical reasons because of small groups.…”

Section: Genetics and Genomicsmentioning

confidence: 94%

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients

Seifart

Plagens

et al. 2002

Br J Cancer

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Genetic factors are thought to influence the risk for lung cancer. Since pulmonary surfactant mediates the response to inhaled carcinogenic substances, candidate genes may be among those coding for pulmonary surfactant proteins. In the present matched case -control study a polymorphism within intron 4 of the gene coding for surfactant specific protein B was analysed in 357 individuals. They were divided into 117 patients with lung cancer (40 patients with small cell lung cancer, 77 patients with non small cell lung cancer), matched controls and 123 healthy individuals. Surfactant protein B gene variants were analysed using specific PCR and cloned surfactant protein B sequences as controls. The frequency of the intron 4 variation was similar in both control groups (13.0% and 9.4%), whereas it was increased in the small cell lung cancer group (17.5%) and the non small cell lung cancer group (16.9%). The gene variation was found significantly more frequently in patients with squamous cell carcinoma (25.0%, P=0.016, odds ratio=3.2, 95%CI=1.24 -8.28) than in the controls. These results indicate an association of the surfactant protein B intron 4 variants and/or its flanking loci with mechanisms that may enhance lung cancer susceptibility, especially to squamous cell carcinoma of the lung.

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Section: Genetics and Genomicsmentioning

confidence: 94%

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients

Seifart

Plagens

et al. 2002

Br J Cancer

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“…A similar excess had been previously shown to exist among the subcohort of employees exposed to VCM (1). Thus, the excess lung cancer risk at the plant appeared to be independent of VCM exposure unless one hypothesized that it was due to extremely low levels (14,(20)(21)(22) Large cell undifferentiated carcinoma of the lung is the only major histologic type that has appeared to be unrelated to cigarette smoking. Thus, cigarette smoking was probably not a major confounding variable.…”

Section: Discussionmentioning

confidence: 63%

Excess Lung Cancer Risk in a Synthetic Chemicals Plant

Waxweiler¹,

Smith²,

Falk³

et al. 1981

Environmental Health Perspectives

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“…Some early studies showed no or only slight association between smoking and adenocarcinoma (Kreyberg, 1969;Doll & Hill, 1964). Other studies, however, have strongly suggested that smoking also increases the risk for adenocarcinoma (Haenszel et al, 1962;Weiss et al, 1972;Stayner & Wegman, 1983). In the present study, a significantly increased relative risk was estimated for this tumour group but it was considerably lower than for small cell and epidermoid carcinoma.…”

Section: Discussionmentioning

confidence: 99%