Risk of Lung Cancer following Nonmalignant Respiratory Conditions among Nonsmoking Women Living in Shenyang, Northeast China

Lee, Hui; Guan, Peng; Yin, Zhihua; Li, Xuelian; He, Qincheng; Zhou, Baosen

doi:10.1089/jwh.2008.1355

Cited by 27 publications

(23 citation statements)

References 34 publications

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“…Since WLB examination was quite reliable and accurate, and it should be the initial clinical investigation once clinical features indicate possible bronchial lesion in chest [18]. The female cases had a higher incidence of adenocarcinoma (50.2%) than small cell carcinoma (34.2%), which is consistent with earlier findings related to the occurrence of lung cancer type in female subjects [11,19,20]. We also observed a yearly increase in the incidence of squamous cell carcinoma among female subjects, perhaps due to the increase of female smoking behavior in China recently [21,22] (Table 2).…”

Section: Discussionsupporting

confidence: 87%

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Gao

Asmitanand²,

Ren³

et al. 2012

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White light bronchoscopy [WLB] has been used for identification and localization of intra-epithelial pre-neoplastic and neoplastic lesions within the bronchus. Aim of the study was to evaluate the uses of WLB to detect and localize the precancerous and cancerous lesions, and in addition to analyze morphologic presentation, and association to histological type and the variation between genders.A total of 4983 patients were examined by WLB from 2004 to 2009 in a local tertiary teaching hospital. The following parameters were collected: morphological presentation, biopsy sites, histology. The patients' records of age, sex, smoking status, blood-gas, X-RAY/CT, CBC, ECG, PT, and APTT were obtained for analysis. Differences between the patients groups were analyzed using Chi square test.1489 patients who had hyperplasia or neoplasic lesions were further confirmed as having lung cancer pathologically. Lung cancer was more commonly found in the right lung (51.58% vs 42.82%). The upper lobe was more frequently found to have lesions (44.17% vs 22.42%) than the lower lobe. Male patients with squamous cell carcinoma showed more commonly upper lobe involvement, while left main bronchus was more commonly involved in female patients. Adenocarcinoma was mostly involved in lesions of the upper lobe. Proliferative type was found in 80.15% of squamous cell carcinoma cases and in 76.16 % of small cell carcinoma cases.Fiberoptic bronchoscopy is an effective method for the detection of preinvasive neoplasic lesions. The morphological presentation is associated to histological type. There is variation in presentation and histology of cancerous lung lesion between the genders.

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Section: Discussionsupporting

confidence: 87%

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Gao

Asmitanand²,

Ren³

et al. 2012

neo

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“…Nineteen of the studies were conducted in North America [17], [29], [30], [39], [45], [46], [48], [51], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], 12 were conducted in Asia [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], 6 in Europe [28], [47], [50], [85], [86], [87] and 1 in Africa [88]. The combined relative risk (RR) of lung cancer based on all 59 effect estimates was 1.83 (95% confidence interval (CI): 1.60, 2.11).…”

Section: Resultsmentioning

confidence: 99%

“…Eleven of the studies were conducted in the North America [17], [29], [39], [56], [62], [63], [64], [65], [67], [69], [70], 15 were conducted in Asia [73], [74], [75], [76], [77], [78], [79], [80], [83], [84], [92], [93], [94], [95], [96] and 4 were conducted in Europe [27], [85], [86], [90]. The observed effect across all the identified studies suggests an increased risk of lung cancer from tuberculosis (RR = 1.76, 95% CI: 1.49, 2.08).…”

Section: Resultsmentioning

confidence: 99%

Previous Lung Diseases and Lung Cancer Risk: A Systematic Review and Meta-Analysis

2011

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BackgroundIn order to review the epidemiologic evidence concerning previous lung diseases as risk factors for lung cancer, a meta-analysis and systematic review was conducted.MethodsRelevant studies were identified through MEDLINE searches. Using random effects models, summary effects of specific previous conditions were evaluated separately and combined. Stratified analyses were conducted based on smoking status, gender, control sources and continent.ResultsA previous history of COPD, chronic bronchitis or emphysema conferred relative risks (RR) of 2.22 (95% confidence interval (CI): 1.66, 2.97) (from 16 studies), 1.52 (95% CI: 1.25, 1.84) (from 23 studies) and 2.04 (95% CI: 1.72, 2.41) (from 20 studies), respectively, and for all these diseases combined 1.80 (95% CI: 1.60, 2.11) (from 39 studies). The RR of lung cancer for subjects with a previous history of pneumonia was 1.43 (95% CI: 1.22–1.68) (from 22 studies) and for subjects with a previous history of tuberculosis was 1.76 (95% CI = 1.49, 2.08), (from 30 studies). Effects were attenuated when restricting analysis to never smokers only for COPD/emphysema/chronic bronchitis (RR = 1.22, 0.97–1.53), however remained significant for pneumonia 1.36 (95% CI: 1.10, 1.69) (from 8 studies) and tuberculosis 1.90 (95% CI: 1.45, 2.50) (from 11 studies).ConclusionsPrevious lung diseases are associated with an increased risk of lung cancer with the evidence among never smokers supporting a direct relationship between previous lung diseases and lung cancer.

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“…[19] The female cases had a higher incidence of adenocarcinoma (49.85%) and small cell carcinoma (34.42%), which is in agreement with earlier findings related to the occurrence of lung cancer type in female subjects. [112021] We also observed a yearly increase in the incidence of squamous cell carcinoma among female subjects, perhaps increasingly popular smoking behavior is an explanation[2223] [Table 2]. …”

Section: Discussionmentioning

confidence: 86%

“…The high incidence of lung cancer among elderly subjects may be related to factors like smoking status, food habits, occupational exposure and infectious diseases. [202124–26] Moreover, the lack of observed gender predisposition for lung cancer types among subjects more than 50 years of age supplements ours assumption that the elderly in China are predisposed to malignancy. [27] Bronchial carcinomas typically involve the main, middle and segmental bronchus.…”

Section: Discussionmentioning

confidence: 99%

Descriptive data on cancerous lung lesions detected by auto-fluorescence bronchoscope: A five-year study

et al. 2012

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BACKGROUND:Auto-fluorescence bronchoscopy (AFB) has been used for the identification and localization of intra-epithelial pre-neoplastic and neoplastic lesions within the bronchus.OBJECTIVES:To determine the applicability of AFB for the detection and localization of precancerous and cancerous lesions, in addition to analyzing the morphologic presentation, their association to histological type and the variation between genders.METHODS:A five-year study involving 4983 patients, who underwent routine bronchoscopy [B] examination in a local tertiary teaching hospital, was done. The B examination was performed under intratracheal lidocaine, and samples were obtained using suitable approach. One thousand four hundred and eighty-five pathologically confirmed lung cancer patients were included in the study. The following parameters were studied: Morphological presentation, biopsy sites, histology. Differences between the groups were analyzed using Chi square test.RESULT:One thousand four hundred and eighty-five patients who had hyperplasia or neoplastic lesions were further confirmed as lung cancer pathologically. Lung cancer was more commonly found in the right lung (51.58% vs. 42.82%). The lesion occurred more frequently in the upper lobe than the lower lobe (44.17% vs. 22.42%). Male patients with squamous cell carcinoma showed upper lobe involvement more commonly, while the left main bronchus was more commonly involved in female patients. Adenocarcinoma mostly involved lesion of the upper lobe. Squamous cell carcinoma and small cell carcinoma were the major proliferative types (80.15% and 76.16% respectively).CONCLUSION:AFB is efficient in the detection of pre-invasive and invasive lung lesions. The morphological presentation is associated to the histological type. There is variation in the presentation and histology of cancerous lung lesions between genders.

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Risk of Lung Cancer following Nonmalignant Respiratory Conditions among Nonsmoking Women Living in Shenyang, Northeast China

Abstract: This study strengthens the evidence linking NMRCs, especially pulmonary tuberculosis, to lung cancer even in lifelong nonsmoking women.

Cited by 27 publications

References 34 publications

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Previous Lung Diseases and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Descriptive data on cancerous lung lesions detected by auto-fluorescence bronchoscope: A five-year study

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Risk of Lung Cancer following Nonmalignant Respiratory Conditions among Nonsmoking Women Living in Shenyang, Northeast China

Abstract: This study strengthens the evidence linking NMRCs, especially pulmonary tuberculosis, to lung cancer even in lifelong nonsmoking women.

Cited by 27 publications

References 34 publications

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Previous Lung Diseases and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Descriptive data on cancerous lung lesions detected by auto-fluorescence bronchoscope: A five-year study

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Product

Resources

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Fiber-optic bronchoscope and detection of lung cancer: A five year study

Fiber-optic bronchoscope and detection of lung cancer: A five year study