Risk of Lymphoproliferative Malignancy in Relation to Small Intestinal Histopathology Among Patients With Celiac Disease

Abstract

The risk of lymphoproliferative malignancy in celiac disease is dependent on small intestinal histopathology, with no increased risk in latent celiac disease.

Age-related differences in celiac disease: Specific characteristics of adult presentation

“…The lack of dietary compliance and persistence of histological damage, are two factors associated with the development of lymphoproliferative disease in adults, which is the most severe complication associated to CD [34] . A recent Swedish population study noted that celiac patients with persistent villous atrophy, during follow-up, had twice the risk of developing a malignant lymphoproliferative disease, mostly T lymphoma [35] .…”

Mujer anciana con diarrea crónica

“…Por otro lado, se ha descrito déficit de vitamina D hasta en el 66% de los pacientes 12 que se asocia a un mayor riesgo de fracturas, aunque debido a la gran heterogeneidad en los estudios, se recomienda investigar de una manera más amplia 13 También se ha asociado la EC con un riesgo dos veces mayor de padecer enfermedades malignas, especialmente linfomas no Hodgkin, tanto de células B como T, con un pico de incidencia en la séptima década de la vida. Parece que este riego no está aumentado en EC latente 14 . Más dudosa es su asociación con tumores sólidos en distintas localizaciones (esófago, páncreas, intestino delgado, colon, vía biliar) 1 ya que el riesgo no va más allá del primer año de seguimiento 14 .…”

“…Parece que este riego no está aumentado en EC latente 14 . Más dudosa es su asociación con tumores sólidos en distintas localizaciones (esófago, páncreas, intestino delgado, colon, vía biliar) 1 ya que el riesgo no va más allá del primer año de seguimiento 14 .…”

Commentary: coeliac disease, mortality and malignancy

“…6 Including patients with confirmed normal histopathology (but positive coeliac disease serology) in their study therefore risks underestimating the true risk of death and malignancy in coeliac disease. 7 (iii) British data suggest that internal comparisons are better than external comparisons.…”

“…[3][4][5] Our serology-only mortality analysis includes the screening studies but also includes Ludvigsson et al 6 which examined a population of serology-positive, biopsy-negative patients that were not screened. In contrast to the screening studies, Ludvigsson et al found that serology-positive, biopsy-negative patients had an increased risk of mortality.…”