Risk of non-arteritic anterior ischaemic optic neuropathy (NAION) after cataract extraction in the fellow eye of patients with prior unilateral NAION

Lam, Byron L.; Jabaly-Habib, Haneen; Al-Sheikh, Nabih; Pezda, M. S.; Guirgis, Medhat F.; Feuer, William J.; McCulley, Timothy J.

doi:10.1136/bjo.2006.0107276

Cited by 56 publications

(44 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the remaining 308 patients who had no cataract surgery in the eye contralateral to that which experienced spontaneous NAION, 59 (19%) experienced spontaneous NAION in that eye. Using these data, Lam et al 55 calculated that the risk of a post-cataract extraction anterior optic neuropathy was 3.6 times higher in patients who had experienced an attack of spontaneous NAION in the other eye compared with patients who had not had an attack of spontaneous NAION and concluded that the anterior optic neuropathy that occurs shortly after uncomplicated cataract extraction is, indeed, a form of NAION.…”

Section: Risk Factorsmentioning

confidence: 99%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

191

139

View full text Add to dashboard Cite

Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerve-related visual loss in adults after glaucoma. Patients typically present with acute, painless, unilateral loss of vision associated with a variable visual field defect, a relative afferent pupillary defect, a swollen, hyperaemic optic disc, and one or more flame-shaped peripapillary retinal haemorrhages. The pathogenesis of this condition is unknown, but it occurs primarily in patients with structurally small optic discs that have little or no cup and a variety of underlying vascular disorders that may or may not be known at the time of visual loss. There is no consistently beneficial medical or surgical treatment for the condition, but there are now animal models that allow testing of various potential therapies. About 40% of patients experience spontaneous improvement in visual acuity. Patients in whom NAION occurs in one eye have a 15-19% risk of developing a similar event in the opposite eye over the subsequent 5 years.

show abstract

Section: Risk Factorsmentioning

confidence: 99%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

191

139

View full text Add to dashboard Cite

show abstract

“…This could be related to intraocular pressure fluctuations, locally released vasoactive peptides and systemic prothrombotic and/or proinflammatory factors all somehow influenced by the surgical procedure. [1][2][3] However, the prevalence of hypertension and small cup-todisc ratio was notably lower in patients with NAION following lens-related intraocular surgery than in those with spontaneous NAION, indicating that risk factors for NAION in these settings may be different. 7 The incidence of NAION occurring in the contralateral eye was found to vary between 24% and 48%, within a period of 5-11 years.…”

Section: Discussionmentioning

confidence: 85%

“…3 The incidence of the delayed-type CE-associated NAION was found to be higher than the immediate type, with the latter being linked to raised intraocular pressure during the operative and perioperative periods in the affected patients. It could not be determined with certainty, however, that the NAION experienced after cataract extraction was not due to coincidental spontaneous NAION.…”

Section: Discussionmentioning

confidence: 99%

“…8 A retrospective study published in 2007 challenged the previous notion that CE-associated NAION was unrelated to prior NAION in the fellow eye. 3 The relevant study included a total 325 patients. Seventeen of them underwent cataract surgery in the fellow eye, and 53% developed NAION.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of the delayed type was found to be higher than the immediate type. 2,3 We present a case of delayed-type NAION occurring after uneventful phacoemulsification cataract surgery in a susceptible individual.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Non-arteritic Anterior Ischaemic Optic Neuropathy after Uneventful Cataract Extraction

Emeriewen¹,

Kadare²,

Tsatsos

et al. 2016

Neuro-Ophthalmology

View full text Add to dashboard Cite

We present the case of a 74-year-old Caucasian female who suffered sudden visual loss after routine phacoemulsification cataract surgery. The patient was subsequently diagnosed with nonarteritic anterior ischaemic optic neuropathy. The case is described in detail, and a concise review of the literature is presented together with the authors' view on the subject outlined. This is a very rare complication after cataract surgery even in high-risk patients with associated systemic comorbidities. We suspect that the previous history of obesity, coronary artery disease, and arteriosclerosis contributed to the development of this serious ocular complication. We suggest appropriate measures to reduce the risk of its occurrence. ARTICLE HISTORY

show abstract

Association of Nonarteritic Ischemic Optic Neuropathy With Obstructive Sleep Apnea Syndrome

et al. 2015

View full text Add to dashboard Cite

The prevalence of obstructive sleep apnea syndrome (OSAS) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and its influence on second eye involvement is not well known. OBJECTIVE To evaluate the prevalence of OSAS in patients with NAION and risk factors of second eye involvement. DESIGN, SETTING, AND PARTICIPANTS In this cohort study, we examined 118 patients with anterior ischemic optic neuropathy referred to a tertiary care center from January 1, 2003, through December 31, 2010. EXPOSURES Patients underwent polysomnography to detect OSAS and were prospectively followed up to assess the risk of second eye involvement. MAIN OUTCOMES AND MEASURES The prevalence of OSAS in patients with NAION and the risk of second eye involvement using survival analysis based on the presence of OSAS, indication for ventilation treatment with continuous positive airway pressure, and other potential ocular and systemic confounders. RESULTS In 89 patients with NAION who underwent polysomnography, 67 (75%) had OSAS. Second eye involvement was found in 10 (13.7%) of 73 patients at 3 years: 8 (15.4%) of 52 patients with OSAS at 3 years and 2 (9.5%) of 21 patients without OSAS at 3 years; P = .04. In multivariate analysis, nonadherence to ventilation treatment with continuous positive airway pressure in patients with severe OSAS increased the risk of second eye involvement (hazard ratio, 5.54; 95% CI, 1.13-27.11; P = .04). CONCLUSIONS AND RELEVANCE These results suggest that OSAS is common in patients with NAION and that polysomnography should be considered in these patients. These findings also suggest that patients with severe OSAS who are nonadherent to ventilation treatment with continuous positive airway pressure have an increased risk of second eye involvement.

show abstract

Risk of non-arteritic anterior ischaemic optic neuropathy (NAION) after cataract extraction in the fellow eye of patients with prior unilateral NAION

Cited by 56 publications

References 11 publications

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Non-arteritic Anterior Ischaemic Optic Neuropathy after Uneventful Cataract Extraction

Association of Nonarteritic Ischemic Optic Neuropathy With Obstructive Sleep Apnea Syndrome

Contact Info

Product

Resources

About