Risk of nonsyndromic cleft lip and palate in relatives of women with breast cancer

Martelli, Daniella Reis Barbosa; Vieira, Alexandre R.; Fonseca, A; Coletta, Ricardo D.; Soares, Priscila Bernardina Miranda; Martelli‐Júnior, Hercílio

doi:10.1002/ajmg.a.36186

Cited by 9 publications

(12 citation statements)

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“…There is also evidence that families with children diagnosed with acute lymphoblastic leukemia reported a family history of clefts more often than control families (Jindal and Vieira, ). However, there are also several studies that failed to show such correlations (Steinwachs et al, ; Dietz et al, ; Martelli et al, ). Identification of common etiologic factors for both cancer and orofacial clefts may help to identify CL/P individuals at greatest risk of having cancer in their lifetime.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants in BRIP1 (BACH1) contribute to risk of nonsyndromic cleft lip with or without cleft palate

Mostowska

Hozyasz

Wójcicki

et al. 2014

Birth Defects Research

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Section: Discussionmentioning

confidence: 99%

Genetic variants in BRIP1 (BACH1) contribute to risk of nonsyndromic cleft lip with or without cleft palate

Mostowska

Hozyasz

Wójcicki

et al. 2014

Birth Defects Research

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“…Dietz et al (2012) analyzed the risk of breast cancer in families with NSCL/P, but they were unable to confirm a general increase of breast cancer risk among female subjects in families with clefts (18). analyzed the risk of NSCL/P in families of women with breast cancer, but they were unable to confirm a general increase in the risk of NSCL/P among families of women with breast cancer (8).…”

Section: Discussionmentioning

confidence: 99%

“…About 70% of the cases occur as a nonsyndromic form (NSCL/P), and the remaining 30% are associated with Mendelian disorders or chromosomal, teratogenic and sporadic conditions (7). Although there has been marked progress in identifying environmental and genetic risk factors associated with NSCL/P, its etiology in most of the cases remains unclear (4,8). Based on epidemiological features and embryologic timing, NSCL/P are traditionally divided in nonsyndromic cleft lip (NSCL), nonsyndromic cleft lip and palate (NSCLP) and nonsyndromic cleft palate (NSCP) (9).…”

Section: Introductionmentioning

confidence: 99%

“…A study published in 2015 showed that having an oral cleft increases the risk for self-reported history of cancer in family members, and genetic variants in DLX1 and MMP3 are associated with oral cleft regardless of the history of cancer (10). Over the past years, epidemiological studies have assessed the relationship between cancer and NSCL/P in different populations [Texas, USA (11), Southeast Asian (12), Denmark (13), Pittsburgh, USA (14), Latvia (15), India (16), The Netherlands (17), Danish (18), Turkey (19), Brazil (20), France (21), Brazil (8,22), Poland (23), Pakistan (24), Brazil (25)], and the results are controversial.…”

Section: Introductionmentioning

confidence: 99%

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Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

Fonseca¹,

Martelli²,

Almeida³

et al. 2019

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Objective: To evaluate the occurrence of nonsyndromic cleft lip and/or palate (NSCL/P) in families of patients with prostate cancer (PC).Study design: We conducted a case-control study involving a total of 748 individuals, 280 of which had PC, and 468 were free-cancer healthy individuals. The patients answered a questionnaire with basic demographic information and family history of NSCL/P in first-degree relatives. The information collected was stored in a database and analyzed by using the statistical program SPSS® 24.0 for Windows (Chicago, IL, USA). In order to determine the association with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant.Results: Of total patients with PC, 2 had a positive history of NSCL/P. In the control group, 7 patients reported family history of NSCL/P (1df chi-square, p=0.34; Fisher´s exact test, p=0.49). The average age of the cases diagnosed with PC was 71.35±7.70 years, and control group was 64.42±9.67 years.Conclusion: Despite the limited population, the frequency of NSCL/P was not significantly increased in the first-degree relatives of patients with PC. Studies with larger samples and molecular analyses are needed to better understand the possible relationships in the etiology of cancer and NSCL/P.

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“…The concept is that genes acting during the normal development may also have an important role in malignancies [6]. Over the past years, epidemiological studies have investigated the association of cancer with NSOC in different populations, including those from the United States, Southeast Asia, Denmark, Latvia, India, the Netherlands, Turkey, France, Poland, Pakistan, and Brazil [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], and the results are controversial. Thus, the aim of this study was to determine the frequency of NSOC in families of patients with a diagnosis of ALL.…”

Section: Introductionmentioning

confidence: 99%

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

et al. 2020

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Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, n = 50) and controls (n = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher’s exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61–274.6, p = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological relationship between cancer and nonsyndromic oral clefts.

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Risk of nonsyndromic cleft lip and palate in relatives of women with breast cancer

Abstract: © 2013 Wiley Periodicals, Inc.

Cited by 9 publications

References 20 publications

Genetic variants in BRIP1 (BACH1) contribute to risk of nonsyndromic cleft lip with or without cleft palate

Genetic variants in BRIP1 (BACH1) contribute to risk of nonsyndromic cleft lip with or without cleft palate

Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

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