Risk of osteoporotic fractures in multiple sclerosis patients in southwest Finland

Åivo, Julia; Kurki, Samu; Sumelahti, Marja Liisa; Hänninen, Katariina; Ruutiainen, Juhani; Soilu‐Hänninen, Merja

doi:10.1111/ane.12623

Cited by 12 publications

(11 citation statements)

References 38 publications

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“…Our study is retrospective, and the duration of follow‐up was rather short for condition like MS, only 5 years. However, it does show an increasing prevalence of MS compared to the result of the previous study in SwF from 2012 …”

Section: Discussioncontrasting

confidence: 61%

“…Finland has been known to be a country of high MS risk, and our results support this. The 280/100 000 age‐standardized (ESP) prevalence of MS in SwF is among the highest in the world and has increased significantly during the past four years . Furthermore, the crude incidence rate of 11.7/100 000 is similar to other high‐risk regions in Finland confirming that southwest Finland is a hotspot of multiple sclerosis in Finland.…”

Section: Discussionmentioning

confidence: 75%

“…There are, however, no nationwide statistics on the prevalence and incidence of MS, and there are no epidemiological data on the eastern part of the country. The regional prevalence of MS in southwest Finland was recently reported; it was even higher (213/100 000) than what has been reported as the nationwide rates in Sweden and Norway . The incidence in southwest Finland is unknown.…”

Section: Introductionmentioning

confidence: 80%

“…The diagnosis of MS patients is centralized to Turku University Hospital in SwF region and to North Karelia Central Hospital in NK region. All patient records with an ICD‐10 (International Statistical Classification of Diseases and Related Health Problems—Tenth Revision) diagnostic code of MS (ICD‐10: G35) were identified by searching the hospital administrative data in SwF as described previously . In NK, the hospital discharge registry was searched, leading to identification of persons who had visited the hospital either as inpatients or as outpatients with the diagnostic code of MS during 2012‐2016.…”

Section: Methodsmentioning

confidence: 99%

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Multiple sclerosis epidemiology in Finland: Regional differences and high incidence

2019

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Objectives Studies on the east‐west gradient of multiple sclerosis (MS) are scarce. In Finland, epidemiological differences have been only partially elucidated, but the MS risk is high, and it has been claimed that the occurrence follows a longitudinal gradient. In this register‐based study, we updated the MS epidemiology in southwest Finland (SwF) and compared it to the easternmost hospital district, North Karelia (NK), for which no previous data exist. Materials and methods Patients with ICD‐10 code G35 were identified from hospital district administrative data. Patient records were reviewed to include only cases with a definitive diagnosis. Incidence period covered 5 years (2012‐2016), and the prevalence date was December 31, 2016. Results were standardized using the direct method. Results A total of 1184 persons had MS in SwF and 253 persons in NK at the end of 2016. The prevalence was 280/100 000 (95% CI 264‐296) in SwF and 168/100 000 (95% CI 148‐190) in NK (age‐standardized for the European standard population 2013). During the incidence period, 211 new MS diagnoses were made in SwF and 49 in NK. The annual age‐standardized (ESP 2013) incidence was 12.1/100 000 person‐years (95% CI 10.5‐13.8) in SwF and 8.6/100 000 person‐years (95% CI 6.4‐11.2) in NK in the age‐group 10‐69 years. Conclusions There are regional differences in MS epidemiology in Finland, possibly related to demographic, social, and genetic circumstances, but the retrospective nature and limited sample size of this study might introduce some uncertainty to the calculations. SwF is a region with a globally very high risk for MS.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

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Multiple sclerosis epidemiology in Finland: Regional differences and high incidence

2019

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“…Finland is a high‐risk multiple sclerosis (MS) region based on regional studies, but nationwide MS prevalence studies have not been performed recently. A national MS register was launched in 2014, which enables systematic follow‐up of incidence and prevalence figures as well as many clinical variables.…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis in Finland 2018—Data from the national register

et al. 2019

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Objectives:Finland is a high-risk multiple sclerosis (MS) region, but a national MS register has not existed until 2014. In this paper, we present the Finnish MS register variables and data collected by 31 December 2018. Materials and Methods:Numbers and data counts of MS patients in the register (ICD-10 code G35) are presented. The disease types and proportion of patients receiving disease-modifying treatments (DMTs) were analysed in five hospital districts with most complete data sets. MS prevalence in Finland was estimated using administrative hospital discharge data as an additional resource.Results: There were a total of 8722 MS patients in the Finnish MS register by 31December 2018 (71.5% females). Mean age at MS diagnosis was 38.7 years and peak prevalence was at age 50-54 years. Disease course was relapsing remitting (RRMS) in 66.7%, secondary progressive (SPMS) in 13.5%, and primary progressive (PPMS) in 7.9% of the 5365 MS patients in the selected districts with most complete data. A total of 66.0% of RRMS patients, 19.6% of SPMS patients and 9.9% of PPMS patients were receiving DMTs. By combining MS register data with databases of those hospitals that had not joined the register, the nationwide prevalence estimate was between 10 and 11 thousand patients (corresponding to crude prevalence 180-200/100 000). Conclusions:The Finnish MS register is currently used in 15/21 Finnish hospital districts. By register integration into the electronic patient files, the coverage of the register has increased to approximately 80% of the estimated Finnish MS population.

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Multiple sclerosis in the elderly: a retrospective cohort study

Zinganell,

Göbel,

Berek

et al. 2023

J Neurol

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Risk of osteoporotic fractures in multiple sclerosis patients in southwest Finland

Abstract: We observed high prevalence of MS in southwest Finland and confirmed increased age-adjusted comorbid risk for osteoporotic fractures and other low-energy fractures compared with individually matched controls.

Cited by 12 publications

References 38 publications

Multiple sclerosis epidemiology in Finland: Regional differences and high incidence

Multiple sclerosis epidemiology in Finland: Regional differences and high incidence

Multiple sclerosis in Finland 2018—Data from the national register

Multiple sclerosis in the elderly: a retrospective cohort study

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