Risk of Phthalate Exposure among Hospitalized Patient via Intravenous Fluids Receiving

Rastegari, Forouz; Amin, Mohammad Mehdi; Ebrahimpour, Karim

doi:10.29252/arakmu.11.3.33

Cited by 3 publications

(8 citation statements)

References 19 publications

(23 reference statements)

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“…Furthermore, the surface area of the product that comes into contact with the solution can affect the amount leached. The average concentration of DEHP in IV infusion fluids was 1.55 μg/L, indicating that each liter of fluid contains 1.55 μg DEHP, which was lower than the value reported earlier for IV infusion fluid stored in the polyethylene terephthalate (PET) container (10 μg/L) …”

Section: Resultscontrasting

confidence: 62%

“…The proportion of DEHP, DEP, DiBP, and DBP found in IV fluids was 88, 5.6, 3.6, and 2.5%, respectively. DEP, DiBP, and DBP were also found in plastic package made of PET . Phthalate exposures via first aid products were mainly contributed by DEHP (60%), DBP (20%), and DiBP (12%).…”

Section: Resultsmentioning

confidence: 97%

“…The measured concentrations of DEHP in medical devices and IV fluids were lower than those reported in earlier studies (Table S3). ,,,,,,− The highest exposure doses to DEHP were reported from blood transfusions (using preserved blood in PVC blood bags) or hemodialysis . Different types of plastic materials have been reported to leach phthalates differently .…”

Section: Resultsmentioning

confidence: 99%

“…The average concentration of DEHP in IV infusion fluids was 1.55 μg/L, indicating that each liter of fluid contains 1.55 μg DEHP, which was lower than the value reported earlier for IV infusion fluid stored in the polyethylene terephthalate (PET) container (10 μg/L). 13 3.1.4. Leaching from First Aid Supplies.…”

Section: Resultsmentioning

confidence: 99%

“…Phthalates, esters of ortho -phthalic acid, are widely used as plasticizers to improve the flexibility of polyvinyl chloride (PVC) plastics . Phthalates are present in consumer products, including personal care products (PCPs), pharmaceuticals, and medical devices. − For over two decades, studies have shown that phthalates are reproductive and developmental toxicants and elicit carcinogenic, cardiotoxic, hepatotoxic, and nephrotoxic effects in laboratory animals. − The effects of phthalates on the human endocrine system, especially on reproduction, are well documented. , Di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) are reproductive toxicants. , DEHP has been widely used as a plasticizer in medical devices. ,− Nevertheless, it is not known whether other phthalate diesters such as diethyl phthalate (DEP) and butyl benzyl phthalate (BzBP) are used in medical devices…”

Section: Introductionmentioning

confidence: 99%

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Leaching of Phthalates from Medical Supplies and Their Implications for Exposure

Wang

2023

Environ. Sci. Technol.

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In this study, 72 single-use medical products, grouped into four categories, namely, creams/liquids (n = 8), medical devices (n = 46; 15 of 46 labeled "di(2-ethylhexyl)phthalate (DEHP)-free"), first aid products (n = 13), and intravenous (IV) infusion/irrigation fluids (n = 5), were collected from an intensive care unit in a hospital in New York State in 2015 and analyzed for the migration of 10 phthalates in ethanol/water (1:1) mixture for 1 h. The total phthalate concentration (Σ phthalates ) leached from medical products ranged from 0.04 to 54,600 μg. DEHP was the major phthalate found in 99% of the samples analyzed, with the highest amount leached from respiratory support devices (median: 6560 μg). DEHP was also found at notable concentrations in products labeled as "DEHP-free". Direct exposure to phthalates from the use of medical devices and first aid supplies and dermal intake from the use of creams/ lotions were calculated. The highest DEHP exposure dose of 730 μg/kg bw/day was determined from the use of cannula for neonates. This is the first study to document the amount of phthalates leached from various medical supplies and associated exposures.

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Section: Resultscontrasting

confidence: 62%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Leaching of Phthalates from Medical Supplies and Their Implications for Exposure

Wang

2023

Environ. Sci. Technol.

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Adsorption and Leachable Contamination of Flucloxacillin, Cyclosporin and Amiodarone Following Delivery Through an Intravenous Administration Set

et al. 2018

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Detection of Dibutyl Phthalate in Surface Water by Fluorescence Polarization Immunoassay

Mukhametova,

Karimova,

Zharikova

et al. 2023

Biosensors

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Dibutyl phthalate (DBP) is widely used as a plasticizer in the production of polymeric materials to give them flexibility, strength and extensibility. However, due to its negative impact on human health, in particular reproductive functions and fetal development, the content of DBP must be controlled in food and the environment. The present study aims to develop a sensitive, fast and simple fluorescence polarization immunoassay (FPIA) using monoclonal antibodies derived against DBP (MAb-DBP) for its detection in open waters. New conjugates of DBP with various fluorescein derivatives were obtained and characterized: 5-aminomethylfluorescein (AMF) and dichlorotriazinylaminofluorescein (DTAF). The advantages of using the DBP-AMF conjugate in the FPIA method are shown, the kinetics of binding of this chemical with antibodies are studied, the analysis is optimized, and the concentration of monoclonal antibodies is selected for sensitivity analysis—16 nM. The calibration dependence of the fluorescence polarization signal for the detection of DBP was obtained. The observed IC50 (DBP concentration at which a 50% decrease in the fluorescence polarization signal occurs, 40 ng/mL) and the limit of detection (LOD, 7.5 ng/mL) values were improved by a factor of 45 over the previously described FPIA using polyclonal antibodies. This technique was tested by the recovery method, and the high percentage of DBP discovery in water ranged from 85 to 110%. Using the developed method, real water samples from Lake Onega were tested, and a good correlation was shown between the results of the determination of DBP by the FPIA method and GC-MS. Thus, the FPIA method developed in this work can be used to determine DBP in open-water reservoirs.

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Risk of Phthalate Exposure among Hospitalized Patient via Intravenous Fluids Receiving

Abstract: Background: Phthalates are widely used as plasticizers in polyethylene terephthalate (PET)

Cited by 3 publications

References 19 publications

Leaching of Phthalates from Medical Supplies and Their Implications for Exposure

Leaching of Phthalates from Medical Supplies and Their Implications for Exposure

Adsorption and Leachable Contamination of Flucloxacillin, Cyclosporin and Amiodarone Following Delivery Through an Intravenous Administration Set

Detection of Dibutyl Phthalate in Surface Water by Fluorescence Polarization Immunoassay

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