Risk of stillbirth in us patients with diagnosed intrahepatic cholestasis of pregnancy

Estin, Miriam; Watkins, Virginia Y.; Dotters‐Katz, Sarah K.; Campbell, Alexa; Brady, Carla W.; Federspiel, Jerome J.

doi:10.1016/j.ajog.2022.11.929

Cited by 2 publications

(3 citation statements)

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“…Although there are no systematic review and meta-analysis studies on the incidence of ICP in the literature, limited studies have reported that the incidence of ICP varies between 0.2% and 6.1%. 1,2,[5][6][7][8][9][10][11] In our systematic review and metaanalysis, the incidence of ICP was 1.7%. Studies have found that the incidence of ICP varies according to ethnicity and geographical location.…”

Section: Incidence Of Icpmentioning

confidence: 99%

“…In the literature, the occurrence of ICP in pregnancy ranges from 0.2% to 6.1%, showing significant variations based on ethnicity and geographical location. [1][2][3][5][6][7][8][9][10][11] The incidence of ICP was reported as 0.8% in the United States, 7 3.1% in Pakistan, 8 6.1% in China, 9 and between 0.5 and 0.9% in Turkey. 10,11 The disease process of ICP has not been well understood, and its etiology is affected by a set of genetic, endocrine, and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, the incidence of ICP varies depending on the ethnic composition of the population and diagnostic criteria. In the literature, the occurrence of ICP in pregnancy ranges from 0.2% to 6.1%, showing significant variations based on ethnicity and geographical location 1–3,5–11 . The incidence of ICP was reported as 0.8% in the United States, 7 3.1% in Pakistan, 8 6.1% in China, 9 and between 0.5 and 0.9% in Turkey 10,11 …”

Section: Introductionmentioning

confidence: 99%

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The Incidence of Intrahepatic Cholestasis of Pregnancy and its Maternal, Fetal, and Neonatal Adverse Outcomes: A Systematic Review and Meta‐Analysis

Odabaş,

Sökmen,

Dünder

et al. 2024

J Midwife Womens Health

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IntroductionIntrahepatic cholestasis of pregnancy (ICP) is a problem with an increasing incidence and negative maternal, fetal, and neonatal consequences. This problem is becoming increasingly important. This systematic review and meta‐analysis aimed to determine the incidence of ICP and its adverse maternal, fetal, and neonatal adverse outcomes based on primary research studies.MethodsThis systematic review and meta‐analysis used Preferred Reporting Items for Systematic Reviews and Meta‐Analyses reporting guidelines and was conducted between June and September 2023 using the following keywords: obstetric cholestasis OR intrahepatic cholestasis AND pregnancy OR pregnant OR prenatal OR antenatal OR perinatal OR maternal OR fetal OR neonatal. Quality assessment of the studies was performed using the Critical Appraisal Checklists developed by the JBI Institute. Data were synthesized using meta‐analysis methods.ResultsThe analysis included 10 studies published between 2013 and 2023. The meta‐analysis showed that the incidence of ICP was 1.7% (odds ratio [OR], 0.021; 95% CI, 0.012‐0.027), whereas maternal, fetal, and neonatal adverse outcomes included cesarean birth (OR, 2.938; 95% CI, 1.467‐5.881), preterm birth or preterm prelabor rupture of membranes (OR, 4.241; 95% CI, 1.996‐9.009), hypertensive disorders of pregnancy (OR, 3.715; 95% CI, 1.545‐8.929), maternal infection (OR, 3.301; 95% CI, 2.917‐3.737), neonatal intensive care unit admission (OR, 2.715; 95% CI, 1.458‐5.056), birth weight less than or equal to 2500 g (OR, 2.518; 95% CI, 1.296‐4.892), and small for gestational age (OR, 1.915; 95% CI, 1.424‐2.573).DiscussionThis systematic review and meta‐analysis revealed that ICP has a high incidence and several maternal, fetal, and neonatal adverse outcomes. Therefore, midwives and other health professionals must be aware of these outcomes and provide appropriate care to pregnant individuals with ICP.

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