Risk of venous thromboembolism associated with the insertion/deletion polymorphism in the angiotensin-converting enzyme gene

Ordóñez, Ángel; Carreira, José Manuel Fernández; Rodrı́guez, Julián; Sánchez, Leoncio Martín; Diaz, Ramón; M, Martínez Verduch; Garcı́a, E.Coto

doi:10.1097/00001721-200007000-00011

Cited by 26 publications

(13 citation statements)

References 25 publications

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“…Moreover, no correlation between ACE genotypes and venous thrombosis was found by González Ordóñez et al . [14] These findings disagree with the study concerning with ACE polymorphism by Dilley et al . who studied African-Americans with venous thrombosis and reported a moderate increase of venous thrombosis risk in male patients with the D/D genotype.…”

Section: Discussioncontrasting

confidence: 70%

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Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia

Mahjoub

Abdelrhman

El-Deen

et al. 2016

Int J App Basic Med Res

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Context:Sickle cell anemia (SCA) is a group of hemoglobin disorders in which the sickle β-globin gene is inherited. It is associated with many complications; most of them are related to thrombotic events.Aim:This study aimed to investigate the association between angiotensin converting enzyme (ACE) insertion/deletion polymorphism and complications of SCA.Settings and Design:A case–control study was conducted in Khartoum state.Subjects and Methods:A total of 50 patients with SCA and 40 healthy volunteers as a control group were enrolled in this study. Three milliliters of ethylenediamine tetraacetic acid anticoagulated blood were collected from each subject, DNA was extracted by salting-out method, and target DNA regions of the ACE gene were amplified using allele-specific polymerase chain reaction.Statistical Analysis Used:Data of this study was analyzed by Statistical Package for Social Sciences. Frequency of qualitative variables was calculated, and correlation was tested by Chi-square test. Regression was used to investigate the association between the polymorphism and complications of SCA.Results:The frequencies of the DD, ID, and II genotypes were 42%, 50%, and 8%, respectively, for patients, whereas in the control group, it was 80% for DD genotype and 20% for ID, while II genotype was totally absent. The regression analysis showed no statistically significant association between the disease complications and each of the ACE polymorphic genotypes.Conclusion:No statistically significant association was found between ACE polymorphism and complications of SCA.

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Section: Discussioncontrasting

confidence: 70%

“…[10] It has also been emphasized that the ACE I/D gene polymorphism might be an independent risk factor for thrombotic diseases. [121314]…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia

Mahjoub

Abdelrhman

El-Deen

et al. 2016

Int J App Basic Med Res

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“…However, the finding of the present study is in contrast to the results of other studies. [27][28][29]. In light of these investigations and a metaanalysis study [13] the ACE I/D polymorphism may not be involved in the pathogenesis of DVT.…”

Section: Discussionmentioning

confidence: 92%

Genetic susceptibility to deep venous thromboembolism

Bargahi

Ghorbian

Zonouzi

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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Recently much attention has been paid to the possibly considerable role of the thrombophilic gene polymorphisms in the pathogenesis of deep venous thromboembolism (DVT). However, the reported results are controversial. Hence, this study aimed to disclose the association between factor VII (FVII) 10976G/A, angiotensin-converting enzyme (ACE; intron 16 I/D), glycoprotein Ia (GPIa) 807C/T, tissue-type plasminogen activator (t-PA; intron 8 D/I) and tissue-factor pathway inhibitor 536C/T polymorphisms and DVT. We investigated these gene polymorphisms in 693 study participants including 193 patients who showed clinical symptoms of DVT and 500 healthy individuals without both personal and family histories of thromboembolic disorders. Genotyping was performed using the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique. Comparison of genotypes distribution revealed that the FVII 10976G/A polymorphism was significantly related with DVT (P < 0.05), whereas there was no association between the ACE (intron 16 I/D), GPIa807C/T, t-PA (intron 8 D/I) and tissue-factor pathway inhibitor 536C/T gene polymorphisms and DVT (P > 0.05). In addition, the prevalence of homozygote genotype and mutant allele for FVII 10976G/A polymorphism was significantly higher in cases compared with controls (P < 0.05). Taken together, our data provide evidence to support the hypothesis that FVII 10976G/A polymorphism may be associated with a predisposition to DVT.

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“…Previous studies have shown that the plasma level of angiotensin II is closely associated with ACE gene polymorphisms. ACE I/D gene polymorphism has been described as an independent risk factor for thrombotic diseases as well [8-10]. …”

Section: Discussionmentioning

confidence: 99%

“…It has also been emphasized that the ACE I/D gene polymorphism might be an independent risk factor for thrombotic diseases [8-10]. …”

Section: Introductionmentioning

confidence: 99%

Relationship between angiotensin I-converting enzyme insertion/deletion gene polymorphism and retinal vein occlusion

et al. 2014

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To evaluate the association between angiotensin I-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and retinal vein occlusion (RVO). A total of 80 patients with retinal vein occlusion who was admitted to the Eye Department of Kartal Training and Research Hospital between 2008 and 2011, and 80 subjects were enrolled in this retrospective case–control study. Patients who experienced RVO within one week to six months of study enrolment were included, and those with coronary artery diseases, prior myocardial infarction history and coagulation disturbances were excluded from the study. The diagnosis was made by ophthalmoscopic fundus examination and fluorescein angiography. The ACE gene I/D polymorphism was determined by polymerase chain reaction, and the ACE gene was classified into three types: I/I, I/D and D/D. In multivariate logistic regression analysis, ACE D/D genotype (p = 0.035), diabetes-mellitus (p = 0.019) and hypertension (p = 0.001) were found to be independent predictive factors for RVO. The results of the present study reveal that ACE D/D polymorphism is an independent predictive factor for RVO. However, one cannot definitely conclude that ACE gene polymorphism is a risk factor for retinal vein occlusion.

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Risk of venous thromboembolism associated with the insertion/deletion polymorphism in the angiotensin-converting enzyme gene

Cited by 26 publications

References 25 publications

Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia

Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with vasoocclusive complications of sickle cell anemia

Genetic susceptibility to deep venous thromboembolism

Relationship between angiotensin I-converting enzyme insertion/deletion gene polymorphism and retinal vein occlusion

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