Risk prediction—Homocysteine in Coronary Heart Disease

R, Harish; Govindaraju, Vasanthi; Manjunath, Cholenahalli Nanjappa

doi:10.1007/bf02912875

Cited by 10 publications

(11 citation statements)

References 20 publications

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“…It also turned out to be the one with the highest specificity and accuracy among all the risk factors compared. The results were consistent with other studies [15,16]. However, the levels of folate and other vitamins were not included in the study; it can, therefore, be a limitation in concluding the hypothesis.…”

Section: Discussionsupporting

confidence: 91%

Study of Risk Factors of Coronary Artery Disease with Special Reference to Homocysteine

Sreenija¹,

Sambu²,

Kedam³

et al. 2019

SIJB

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Background: Risk factor reduction is the primary clinical approach in preventing coronary artery disease. Traditional risk factors are found to be absent in many of the cases. Novel risk factorhyper homocysteinemia was reported to be associated with the disease process. Objectives: This study is aimed at identifying the association of coronary artery disease with homocysteine and other conventional risk factors, along with the risk they pose both independently and in combination. Methods: The study included 100 people, 60 subjects in the study group with diagnosed coronary artery disease & 40 subjects in the control group with no disease. Conventional risk factors are evaluated & compared along with homocysteine levels. Results: The data obtained concludes that the levels of homocysteine independently are significantly higher (20.19 ± 5.00) among the study than the control group (12.35 ± 3.39).However, there was no significant association between conventional risk factors homocysteine levels and conventional risk factors (smoking, family history of coronary artery disease, hypertension and diabetes). Conclusion: Elevated levels of homocysteine are associated with coronary artery disease. Homocysteine, in combination with the conventional risk factors, did not pose any increased risk for the disease. Raised levels of Homocysteine in the controls is probably attributed to the early sign of disease occurrence, further investigation is required into this aspect. Also, an investigation is necessary to search for the ways of reduction of risk like vitamin supplementation.

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Section: Discussionsupporting

confidence: 91%

Study of Risk Factors of Coronary Artery Disease with Special Reference to Homocysteine

Sreenija¹,

Sambu²,

Kedam³

et al. 2019

SIJB

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show abstract

“…To determine the linkage between homocysteine and atherosclerosis, various theories has been established, ideas like Growth stimulation of smooth muscles, reduced growth of the endothelial cells, loosening of endothelial cells and dropping in the High DL production [10; 6]. Our data results are in a accordance with previous works done by many researchers from different countries showing a significant raised total serum homocysteine level in ischemic heart disease (unstable angina) [16][17][18][19][20][21][22] .It might be due to deficiency of vitamins B6, B12 and folic acid deficiency. Previous works also explained that homocysteine compound undergoes metabolism by transsulfuration and remethylation pathway.…”

Section: Serum Mda Levels Of the Study Populationsupporting

confidence: 90%

Investigation of Malondialdehyde (MDA), Homocysteine (Hcy) and C- reactive protein (CRP) in sera of patients with Angina Pectoris

Abduljabbar

Ismail

2019

MJS

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Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD Oxidative stress and free radicals are known to have important roles in the development ofAngina Pectoris. Oxidative stress is present in cardiovascular diseases (CVDs), and hyperhomocysteinemia, an independent risk factor for these diseases, may play a role in inducing production of oxygen free radicals. The aim of this study was to determine a possible relationship between blood serum Hcy levels and lipid peroxidation in patients suffering from Angina Pectoris (AP).To evaluate the possible role of homocysteine (Hcy) in inducing oxidative stress in Angina Pectoris(AP), plasma homocysteine( Hcy), plasma malondialdehyde (MDA) and C reactive protein (CRP) were measured in 60 unstable Angina Pectoris patients, we tested 30 healthy volunteers. Hcy was measured by an enzymatic colorimetric method and MDA, an index of lipid peroxidation, by spectrophotometer. Serum Hcy levels were significantly higher in angina pectories (AP) patients than the controls (23.2±8.0 vs 10.76 ± 2.55 micromol/L; P

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“…Twenty CVD conditions (71.4%) of the twenty four studies found that plasma tHcy levels can be employed as a biomarker for the risk of CVD [22,24,25,29,42,43,46,48,[52][53][54][55][56][57][58][59].…”

Section: Resultsmentioning

confidence: 99%

Plasma Total Homocysteine and its Relationship with Cardiovascular Disease

Tsiami¹

2013

J. Nutr. Ther.

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Aims: The specific aim of this review was to compile the first systematic review of systematic reviews and meta-analyses from a range of studies that evaluates the evidence that elevated homocysteine may be a risk factor for CVD. Data Synthesis: 379 entries were identified by initial screening using set criteria revealing eleven meta-analyses, one systematic review, two systematic reviews/meta-analyses and ten other studies, between 1994 and 2013.These studies compared homocysteine levels and its relationship with twelve different types of CVD chronic conditions. Final methodological quality assessment was conducted independently using the instrument AMSTAR for the systematic reviews and meta-analyses. The remaining studies were assessed using data extraction tools from JBI QARI, Appendix 2 & 4 packages. Conclusions: From the selected studies, 82.8% of the CVD conditions demonstrated that epidemiologic and clinical data strongly indicated that elevated homocysteine levels is a risk factor for primary CVD. 71.4% of the CVD conditions demonstrated that plasma tHcy can be employed as an independent biomarker. Despite 46.2% of the CVD conditions finding that reducing plasma tHcy lowers the risk of many CVD events, it remains unclear whether the reduction in plasma tHcy will reduce the risk of some CVD events; it is therefore considered prudent to take precautionary measures to aim for normal levels of homocysteine to avoid the risk of developing or exacerbating CVD. Moreover, it was shown that levels of homocysteine can be profoundly affected by diet, supplementation and lifestyle. The present study will help to clarify the present scientific understanding of this subject.

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Risk prediction—Homocysteine in Coronary Heart Disease

Abstract: Majority of patients who experience a Coronary

Cited by 10 publications

References 20 publications

Study of Risk Factors of Coronary Artery Disease with Special Reference to Homocysteine

Study of Risk Factors of Coronary Artery Disease with Special Reference to Homocysteine

Investigation of Malondialdehyde (MDA), Homocysteine (Hcy) and C- reactive protein (CRP) in sera of patients with Angina Pectoris

Plasma Total Homocysteine and its Relationship with Cardiovascular Disease

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