Risk-Prone Individuals Prefer the Wrong Options on a Rat Version of the Iowa Gambling Task

Rivalan, Marion; Ahmed, Serge H.; Dellu-Hagedorn, Françoise

doi:10.1016/j.biopsych.2009.04.008

Cited by 125 publications

(191 citation statements)

References 29 publications

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“…By contrast, administration of the D 1 receptor antagonist, SCH23390, produced no significant changes in any dependent measures of our loss-chasing task. These data extend recent evidence that aspects of human gambling behaviors can be successfully modeled in rats and pigeons (Rivalan et al, 2009;Scarf et al, 2011;Winstanley et al, 2011;Zeeb et al, 2009). Before discussing the implications of our findings, we first consider aspects of our experiment that are relevant to interpretation.…”

Section: Discussionsupporting

confidence: 78%

Systemic Administration of 8-OH-DPAT and Eticlopride, but not SCH23390, Alters Loss-Chasing Behavior in the Rat

Rogers

Wong

McKinnon

et al. 2013

Neuropsychopharmacol

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Gambling to recover losses is a common gaming behavior. In a clinical context, however, this phenomenon mediates the relationship between diminished control over gambling and the adverse socioeconomic consequences of gambling problems. Modeling loss-chasing through analogous behaviors in rats could facilitate its pharmacological investigation as a potential therapeutic target. Here, rats were trained to make operant responses that produced both food rewards, and unpredictably, imminent time-out periods in which rewards would be unavailable. At these decision points, rats were offered choices between waiting for these time-out periods to elapse before resuming responding for rewards ('quit' responses), or selecting risky options with a 0.5 probability of avoiding the time-outs altogether and a 0.5 probability of time-out periods twice as long as signaled originally ('chase' responses). Chasing behavior, and the latencies to chase or quit, during sequences of unfavorable outcomes were tested following systemic administration of the 5-HT 1A receptor agonist, 8-OH-DPAT, the D 2 receptor antagonist, eticlopride, and the D 1 receptor antagonist, SCH23390. 8-OH-DPAT and eticlopride significantly reduced the proportion of chase responses, and the mean number of consecutive chase responses, in a dose-dependent manner. 8-OH-DPAT also increased latencies to chase. Increasing doses of eticlopride first speeded, then slowed, latencies to quit while SCH23390 had no significant effects on any measure. Research is needed to identify the precise cognitive mechanisms mediating these kinds of risky choices in rats. However, our data provide the first experimental demonstration that 5-HT 1A and D 2 , but not D 1 , receptor activity influence a behavioral analog of loss-chasing in rats.

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Section: Discussionsupporting

confidence: 78%

Systemic Administration of 8-OH-DPAT and Eticlopride, but not SCH23390, Alters Loss-Chasing Behavior in the Rat

Rogers

Wong

McKinnon

et al. 2013

Neuropsychopharmacol

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“…Consistent with the original rat task, two options delivered large rewards or long time-out penalties (disadvantageous), whereas the other two options delivered smaller rewards or shorter time-out penalties (advantageous). The reward and punishment probabilities used here were consistent with those of Rivalan et al (2009). The high punishment durations used here for mice were lower, however, 66 and 132 s compared with 222 and 444 s because of the punishment sensitivity observed in mice.…”

Section: Mouse Igtsupporting

confidence: 74%

“…A single-session IGT was developed for mice based on the original task designed by Rivalan et al (2009). Sixteen five-hole operant chambers were used for the IGT (Supplementary Methods) to provide four illuminated options consistent with the task in rats.…”

Section: Mouse Igtmentioning

confidence: 99%

“…The high punishment durations used here for mice were lower, however, 66 and 132 s compared with 222 and 444 s because of the punishment sensitivity observed in mice. Even with this reduced duration, advantageous choices correlated most strongly with avoiding punishment as opposed to gaining rewards (Supplementary Figure 8), unlike rats (Rivalan et al, 2009). Decision making was measured as %advantageous choices and several other measures were recorded and presented ( Table 2).…”

Section: Mouse Igtmentioning

confidence: 99%

“…Orbitofrontal cortical lesions exaggerated deficits of rats in within-session but not learned (Zeeb and Winstanley, 2011) rat decision-making in single-vs multiple session IGTs, respectively. In the single-session rodent IGT, good, intermediate, and poor decision-making rodents can be identified based on their risk-learning performance (Rivalan et al, 2009). Interindividual differences are also observed among healthy humans performing the IGT (Bechara and Damasio, 2002a;Weller et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reduced Dopamine Transporter Functioning Induces High-Reward Risk-Preference Consistent with Bipolar Disorder

Enkhuizen

Henry

Minassian

et al. 2014

Neuropsychopharmacol

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Individuals with bipolar disorder (BD) exhibit deleterious decision making, negatively impacting their lives. Such aberrant decision making can be quantified using the Iowa Gambling Task (IGT), which requires choosing between advantageous and disadvantageous options based on different reward/punishment schedules. The mechanisms underlying this behavioral deficit are unknown, but may include the reduced dopamine transporter (DAT) functioning reported in BD patients. Using both human and mouse IGTs, we tested whether reduced DAT functioning would recreate patterns of deficient decision making of BD patients. We assessed the IGT performance of 16 BD subjects (7 female) and 17 healthy control (HC) subjects (12 female). We recorded standard IGT performance measures and novel post-reward and post-punishment decision-making strategies. We characterized a novel single-session mouse IGT using C57BL/6J mice (n ¼ 44). The BD and HC IGT performances were compared with the effects of chronic (genetic knockdown (KD; n ¼ 31) and wild-type (n ¼ 28) mice) and acute (C57BL/6J mice (n ¼ 89) treated with the DAT inhibitor GBR12909) reductions of DAT functioning in mice performing this novel IGT. BD patients exhibited impaired decision making compared with HC subjects. Both the good-performing DAT KD and GBR12909-treated mice exhibited poor decision making in the mouse IGT. The deficit of each population was driven by highreward sensitivity. The single-session mouse IGT measures dynamic risk-based decision making similar to humans. Chronic and acute reductions of DAT functioning in mice impaired decision-making consistent with poor IGT performance of BD patients. Hyperdopaminergia caused by reduced DAT may impact poor decision making in BD patients, which should be confirmed in future studies.

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Trigeminal neuropathy causes hypomyelination in the anterior cingulate cortex, disrupts the synchrony of neural circuitry, and impairs decision‐making in male rats

Murugappan

Hasan

Lei

et al. 2021

J of Neuroscience Research

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Risk-Prone Individuals Prefer the Wrong Options on a Rat Version of the Iowa Gambling Task

Cited by 125 publications

References 29 publications

Systemic Administration of 8-OH-DPAT and Eticlopride, but not SCH23390, Alters Loss-Chasing Behavior in the Rat

Systemic Administration of 8-OH-DPAT and Eticlopride, but not SCH23390, Alters Loss-Chasing Behavior in the Rat

Reduced Dopamine Transporter Functioning Induces High-Reward Risk-Preference Consistent with Bipolar Disorder

Trigeminal neuropathy causes hypomyelination in the anterior cingulate cortex, disrupts the synchrony of neural circuitry, and impairs decision‐making in male rats

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