Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers

Hagen, Anne Irene; Mæhle, Lovise; Vedå, Nina; Høberg-Vetti, Hildegunn; Stormorken, Astrid; Ludvigsen, Trond; Guntvedt, Bente; Isern, A E; Schlichting, Ellen; Kleppe, Geir; Bofin, Anna M.; Gullestad, Hans Petter; Møller, Pål

doi:10.1016/j.breast.2013.10.002

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Full text was obtained for 96 studies. Out of these 96 studies, an additional 74 were excluded and 22 met our inclusion criteria as defined above [12-33]. The reasons for exclusion were: 29/74 studies did not evaluate HRQOL, 18/74 were reviews or discussion or editorials, 14/74 were meeting abstracts, 3/74 were published in a foreign language and 10/74 were qualitative studies (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…1). Four studies were designed as prospective cohort studies [15,23,28,31], and rest were case series [12-14,16-22,24-27,29,30,32,33]. Three studies by Metcalfe et al [16,17,19], two studies by Brandberg et al [23,28], two studies by Gahm et al [21,25] and another three studies by Gahm et al [26,27,32] were each based on same patient populations.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies by Metcalfe et al [16,17,19], two studies by Brandberg et al [23,28], two studies by Gahm et al [21,25] and another three studies by Gahm et al [26,27,32] were each based on same patient populations. Eight studies were from Sweden [21,23-28,32], 5 from the US [12-14,20,22], 3 each from Canada [16,17,19] and the Netherlands [18,30,31], and 1 each from UK [15], Turkey [29] and Norway [33]. Four studies compared HRQOL in patients with and without breast reconstruction following BPM [12,14,16,30].…”

Section: Resultsmentioning

confidence: 99%

“…Four studies specifically evaluated patient satisfaction with the decision to have BPM using ad hoc instruments and reported that 84–100% women were satisfied with their decision to undergo BPM [12,16,20,33]. …”

Section: Resultsmentioning

confidence: 99%

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Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes

Razdan¹,

Patel

Jewell

et al. 2015

Qual Life Res

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Purpose Bilateral prophylactic mastectomy (BPM) is effective in reducing the risk of breast cancer in women with a well-defined family history of breast cancer or in women with BRCA 1 or 2 mutations. Evaluating patient-reported outcomes following BPM are thus essential for evaluating success of BPM from patient’s perspective. Our systematic review aimed to: (1) identify studies describing health-related quality of life (HRQOL) in patients following BPM with or without reconstruction; (2) assess the effect of BPM with or without reconstruction on HRQOL; and, (3) identify predictors of HRQOL post BPM. Methods We performed a systematic review of literature using the PRISMA guidelines. PubMed, Embase, PsycINFO, Web of Science, Scopus and Cochrane databases were searched. Results The initial search resulted in 1082 studies; 22 of these studies fulfilled our inclusion criteria. Post BPM, patients are satisfied with the outcomes and report high psychosocial well-being and positive body image. Sexual well-being and somatosensory function are most negatively affected. Vulnerability, psychological distress and preoperative cancer distress are significant negative predictors of quality of life and body image post BPM. Conclusion There is a paucity of high quality data on outcomes of different HRQOL domains post BPM. Future studies should strive to use validated and breast-specific PRO instruments for measuring HRQOL. This will facilitate shared decision-making by enabling surgeons to provide evidence-based answers to women contemplating BPM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes

Razdan¹,

Patel

Jewell

et al. 2015

Qual Life Res

View full text Add to dashboard Cite

show abstract

“…BRCA1/2 mutations are the most frequent of these [64], with substantial variation in the prevalence of each mutation across municipalities in Norway [65]. Norwegian women who carry BRCA1 mutations have a 60% cumulative risk of developing breast cancer [66] and a similar risk of developing ovarian cancer [67]. Most women with identified mutations choose to have their ovaries removed before age 40 years, whereas preventive mastectomy has been less frequent [64], but increasingly used during the last decade [68].…”

Section: Breast Cancer Screening For Women With Familial Breast Cancementioning

confidence: 99%

Bidrar overdiagnostikk til høye melanomtall?

Kristiansen¹,

Bugge²,

Førde³

2018

Tidsskriftet

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Risk-Reducing Mastectomy

Jatoi

Kemp

2021

JAMA

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Mastectomy rates have significantly increased over the last decades, likely due to the rising trend of risk-reducing mastectomies in the treatment and prevention of breast cancer. Growing evidence suggests that aggressive risk-reducing surgical strategies are only justified in high-risk breast cancer situations. Notably, in this selected cohort of women, prophylactic mastectomies offer evident benefit for local and contralateral disease control, and may also provide a survival benefit. Nevertheless, the extent of the increasing frequency of this operation is not explained by the broadening of the medical indications alone. Here we analyze the current evidence regarding riskreducing mastectomies, its clinical practice, and possible explanations for the rising phenomenon of aggressive surgical locoregional control strategies.

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Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers

Cited by 16 publications

References 27 publications

Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes

Quality of life among patients after bilateral prophylactic mastectomy: a systematic review of patient-reported outcomes

Bidrar overdiagnostikk til høye melanomtall?

Risk-Reducing Mastectomy

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