Risk Stratification for Cardiovascular Events in the Improve-It Trial

The results from IMPROVE-IT revalidated the concept that low-density lipoprotein cholesterol (LDL-C) levels are a clinically relevant treatment goal. This trial also suggested that further decrease of LDL-C levels (53 vs. 70 mg/dl; 1.4 vs. 1.8 mmol/l) was more beneficial in lowering CV events. This "even lower is even better" evidence for LDL-C levels may influence future guidelines and the use of new drugs. Furthermore, these findings make ezetimibe a more realistic option to treat patients with statin intolerance or those who cannot achieve LDL-C targets with statin monotherapy.

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Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options

Şerban

Banach

Mikhailidis

2015

Expert Opinion on Pharmacotherapy

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Physiological assessment of coronary stenosis: a view from the coronary microcirculation

Wijntjens¹,

Lavieren²,

Hoef³

et al. 2015

Interventional Cardiology

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Risk Stratification for Cardiovascular Events in the Improve-It Trial

Cited by 2 publications

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Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options

Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options

Physiological assessment of coronary stenosis: a view from the coronary microcirculation

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