Risk Stratification in Upper Gastrointestinal Bleeding: A Measure of Safety and Efficiency in Emergency Care

Costa-Moreira, Pedro; Macedo, Guilherme

doi:10.1159/000512091

Cited by 2 publications

(1 citation statement)

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“…However, accurate risk stratification has shown immense value in terms of its ability to distinguish high-risk patients needing clinical intervention and hospitalization from lower-risk patients possessing a lower likelihood of developing complications and those who may be safely managed in outpatient settings. 52,53 Previous studies have shown that this could reduce the number of hospital admissions by up to 20%. 32 This study demonstrated that the PillSense System could safely and accurately detect gastrointestinal bleeding across a wide range of blood concentrations.…”

Section: Discussionmentioning

confidence: 99%

Preclinical study of a novel ingestible bleeding sensor for upper gastrointestinal bleeding

2024

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Background/Aims: Upper gastrointestinal bleeding (UGIB) is a life-threatening condition that necessitates early identification and intervention and is associated with substantial morbidity, mortality, and socioeconomic burden. However, several diagnostic challenges remain regarding risk stratification and the optimal timing of endoscopy. The PillSense System is a noninvasive device developed to detect blood in patients with UGIB in real time. This study aimed to assess the safety and performance characteristics of PillSense using a simulated bleeding model.Methods: A preclinical study was performed using an in vivo porcine model (14 animals). Fourteen PillSense capsules were endoscopically placed in the stomach and blood was injected into the stomach to simulate bleeding. The safety and sensitivity of blood detection and pill excretion were also investigated.Results: All the sensors successfully detected the presence or absence of blood. The minimum threshold was 9% blood concentration, with additional detection of increasing concentrations of up to 22.5% blood. All the sensors passed naturally through the gastrointestinal tract.Conclusions: This study demonstrated the ability of the PillSense System sensor to detect UGIB across a wide range of blood concentrations. This ingestible device detects UGIB in real time and has the potential to be an effective tool to supplement the current standard of care. These favorable results will be further investigated in future clinical studies.

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Section: Discussionmentioning

confidence: 99%