Risks and Preventive Strategies for <i>Clostridioides difficile</i> Transmission to Household or Community Contacts during Transition in Healthcare Settings

Asgary, Ramin; Snead, Jessica A; Wahid, Nabeel; Ro, Vicky; Halim, Marina; Stribling, Judy

doi:10.3201/eid2707.200209

Cited by 8 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Romania, epidemiological dynamics exhibit a continuous trend, characterized by the escalating incidence of community-acquired CDI. Understanding the factors contributing to CDI occurrence within communities and social care settings is crucial for implementing effective prevention strategies [52,53]. Moreover, the most important strategy in reducing the incidence of this pathology would be a dynamic assessment of the antibiotic susceptibility rates of the most common pathogens in order to limit exposure to multiple antibiotics; this aspect is particularly important in Romania, where both antibiotics consumption per capita and antimicrobial resistance rates are among the highest from Europe [54][55][56][57][58].…”

Section: Discussionmentioning

confidence: 99%

“Primum, non nocere”: The Epidemiology of Toxigenic Clostridioides difficile Strains in the Antibiotic Era—Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe

Stămăteanu,

Pleşca,

Miftode

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Clostridioides difficile infection (CDI), though identified nearly five decades ago, still remains a major challenge, being associated with significant mortality rates. The strains classified as hypervirulent, notably 027/NAP1/BI, have garnered substantial attention from researchers and clinicians due to their direct correlation with the severity of the disease. Our study aims to elucidate the significance of toxigenic Clostridioides difficile (CD) strains in the clinical and therapeutic aspects of managing patients diagnosed with CDI. We conducted a single-center prospective study, including patients with CDI from north-eastern Romania. We subsequently conducted molecular biology testing to ascertain the prevalence of the presumptive 027/NAP1/BI strain within aforementioned geographic region. The patients were systematically compared and assessed both clinically and biologically, employing standardized and comparative methodologies. The study enrolled fifty patients with CDI admitted between January 2020 and June 2020. Among the investigated patients, 43 (86%) exhibited infection with toxigenic CD strains positive for toxin B genes (tcdB), binary toxin genes (cdtA and cdtB), and deletion 117 in regulatory genes (tcdC), while the remaining 7 (14%) tested negative for binary toxin genes (cdtA and cdtB) and deletion 117 in tcdC. The presence of the presumptive 027/NAP1/BI strains was linked to a higher recurrence rate (35.56%, p = 0.025), cardiovascular comorbidities (65.1% vs. 14.2%, p = 0.016), and vancomycin treatment (55.8% vs. 14.3%, p = 0.049). The findings of our investigation revealed an elevated incidence of colitis attributed to presumptive 027/NAP1/BI. Despite the prevalence of the presumptive 027 strain and its associated heightened inflammation among the patients studied, no significant differences were observed regarding the clinical course or mortality outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

“Primum, non nocere”: The Epidemiology of Toxigenic Clostridioides difficile Strains in the Antibiotic Era—Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe

Stămăteanu,

Pleşca,

Miftode

et al. 2024

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Although clindamycin use has been closely associated with the disease historically and remains a major risk factor, more cases are currently associated with therapy with β-lactam agents because of their common use. 18,19…”

Section: Risk Factorsmentioning

confidence: 99%

Problematik Infeksi Clostridium difficile

Tjampakasari,

Hanayurianingtyas

2023

J Biomedika dan Kesehat

View full text Add to dashboard Cite

Clostridium difficile merupakan bakteri Gram-positif, bersifat anaerob penghasil spora. Faktor virulensi dari bakteri ini adalah toksin yang dihasilkannya, yaitu enterotoksin A (TcdA ) dan sitotoksin B (TcdB). Transmisi terjadi secara fekal oral dengan menelan spora bakteri ini. Clostridium difficile penyebab paling umum dari diare terkait fulminan di rumah sakit dan fasilitas kesehatan lainnya dan menjadi perhatian yang signifikan karena meningkatnya angka morbiditas dan mortalitas serta peningkatan biaya perawatan kesehatan. Pasien lanjut usia atau pasien dengan gangguan sistem imun merupakan pasien dengan risiko tertinggi untuk kasus ini. Clostridiosis menunjukkan spektrum infeksi bervariasi, berkisar dari diare ringan yang sembuh sendiri, diare derajat ringan-sedang, hingga diare serius, pseudomembran colitis dan fulminant colitis yang mengancam jiwa sehingga dapat mengakibatkan kematian. Diagnosis ditegakkan dengan deteksi langsung toksin Clostridium difficile dalam feses. Walaupun terapi empirik telah diketahui sebagaimana vankomisin dan fidaksomisin telah digunakan sebagai antibiotik pilihan, namun identifikasi segera pasien dengan gejala infeksi Clostridium difficile sangat penting karena sebagian besar pasien merespon dengan cepat terhadap terapi antimikroba. Pencegahan paling baik dilakukan dengan penerapan tindakan pengendalian infeksi dan penggunaan agen antimikroba secara tepat. Pendidikan profesional kesehatan mengenai tindakan pencegahan seperti mencuci tangan, memakai sarung tangan, dekontamina

show abstract

Empowering patients to prevent healthcare-associated infections

Donskey

2023

American Journal of Infection Control

View full text Add to dashboard Cite

Risks and Preventive Strategies for Clostridioides difficile Transmission to Household or Community Contacts during Transition in Healthcare Settings

Cited by 8 publications

References 25 publications

“Primum, non nocere”: The Epidemiology of Toxigenic Clostridioides difficile Strains in the Antibiotic Era—Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe

“Primum, non nocere”: The Epidemiology of Toxigenic Clostridioides difficile Strains in the Antibiotic Era—Insights from a Prospective Study at a Regional Infectious Diseases Hospital in Eastern Europe

Problematik Infeksi Clostridium difficile

Empowering patients to prevent healthcare-associated infections

Contact Info

Product

Resources

About