Risks of probable SUDEP among people with convulsive epilepsy in rural West China

Zhang, Wen-wu; Yang, Shuanying; Chen, Tao; Deng, Chao; Liu, Ling; Deng, Ying; He, Jun; Li, You; Zhou, Dong

doi:10.1016/j.seizure.2016.05.002

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…Our analysis supported the importance of several risk factors related to SUDEP. Those present in all our cases were early onset of epilepsy (average, 19.4 years old), poor seizure control, generalized tonic-clonic seizures (GTCS) (0.5-3 per month), poor adherence to treatment, and long-lasting epilepsy (average 16.6 years), in accordance with previous studies [7,[22][23][24][25][26]. The average age at the time of death was 36 years, reinforcing the concept that SUDEP affects mainly young patients [15,27].…”

Section: Discussionsupporting

confidence: 90%

SUDEP in Spain: An Epilepsy Monitoring Unit based case series

Sánchez-Larsen

Fernández-Pérez

Príncipe

et al. 2019

Seizure

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SUDEP is the first cause of mortality related to epilepsy. However, in Spain there are no published cases or series from Epilepsy Monitoring Units that could expose the characteristics of SUDEP in our population. Method: We reviewed all patients treated at our Spanish Epilepsy Reference Centre who died between 2010-2018. SUDEP cases were classified as definite, probable, possible or near-SUDEP. Epilepsy type, demographics and case detection issues were described. Results: From 1250 evaluated patients, 102 died during the study period. Seven patients were diagnosed with SUDEP or near-SUDEP: two definite SUDEP, one definite SUDEP plus, two probable SUDEP and two near-SUDEP. Specific problems for detection and registration of SUDEP inherent to the Spanish healthcare system and the legal framework were defined. Only 43% of cases were known by the referral neurologist. SUDEP incidence was 1.3 per 1000 patient/year, comprising 0.56% of all deaths in our cohort. Two cases were female, the average age was 36 years (18-61). All patients had focal epilepsy and suffered from generalized tonic-clonic seizures. All witnessed cases occurred after a focal to bilateral tonic-clonic seizure. Four cases occurred during sleep and all non-witnessed cases were found in prone position. One case occurred during video-EEG monitoring. Conclusions: Our casuistic represents the first Epilepsy Monitoring Unit based case series of SUDEP conducted in Spain. The incidence in our population agrees with the reported in other countries. However, in our population, SUDEP is probably underdiagnosed due to administrative and legal issues.

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Section: Discussionsupporting

confidence: 90%

SUDEP in Spain: An Epilepsy Monitoring Unit based case series

Sánchez-Larsen

Fernández-Pérez

Príncipe

et al. 2019

Seizure

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“…SUDEP may, kill over 20000 people with epilepsy yearly in China based on the incidence and the huge number of people with epilepsy. Risk factors for probable SUDEP identified were childhood onset of epilepsy, high seizure frequency, and uncontrolled seizures 23 . A whole exome sequencing in samples from incident cases of SUDEP found rare variants in SCN5A, KIF6, and TBX18 genes that support the hypothesis that underlying heart disorder may be a driver of SUDEP risk 24 .…”

Section: Prevalence Incidence and Mortalitymentioning

confidence: 99%

Epilepsy in China: major progress in the past two decades

Ding

Zhou

Sander

et al. 2021

The Lancet Neurology

Self Cite

120

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China has about 10 million people with epilepsy. A vast 'epilepsy treatment gap' in China mainly driven by deficiencies in healthcare delivery and social discrimination resulting from cultural beliefs about epilepsy. The WHO's Global Campaign against Epilepsy Demonstration Project in China, which showed that it was possible to treat epilepsy in primary care, was a significant milestone. The China Association against Epilepsy has been a vital force to stimulate epilepsy interest. Nearly 20 anti-seizure medications are available in China. Non-pharmacological options are available, but they are still unmet needs for epilepsy management. The Chinese epilepsy research portfolio is varied, but areas of concentration and thus, expertise are particularly in epidemiology and clinical research. The challenges remaining for further improvement for delivering care for people with epilepsy in China are primarily related to public health and to reducing inequalities within this vast country.

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“…However, it could be explained by the matching of initial seizure frequencies, which were not covered by those earlier studies. In addition, one of our previous reports [12] with a different design compared the seizure frequency of the SUDEP group, proving tonic-clonic seizures were more frequent in that group than in other epilepsy patients. Other than a general comparison, this study focused on more specific time periods before SUDEP.…”

Section: Discussionmentioning

confidence: 91%

“…In 2014, a community-based study in Cornwall, UK [11], reported a phenomenon where 91% of probable SUDEP patients had increased seizure frequency or seizure deterioration 3-6 months prior to their deaths. Our research team published an article in 2016 on the risk factors for probable SUDEP [12], which concluded that non-seizure-free patients were at an increased risk for SUDEP, especially in the months before their deaths. These results implied that SUDEP patients may have more seizures before their deaths.…”

Section: Introductionmentioning

confidence: 99%