Rituximab‐mediated Raf kinase inhibitor protein induction modulates NF‐<i>κ</i>B in Sjögren syndrome

Sisto, Margherita; Lisi, Sabrina; D’Amore, Simona; Lofrumento, Dario Domenico

doi:10.1111/imm.12288

Cited by 16 publications

(16 citation statements)

References 40 publications

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“…On the other hand, RKIP silencing significantly activated NF-κB signalling and increased expression and release of pro-inflammatory mediators. Interestingly, RKIP expression in salivary gland epithelial cells (SGEC) from pSS patients was reported to be significantly lower than that of healthy SGEC, supporting a role for RKIP in the suppression of NF-κB activation in pSS [52].…”

Section: Rkip and Inflammationmentioning

confidence: 99%

RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer

et al. 2019

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Raf kinase inhibitor protein (RKIP), an important modulator of intracellular signalling pathways, is commonly downregulated in multiple cancers. This reduction, or loss of expression, is correlated not only with the presence of metastasis, contributing to RKIP’s classification as a metastasis suppressor, but also with tumour aggressiveness and poor prognosis. Recent findings suggest a strong involvement of RKIP in the modulation of tumour microenvironment components, particularly by controlling the infiltration of specific immune cells and secretion of pro-metastatic factors. Additionally, RKIP interaction with multiple signalling molecules seems to potentiate its function as a regulator of inflammatory processes, mainly through stimulation of anti- or pro-inflammatory cytokines. Furthermore, RKIP is involved in the modulation of immunotherapeutic drugs response, through diverse mechanisms that sensitize cells to apoptosis. In the present review, we will provide updated information about the role of RKIP as an inflammatory and immune modulator and its potential implications in cancer will be addressed.

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Section: Rkip and Inflammationmentioning

confidence: 99%

RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer

et al. 2019

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“…35 These data suggest a link between the downregulation of NF-kB activity on the one hand, and the inhibition of proinflammatory mediators observed in vivo following RTX treatment on the other.…”

Section: Rituximab In Pss: Biological Effectsmentioning

confidence: 81%

Rituximab in primary Sjögren's syndrome: a ten-year journey

Carubbi

Alunno

Cipriani

et al. 2014

Lupus

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Primary Sjo¨gren's syndrome (pSS) is an autoimmune disorder affecting exocrine glands and characterized in most cases by a rather mild clinical picture. However, a subgroup of pSS patients experience systemic extraglandular involvement leading to a worsening of disease prognosis. Current therapeutic options for the treatment of pSS are mainly empirical, often translated by other autoimmune diseases, and recent systematic reviews have highlighted the lack of evidence-based recommendations for most of the drugs commonly employed in the spectrum of extraglandular involvement. Because of the well-established role of B-lymphocytes in the pathogenesis of pSS, a B-cell targeting therapy may represent a new and intriguing therapeutic approach; in this context, growing evidence suggests that B-cell depletion by rituximab (RTX) is also effective in pSS. Of interest, besides clinical efficacy, RTX also showed biologic effects, consistently affecting the inflammation and the lymphoid organization that occur in target tissue. Moreover, the good results observed in the published trials after RTX treatment in pSS should represent the starting point to develop evidence-based guidelines for the use of biologic therapy in this disease. Lupus (2014) 23, 1337-1349.

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“…9 Similarly, an interaction of RKIP with NF-κB has been suggested to occur in primary Sjögren’s syndrome (pSS), an autoimmune disorder characterized by an epithelial injury surrounded by dense lymphocytic infiltrates. 10 Using the human salivary gland epithelial cells (SGEC) from pSS patients and a co-culture system with pSS lymphocytes, results from this study showed that up-regulation of RKIP decreased NF-kB activity. This up-regulation likely contributed to decreases in a group of inflammatory cytokines (e.g IL-1α/β, IL-13, TNF-α, IFN-γ, etc) and chemokines (CXCL1, CXCL6, CCL2, CCL13, etc).…”

Section: Interactions Of Rkip With the Mitogen Activated Protein mentioning

confidence: 85%

Interactions of RKIP with Inflammatory Signaling Pathways

Zhao

Wenzel

2014

Crit Rev Oncog

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The inflammatory response plays an important role in host defense and maintenance of homeostasis, while imbalances in these responses can also lead to pathologic disease processes. Emerging data show that RKIP interacts with multiple signaling molecules which may potentiate multiple functions during inflammatory processes. This chapter will review the interaction of RKIP with both the MAPK and NF-κB pathways in relation to chronic inflammatory diseases. In these settings, it can both inhibit inflammatory pathways as well contribute to pro-inflammatory signaling, often depending on the interactions with multiple proteins and perhaps lipids. The interactions of RKIP with proteins, phospholipids, fatty acids and their enzymes, thus, could play a substantial role in diseases like asthma and diabetes. Targeting interactions of RKP with these pathways could lead to novel approaches to treatment.

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Rituximab‐mediated Raf kinase inhibitor protein induction modulates NF‐κB in Sjögren syndrome

Cited by 16 publications

References 40 publications

RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer

RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer

Rituximab in primary Sjögren's syndrome: a ten-year journey

Interactions of RKIP with Inflammatory Signaling Pathways

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