Rivaroxaban and Apixaban Anti-Xa Measurements: Impact of Plasma Storage for 7 Days at Room Temperature

Boissier, Elodie; Genebrier, Steve; Lakhal, Karim; Nédélec-Gac, Fabienne; Trossaërt, Marc; Ternisien, Catherine; Gouin‐Thibault, Isabelle

doi:10.1055/s-0038-1661391

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…McGrail et al showed an acceptable stability of rivaroxaban and apixaban‐specific anti‐Xa activities up to 8 h after sampling at RT 7 . According to Boissier et al, these parameters are highly reliable after plasma storage at RT up to 7 days after sampling 37 . Conversely, our findings suggest a weak stability of rivaroxaban and apixaban‐specific anti‐Xa activity after thawing.…”

Section: Resultssupporting

confidence: 50%

“…7 According to Boissier et al, these parameters are highly reliable after plasma storage at RT up to 7 days after sampling. 37 Conversely, our findings suggest a weak stability of rivaroxaban and apixaban-specific anti-Xa activity after thawing. Boissier et al considered that the difference in rivaroxaban and apixaban anti-Xa activities is irrelevant if measurements at day 2 and 7 fall within the pre-defined range of acceptability of 80%-120% of the baseline value.…”

Section: Specific Anticoagulant Activitiesmentioning

confidence: 52%

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Stability of coagulation parameters in plasma samples at room temperature after one freeze/thaw cycle

Gaudard

Boissier

Talon

et al. 2022

Int J Lab Hematology

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In clinical laboratories, the pre-analytical step is crucial for coagulation assays because it can influence the results and consequently clinical decision-making. Pre-analytical variables, such as blood sampling, transportation, processing and storage (with time and temperature as variables), influence the haemostasis results. 1 Many data are available on the stability of coagulation parameters and storage conditions (e.g. room temperature (RT) versus 4°C, stability over time) for fresh plasma and whole blood. For instance, in fresh plasma stored at RT, prothrombin time (PT), clauss fibrinogen, antithrombin (AT), factor (F) II, FV, FVII, FX and D-dimers are stable up to 24 h, but activated partial thromboplastin time (aPTT) only for 8 h. [2][3][4][5][6] The impact of the freezing and storage temperatures (i.e. −84°C versus

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Section: Resultssupporting

confidence: 50%

Section: Specific Anticoagulant Activitiesmentioning

confidence: 52%

Stability of coagulation parameters in plasma samples at room temperature after one freeze/thaw cycle

Gaudard

Boissier

Talon

et al. 2022

Int J Lab Hematology

Self Cite

View full text Add to dashboard Cite

show abstract

“…These results were expected given their excellent stability in plasma up to 7 days under the same conditions. 10 In a single case, we observed a significant variation of anti-Xa activity at 6 hours compared with baseline (rivaroxaban, 36 ng/mL). This may be explained by the proximity of this value to the LLOQ, where the CV is higher than those for other levels.…”

Section: Discussionmentioning

confidence: 73%

“…Acceptable variability at 4 and 6 hours was set at ± 15% compared with baseline, consistent with ICSH recommendations. 8 10 Statistical calculations and figures were produced on Microsoft Excel 2019 (Microsoft, United States). Results are reported as median (IQR, interquartile range) or as 95% confidence interval (IC95).…”

Section: Methodsmentioning

confidence: 99%

Stability of Rivaroxaban and Apixaban Anti-Xa Activities in Whole Blood Samples: A French Bicentric Study

et al. 2023

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“…That said, the measure of anticoagulant effect may still be useful in certain situations where treatment decisions can be influenced (e.g. in determining whether an urgent procedure can be performed safely) or in the identification of treatment adherence or overdose [63]. Although NOACs affect PT, INR and aPTT to varying degrees, these changes do not accurately correlate to their anticoagulant activity, [64] only providing qualitative evidence for the anticoagulant activity.…”

Section: Measuring Noac Effectsmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of oral anticoagulants used in atrial fibrillation

Fawzy

Lip

2019

Expert Opinion on Drug Metabolism & Toxicology

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Introduction:The availability of non-vitamin K antagonist oral anti-coagulants alongside vitamin K antagonists has offered a variety of options for anti-coagulation, but has also necessitated a good understanding of the pharmacological properties of each of these drugs prior to their use, to maximise the therapeutic benefit and minimise patient harm Areas covered: This review article outlines the pharmacokinetic and pharmacodynamic profiles of the currently licensed NOACs and VKAs that are most commonly used in clinical practice, with the aim of demonstrating how variations in these processes contribute to their use in clinical practice. A literature search was conducted on PubMed using keywords and relevant articles published by the 31 st of December 2018 were included. Expert opinion:The effect of a drug is determined by a combination of elements which include patient characteristics and external influences, in addition to its pharmacokinetic and pharmacodynamic properties. A good understanding of this is essential. Despite the wealth of information available, particularly on VKAs, our knowledge on the pharmacology responsible for certain drug effects and inter-individual variations is still limited. Increasing efforts are being made to uncover these and includes focus on pharmacogenomics and drug transporter proteins.

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Rivaroxaban and Apixaban Anti-Xa Measurements: Impact of Plasma Storage for 7 Days at Room Temperature

Cited by 8 publications

References 8 publications

Stability of coagulation parameters in plasma samples at room temperature after one freeze/thaw cycle

Stability of coagulation parameters in plasma samples at room temperature after one freeze/thaw cycle

Stability of Rivaroxaban and Apixaban Anti-Xa Activities in Whole Blood Samples: A French Bicentric Study

Pharmacokinetics and pharmacodynamics of oral anticoagulants used in atrial fibrillation

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