RKKP bioactive glass-ceramic material through an aqueous sol-gel process

Lombardi, Mariangela; Cacciotti, Ilaria; Bianco, Alessandra; Montanaro, Laura

doi:10.1016/j.ceramint.2014.10.064

Cited by 19 publications

(10 citation statements)

References 65 publications

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“…2 reveal a broad band within the 2Theta range of 20-30°, due to the predominant presence of an amorphous phase. These results are in good agreement with those reported elsewhere [26,27]. The A−glasses Fig.…”

Section: Xrd For the Stabilised Glassessupporting

confidence: 93%

The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series

Ben–Arfa

Palamà

Salvado

et al. 2020

Ceramics International

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Section: Xrd For the Stabilised Glassessupporting

confidence: 93%

The role of calcium (source & content) on the in vitro behaviour of sol–gel quaternary glass series

Ben–Arfa

Palamà

Salvado

et al. 2020

Ceramics International

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“…The physicochemical characterisation of the RKKP bulk target material and films on Ti was studied [31, 35]. In this work, the XRD pattern of the synthesized RKKP material (Figure 1) and the EDXRD patterns of the RKKP film and Ti substrate are reported (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis was performed according to details given in [31, 35]. The final glass-ceramics, obtained by sol-gel, had the following composition [13]: SiO 2 [43.68], P 2 O 5 [11.10], CaO [31.30], Na 2 O [4.53], MgO [2.78], CaF 2 [4.92], K 2 O [0.19], La 2 O 3 [0.50], and Ta 2 O 5 [1.00].…”

Section: Methodsmentioning

confidence: 99%

Placenta Derived Mesenchymal Stem Cells Hosted on RKKP Glass-Ceramic: A Tissue Engineering Strategy for Bone Regenerative Medicine Applications

Ledda

Fosca

Bonis

et al. 2016

BioMed Research International

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In tissue engineering protocols, the survival of transplanted stem cells is a limiting factor that could be overcome using a cell delivery matrix able to support cell proliferation and differentiation. With this aim, we studied the cell-friendly and biocompatible behavior of RKKP glass-ceramic coated Titanium (Ti) surface seeded with human amniotic mesenchymal stromal cells (hAMSCs) from placenta. The sol-gel synthesis procedure was used to prepare the RKKP glass-ceramic material, which was then deposited onto the Ti surface by Pulsed Laser Deposition method. The cell metabolic activity and proliferation rate, the cytoskeletal actin organization, and the cell cycle phase distribution in hAMSCs seeded on the RKKP coated Ti surface revealed no significant differences when compared to the cells grown on the treated plastic Petri dish. The health of of hAMSCs was also analysed studying the mRNA expressions of MSC key genes and the osteogenic commitment capability using qRT-PCR analysis which resulted in being unchanged in both substrates. In this study, the combination of the hAMSCs' properties together with the bioactive characteristics of RKKP glass-ceramics was investigated and the results obtained indicate its possible use as a new and interesting cell delivery system for bone tissue engineering and regenerative medicine applications.

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“…These substituted materials can be also seen not only as promising bone substitutes but also as drug delivery systems for the controlled-localized delivery, since the ions released during bone substitute resorption could be considered as drugs for bone disease treatment, being able to stimulate the expression of several osteoblastic cell genes [482,483], to induce angiogenesis in vitro and in vivo [484], and to exercise possible antibacterial [485] and inflammatory [486] actions, as evidenced in the case of ionic dissolution products from 45S5 Bioglass ® (e.g., Si, Ca, P, Na) and from other silicate-based glasses [487][488][489][490][491]. Thus it is very important to properly select both the ion doping amount, taking into account its therapeutic level and its release rate, and the ion kinds.…”

Section: Discussionmentioning

confidence: 99%