RNA aptamers for AMPA receptors

Huang, Zhen; Niu, Li

doi:10.1016/j.neuropharm.2021.108761

Cited by 5 publications

(7 citation statements)

References 134 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The discovery of numerous subtypes of 5-HT receptors and compounds that interact with them has provided a powerful impetus for developing new means of modulating serotonin transmission. They affect the synthesis and release of this mediator and 5-HT receptors in the CNS, showing effects similar to classical anxiolytics [11,12].…”

Section: огляди літератури / Literature Reviewsmentioning

confidence: 99%

“…Perampanel is the first representative of this group of drugs that was introduced into clinical practice. It is used in the combined treatment of refractory epilepsy, idiopathic pain [11,12,13,14,15].…”

Section: Main Partmentioning

confidence: 99%

“…терної форми епілепсії, ідіопатичних болей [11,12,13,14,15]. Метаботропні глутаматні рецептори (mGluRs) є відносно новою біомішенню.…”

Section: огляди літератури / Literature Reviewsunclassified

See 2 more Smart Citations

Significance of the Glutamate System in Neurotic Pathology

Sydorenko¹

2023

VPBM

View full text Add to dashboard Cite

A -Work concept and design, B -Data collection and analysis, C -Responsibility for statistical analysis, D -Writing the article, E -Critical review, F -Final approval of the article / A -концепція роботи та дизайн, В -збір та аналіз даних, С -відповідальність за статичний аналіз, D -написання статті, Е -критичний огляд, F -остаточне затвердження статті.

show abstract

Section: огляди літератури / Literature Reviewsmentioning

confidence: 99%

Section: Main Partmentioning

confidence: 99%

See 1 more Smart Citation

Significance of the Glutamate System in Neurotic Pathology

Sydorenko¹

2023

VPBM

View full text Add to dashboard Cite

show abstract

“…Natural RNA undergoes degradation at the 2′-OH position of the nucleoside, with the half-life (t1/2) of unmodified aptamers typically lasting a few minutes. Chemical modifications aimed at improving RNA stability and that can extend t1/2 up to several days have included the replacement of the 2'-OH group with 2′-fluoro (2′-F), 2′-OCH3 or 2′-NH2 group, capping of the 3′-end, or conjugation with polyethylene glycol (PEG) (Figure 9) [212][213][214][215][216]. [217]).…”

Section: Rna Aptamersmentioning

confidence: 99%

Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective

Chałupnik

Szymańska

2023

IJMS

View full text Add to dashboard Cite

Since the 1990s, ionotropic glutamate receptors have served as an outstanding target for drug discovery research aimed at the discovery of new neurotherapeutic agents. With the recent approval of perampanel, the first marketed non-competitive antagonist of AMPA receptors, particular interest has been directed toward ‘non-NMDA’ (AMPA and kainate) receptor inhibitors. Although the role of AMPA receptors in the development of neurological or psychiatric disorders has been well recognized and characterized, progress in understanding the function of kainate receptors (KARs) has been hampered, mainly due to the lack of specific and selective pharmacological tools. The latest findings in the biology of KA receptors indicate that they are involved in neurophysiological activity and play an important role in both health and disease, including conditions such as anxiety, schizophrenia, epilepsy, neuropathic pain, and migraine. Therefore, we reviewed recent advances in the field of competitive and non-competitive kainate receptor antagonists and their potential therapeutic applications. Due to the high level of structural divergence among the compounds described here, we decided to divide them into seven groups according to their overall structure, presenting a total of 72 active compounds.

show abstract

“…To simplify DNA PCR with consequent transcription for the following round of SELEX, reverse transcription for RNA aptamers must be carried out in each selection round. Compared with DNA aptamers, RNA aptamers generate more varied and complex 3D structures, providing a wider range of conformations [ 70 ].…”

Section: Aptamersmentioning

confidence: 99%

Aptamers Versus Vascular Endothelial Growth Factor (VEGF): A New Battle against Ovarian Cancer

Mishra,

Chattaraj,

Mishra

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Cancer is one of the diseases that causes a high mortality as it involves unregulated and abnormal cell growth proliferation that can manifest in any body region. One of the typical ovarian cancer symptoms is damage to the female reproductive system. The death rate can be reduced through early detection of the ovarian cancer. Promising probes that can detect ovarian cancer are suitable aptamers. Aptamers, i.e., so-called chemical antibodies, have a strong affinity for the target biomarker and can typically be identified starting from a random library of oligonucleotides. Compared with other probes, ovarian cancer targeting using aptamers has demonstrated superior detection effectiveness. Various aptamers have been selected to detect the ovarian tumor biomarker, vascular endothelial growth factor (VEGF). The present review highlights the development of particular aptamers that target VEGF and detect ovarian cancer at its earliest stages. The therapeutic efficacy of aptamers in ovarian cancer treatment is also discussed.

show abstract

RNA aptamers for AMPA receptors

Cited by 5 publications

References 134 publications

Significance of the Glutamate System in Neurotic Pathology

Significance of the Glutamate System in Neurotic Pathology

Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective

Aptamers Versus Vascular Endothelial Growth Factor (VEGF): A New Battle against Ovarian Cancer

Contact Info

Product

Resources

About