Robot-assisted laser tissue soldering system

Basov, Svetlana; Milstein, Amit; Sulimani, Erez; Platkov, Max; Peretz, Eli; Rattunde, M.; Wagner, J.; Netz, Uri; Katzir, Abraham; Nisky, Ilana

doi:10.1364/boe.9.005635

Cited by 18 publications

(13 citation statements)

References 55 publications

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“…We developed a fiber-optic laser soldering system with an improved handpiece, combining two types of optical fibers arranged in a bundle. The bundle included a silica fiber, surrounded by 4 to 6 AgClBr fibers that had been made by the Applied Physics Group at Tel-Aviv University 24,35 and were highly transparent in the mid-IR. The silica fiber transmitted the 1.9-μm laser radiation from the proximal end to the distal end of the bundle to heat a spot of diameter of ≈2 mm on the incision.…”

Section: Beam Delivery and Temperature Controlmentioning

confidence: 99%

“…24,34 Recently, we used robotic laser soldering for bonding incisions in mouse skins in vitro and obtained a high bond strength. 35 Using this technique, we were able to deliver a measured amount of heat for a predefined amount of time, repeatably, thereby obtaining standardization and allowing for remote (e.g., daVinci System) operation or even an unaided one.…”

Section: Introductionmentioning

confidence: 99%

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Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

et al. 2019

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Suturing of corneal incisions requires significant skill. We demonstrate a noncontact method that will simplify the bonding process. 5-mm-long penetrating vertical and slanted incisions were made in corneas of eyes, extracted from dead piglets. A fiber-optic laser system was used for laser soldering of the incisions, under close temperature control, using albumin solder. The burst-pressure P B immediately after the soldering was found to be P B ≈ 92 and 875 mmHg, for vertical and slanted incisions, respectively. P B ¼ 875 mmHg is an exceptionally high figure, ≈10 times the clinically acceptable value for sutured incisions. Laser soldering was then performed on penetrating incisions made in the corneas of live healthy piglets, of weight ≈10 Kg. After a healing period, the eyes were extracted, and the corneas were examined by histopathology and by optical coherence tomography. Our method immediately generated watertight and strong bonding without noticeable corneal shape distortion. These results would be beneficial for cataract surgery and for corneal transplantations. The fiber-optic system makes it much easier to bond corneal incisions. In the future, laser soldering could be automated and efficiently used by less experienced surgeons, thereby reducing the workload on the experienced ones.

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Section: Beam Delivery and Temperature Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

et al. 2019

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“…36 Robot-assisted laser tissue soldering was evaluated by measuring the tearing forces. 37 However, such technologies and features can only detect morphological variations in ablated biological tissues. Optical energy modulation 38 is used to attain a constant interstitial tissue temperature and to induce predetermined thermal coagulation without carbonization in tissue.…”

Section: Introductionmentioning

confidence: 99%

Quantitative investigation of laser ablation based on real‐time temperature variations and OCT images for laser treatment applications

Fan

et al. 2021

Lasers Surg Med

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Background and Objective: Lasers are widely employed in clinical applications. In vivo monitoring of real-time information about different-wavelength laser surgeries would provide important surgical feedback for surgeons or clinical therapy instruments. However, the quantitative effect of laser ablation or vaporization still needs to be further explored and investigated. Here, we investigate and quantitatively evaluate the ablation variations and morphological changes of two laser ablation models: point-and sweeping-based models. Methods: An infrared thermal imager was used to monitor the temperature variations, and curve fitting was used to build the relationship between the laser radiation duration/sweeping speed and quantitative parameters of the ablated areas. Optical coherence tomography (OCT) images were used to visualize the inner structure and evaluate the depth of the ablated craters. Optical attenuation coefficients (OACs) were computed to characterize the normal and ablated tissues.Results: The results demonstrated that there was a good linear relationship between radiation duration and temperature variation. Similarly, a linear relationship was observed between the sweeping speed and quantitative parameters of craters or scratches (width and depth). The mean OAC of normal tissues was significantly distinguished from the mean OACs of the ablated craters or scratches. Conclusion: Laser ablation was investigated based on a quantitative parameter analysis, thermal detection, and OCT imaging, and the results successfully demonstrated that there is a linear relationship between the laser parameters and quantitative parameters of the ablated tissues under the current settings. Such technology could be used to provide quantitative solutions for exploring the lasertissue biological effect and improve the performance of medical image-guided laser ablation in the future.

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“…Thulium fiber lasers (Tm-FL) operating with laser wavelengths between 1.6 to 2.1 μm [ 4 , 21 , 22 , 23 ] were proposed for various applications, including as a biomedical tool for tissue soldering [ 24 ] and lithotripsy [ 25 ], while they are considered as highly efficient lasers for material processing applications, especially for polymer processing [ 26 , 27 ] since the emission bands of Tm-lasers coincide with the absorption bands of the polymers [ 28 ]. In addition, their applications are extended to greenhouse atmospheric gas sensing [ 29 , 30 ], such as the measurement of CO 2 concentration.…”

Section: Introductionmentioning

confidence: 99%

Femtosecond Laser Plane-by-Plane Inscribed Cavity Mirrors for Monolithic Fiber Lasers in Thulium-Doped Fiber

Theodosiou

Aubrecht

Kašík

et al. 2021

Sensors

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A monolithic fiber laser operating in the short wavelength infrared that is suitable for CO2 gas sensing applications is proposed and presented. The current study reports a laser design based on the direct inscription of a monolithic Fabry–Perot (FP) cavity in a thulium-doped optical fiber using the femtosecond laser (FsL) plane-by-plane inscription method to produce the cavity mirrors. The FP cavity was inscribed directly into the active fiber using two wavelength-identical fiber Bragg gratings (FBGs), one with high and one with low reflectivity. Initially the effective length of the fiber was defined using a single high reflectivity FBG and subsequently a very weak FBG was inscribed at the other end of the fiber in order to demonstrate a fully monolithic fiber laser. All fiber lasers were designed for continuous wave operation at 1950 nm and characterized with respect to the power output, slope efficiency, stability, and effective resonator length. The performance of the presented monolithic laser cavities was evaluated using the same active fiber as a reference fiber spliced to FBGs inscribed in passive fiber; an improvement exceeding 12% slope efficiency is reported for the presented monolithic laser.

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Robot-assisted laser tissue soldering system

Cited by 18 publications

References 55 publications

Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

Strong bonding of corneal incisions using a noncontact fiber-optic laser soldering method

Quantitative investigation of laser ablation based on real‐time temperature variations and OCT images for laser treatment applications

Femtosecond Laser Plane-by-Plane Inscribed Cavity Mirrors for Monolithic Fiber Lasers in Thulium-Doped Fiber

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