Robot-assisted subretinal injection system: development and preliminary verification

Yang, Kunkun; Jin, Xin; Wang, Zhaodong; Fang, Y.; Zhao, Li; Yang, Zhe; Cong, Jinju; Yang, Yang; Huang, Y.; Wang, Liqiang

doi:10.1186/s12886-022-02720-4

Cited by 8 publications

(10 citation statements)

References 28 publications

(44 reference statements)

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“…The review included four trials from Belgium, Germany, the UK, and China [ 5 , 12 – 14 ]. One was a randomized controlled trial evaluating RA SI in humans.…”

Section: Resultsmentioning

confidence: 99%

Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review

Łajczak,

Nawrat

2024

J Robotic Surg

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Subretinal injection (SI) is a novel drug delivery method, directly to retina for treatment of various eye disease. However, manual injection requires surgical experience and precision due to physiological factors. Robots offer solution to this issue, by reducing hand tremor and increased accuracy. This systematic review analyzes current status on robot-assisted SI compared to conventional techniques. Systematic search across 5 databases was conducted to identify studies comparing manual and robot-assisted SI procedures. Extracted data included robotic systems, complications, and success rates. Four studies, including one human trial, two ex vivo porcine eye studies, and one artificial eye model study were included in the synthesis. The findings show early advantages of robot-assisted SI. Compared to traditional interventions, robot procedures result in reduced tremor, what potentially lowers the risk of complications, including retinal tears and reflux. The first in-human randomized trial showed encouraging results, with no significant differences in surgical times or complications between robot-assisted and manual SI. However, major limitation of robot-assisted procedures is longer procedure time. Robot-assisted SI holds promise by offering increased precision and stability, reducing human error and potentially improving clinical outcomes. Challenges include cost, availability, and learning curve. Overall, early stage of robot-assisted SI suggests advantages in precision, complication reduction, and potentially improved drug delivery. Further research in human randomized trials is needed to fully assess its full-scale clinical application.

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“…The review included four trials from Belgium, Germany, the UK, and China [ 5 , 12 – 14 ]. One was a randomized controlled trial evaluating RA SI in humans.…”

Section: Resultsmentioning

confidence: 99%

Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review

Łajczak,

Nawrat

2024

J Robotic Surg

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“…This is more important because future advances will allow for digital navigation decisions in a surgical VR realm, and potentially from geographically distant locations. For tele-pre-surgery training, we envision that such a csVR setup can enhance the procedure for robotic-assisted intravitreal injections 30 , 31 , cataract surgery 9 , 32 , or vitreoretional surgery 33 – 35 .…”

Section: Discussionmentioning

confidence: 99%

Validation of collaborative cyberspace virtual reality oculometry enhanced with near real-time spatial audio

Maloca

Zarranz‐Ventura

Valmaggia

et al. 2023

Sci Rep

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Currently, most medical image data, such as optical coherence tomography (OCT) images, are displayed in two dimensions on a computer screen. Advances in computer information technology have contributed to the growing storage of these data in electronic form. However, the data are usually processed only locally on site. To overcome such hurdles, a cyberspace virtual reality (csVR) application was validated, in which interactive OCT data were presented simultaneously to geographically distant sites (Lucerne, London, and Barcelona) where three graders independently measured the ocular csVR OCT diameters. A total of 109 objects were measured, each three times, resulting in a total of 327 csVR measurements. A minor mean absolute difference of 5.3 µm was found among the 3 measurements of an object (standard deviation 4.2 µm, coefficient of variation 0.3% with respect to the mean object size). Despite the 5 h of online work, csVR was well tolerated and safe. Digital high-resolution OCT data can be remotely and collaboratively processed in csVR. With csVR, measurements and actions enhanced with spatial audio communication can be made consistently in near real time, even if the users are situated geographically far apart. The proposed visuo-auditory framework has the potential to further boost the convenience of digital medicine toward csVR precision and collaborative medicine.

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“…The pioneering use of robotic technology in surgery led to the development of more advanced surgical robots like the da Vinci Surgical System, approved in 2000 by the Food and Drug Administration for use in minimally invasive surgeries. 5 In the facial region, the robots have already been in use for intraoral surgery, 6 plastic surgery, 7 ophthalmology, 8 dental procedures, 9 and hair transplant surgery. 10 The ARTAS device was one of the first robotic devices to automatically select/ harvest the follicular unit grafts and perform the motion without human intervention.…”

Section: Brief Historymentioning

confidence: 99%

Role of Robotics in Neuromodulator and Filler Injections of Face

Kapoor,

Bertossi

2023

Indian J Plast Surg

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In recent years, robots have been increasingly used in various fields of medicine, including surgery, dentistry, and ophthalmology. One of the newest and most promising applications of robotic technology in medicine is in the field of facial aesthetics, particularly in the injection of facial fillers and neuromodulators. While facial injections have traditionally been performed manually by trained physicians and nurses, the introduction of robots has the potential to revolutionize the field, offering a range of potential benefits, including increased precision, accuracy, and consistency of results. However, the significant disadvantages of robots are high cost, lack of flexibility and personal touch, limited experience, and risk of injury due to malfunction.

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Robot-assisted subretinal injection system: development and preliminary verification

Cited by 8 publications

References 28 publications

Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review

Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review

Validation of collaborative cyberspace virtual reality oculometry enhanced with near real-time spatial audio

Role of Robotics in Neuromodulator and Filler Injections of Face

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