Robust and magnetically recoverable dual-sensor particles: Real-time monitoring of glucose and dissolved oxygen

Mao, Yongyun; Mei, Zhipeng; Liang, Lanfeng; Zhou, Bingpu; Tian, Yanqing

doi:10.1016/j.snb.2018.02.024

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…In recent years, many materials including carbon materials, noble metals, transition metals and transition metal oxides have been widely investigated and used as the active materials in non-enzymatic glucose sensor 26–28 . The poor biocompatibility and low electrical conductivity of carbon materials and high price of noble metals hinder their practical applications 29–31 .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of porous NiMn2O4 nanosheet arrays on nickel foam as an advanced sensor material for non-enzymatic glucose detection

Zhang

Sun

et al. 2019

Sci Rep

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In this work, porous NiMn2O4 nanosheet arrays on nickel foam (NiMn2O4 NSs@NF) was successfully fabricated by a simple hydrothermal step followed by a heat treatment. Porous NiMn2O4 NSs@NF is directly used as a sensor electrode for electrochemical detecting glucose. The NiMn2O4 nanosheet arrays are uniformly grown and packed on nickel foam to forming sensor electrode. The porous NiMn2O4 NSs@NF electrode not only provides the abundant accessible active sites and the effective ion-transport pathways, but also offers the efficient electron transport pathways for the electrochemical catalytic reaction by the high conductive nickel foam. This synergy effect endows porous NiMn2O4 NSs@NF with excellent electrochemical behaviors for glucose detection. The electrochemical measurements are used to investigate the performances of glucose detection. Porous NiMn2O4 NSs@NF for detecting glucose exhibits the high sensitivity of 12.2 mA mM−1 cm−2 at the window concentrations of 0.99–67.30 μM (correlation coefficient = 0.9982) and 12.3 mA mM−1 cm−2 at the window concentrations of 0.115–0.661 mM (correlation coefficient = 0.9908). In addition, porous NiMn2O4 NSs@NF also exhibits a fast response of 2 s and a low LOD of 0.24 µM. The combination of porous NiMn2O4 nanosheet arrays and nickel foam is a meaningful strategy to fabricate high performance non-enzymatic glucose sensor. These excellent properties reveal its potential application in the clinical detection of glucose.

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Section: Introductionmentioning

confidence: 99%

Fabrication of porous NiMn2O4 nanosheet arrays on nickel foam as an advanced sensor material for non-enzymatic glucose detection

Zhang

Sun

et al. 2019

Sci Rep

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“…The quantum yields of platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) in these micelles depend on whether there is energy transfer in the micelles [28] and the structures of the polymers [29], which are approximately between 0.107 and 0.231. Other research groups have reported the use of conjugated polymers or metalloporphyrins nanoparticles to achieve a high quantum yield of 0.18 for intracellular oxygen sensing [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Oxygen Sensors Based on PtTFPP and Four-Arm Block Copolymers

Qiao

Pan

et al. 2019

Applied Sciences

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Featured Application: Nanosensors for extracellular oxygen-sensing.Abstract: Three four-arm amphiphilic block copolymers with different chain lengths, consisting of a hydrophilic chain of polyethylene glycol (PEG) and hydrophobic segment of polycaprolactam (PCL), were synthesized and used to encapsulate the high-efficient and hydrophobic oxygen probe of platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) to form polymer micelles. This approach enabled the use of PtTFPP in aqueous solution for biosensing. Experimental results demonstrated that the particle sizes of these nano-oxygen sensors between 40.0 and 203.8 nm depend on the structures of block copolymers. PtTFPP in these micelles showed an effective quantum yield under nitrogen environment, ranging from 0.06 to 0.159. The new sensors are suitable for analyzing dissolved oxygen concentrations in the range of 0.04-39.3 mg/L by using the linear Stern-Volmer equation at room temperature. In addition, it has been shown that these sensors are capable of in situ monitoring the dissolved oxygens in the culture medium of E. coli and Romas cells during the respiration process, and distinguishing the drug activity of antibiotic ampicillin from that of antimycin A. This study showed that the use of these nanostructured multi-arm block copolymer micelles can achieve efficient biological applications without specific structural modification of the hydrophobic PtTFPP probe, which is expected to have broad prospects.

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“…All diffraction peaks for Fe according to the references of JCPDS card no. JCPDS 19-0629 [33,[37][38]. The VSM measurements (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Although polyspheres with dissolved oxygen-sensitive probes have been reported in the literature, most of these are prone to agglomeration or precipitation, and have particular di culty in forming a stable dispersion and solution system in water [33,34]. Magnetical nanoparticles (NPs) are increasingly important in many biomedical applications, such as drug delivery, hyperthermia treatment, and magnetic resonance imaging (MRI) contrast enhancement [35,36].…”

Section: Introductionmentioning

confidence: 99%

Magnetically reusable and well-dispersed nanoparticles for oxygen detection in water

Cui

Wang

et al. 2021

Preprint

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In this study, we aimed to synthesize magnetically well-dispersed nanosensors for detecting dissolved oxygen (DO) in water, and explore their biological applications. Firstly, we synthesized two kinds of magnetic nanoparticle with average sizes of approximately 82 nm by one-step emulsion polymerization: polystyrene magnetic nanoparticles (Fe3O4@Os1-PS) and polymethylmethacrylate magnetic nanoparticles (Fe3O4@Os1-PMMA). Both types of nanoparticle present good dispersibility and fluorescence stability. The nanoparticles could be used as oxygen sensors that exhibited a high DO-sensitivity response in the range 0-39.30 mg/L, with a strong linear relationship. The nanoparticles have good magnetic properties, and so they could be recycled by magnet for further use. Recovered Fe3O4@Os1-PS still presented high stability after continued use in oxygen sensing for one month. Furthermore, Fe3O4@Os1-PS was employed for detecting the bacterial oxygen consumption of Escherichia coli (E-coli) to monitor the metabolism of bacteria. The results show that Fe3O4@Os1-PS provide high biocompatibility and non-toxicity. Polystyrene magnetic nanoparticles therefore present significant potential for application in biological oxygen sensing.

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Robust and magnetically recoverable dual-sensor particles: Real-time monitoring of glucose and dissolved oxygen

Cited by 9 publications

References 38 publications

Fabrication of porous NiMn2O4 nanosheet arrays on nickel foam as an advanced sensor material for non-enzymatic glucose detection

Fabrication of porous NiMn2O4 nanosheet arrays on nickel foam as an advanced sensor material for non-enzymatic glucose detection

Extracellular Oxygen Sensors Based on PtTFPP and Four-Arm Block Copolymers

Magnetically reusable and well-dispersed nanoparticles for oxygen detection in water

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