Robust and stimuli‐responsive POSS hybrid PDMAEMA hydrogels for controlled drug release

Abstract

A new polyhedral oligomeric silsesquioxane (POSS) hybrid hydrogels were desinged and fabricated by introducing cationic octa-ammonium (Oa)-POSS) into chemically cross-linked cationic PDMAEMA hydrogels via in situ radical freezing polymerization. The prepared gels (shorten as OP-PD gels) show considerably improved properties through the effective incorporation and dispersion of Oa-POSS particles in gels. Comparing to the Oa-POSS-free gels, the hybrid gels own better mechanical properties with higher tensile and compressive strength. Meantime, except the decreased swelling ratio in acid condition, the OP-PD gels still keep excellent swelling ability with obvious pH and temperature double responsiveness, which is affected by the content of Oa-POSS slightly. All OP-PD gels exhibit an ultrarapid deswelling rate due to the interconnected micropores structure caused by freezing and the formation of microhydrophobic region around POSS particles. Moreover, the application potential of OP-PD gels in drug release was exploited by using flutamide as target drug, the result showed that the increased Oa-POSS could improve the drug loading ability, and OP-PD gels showed well controlled-release effect in simulated human stomachic condition. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2345-2355, 2016.

Synthesis of polyhedral oligomeric silsesquioxane nano‐crosslinked poly(ethylene glycol)‐based hybrid hydrogels for drug delivery and antibacterial activity

“…, the negative nitrate ions of MTZ interact with the positive ammonium ions of OA‐POSS to increase drug loading in G3 hybrid hydrogel. A similar interaction between flutamide and OA‐POSS was reported by Chen et al . Considering all results, the G3 hybrid hydrogel with OA‐POSS as the crosslinker and long PEG chains positively affected MTZ loading in that hybrid hydrogel under acidic condition.…”

“…Due to their unique properties such as high affinity for water, biocompatibility and tissue‐like properties, hydrogels are used widely in biomedical applications for soft tissue regeneration and drug delivery . In the last decade, polyhedral oligomeric silsesquioxanes (POSS), due to their biocompatibility, high structural stability and ease of surface functionalization, have been used to synthesize a broad range of organic–inorganic hybrid hydrogels using a variety of organic functional groups . POSS nanoparticles with a symmetric cubic cage‐like nanostructure can be incorporated in the structure of hydrogels via chemical and physical crosslinking.…”

Enhanced mechanical properties and self‐healing behavior of PNIPAM nanocomposite hydrogel by using POSS as a physical crosslinker

“…Mu et al 44 utilized octa(propylglycidyl ether) polyhedral oligomeric silsesquioxane as a nanocross-linking agent to react with poly(N-isopropylacrylamide) (PNIPAM) to prepare crosslinked PNIPAM hydrogels. Recently, Chen et al 46 first reported a responsive nanocomposite hydrogel (OP-PD gels) by introducing cationic POSS (Oa-POSS) into chemically crosslinked PDMAEMA hydrogels via in situ radical freezing polymerization. In our previous work, we prepared a temperature and pH dual-responsive hybrid hydrogel with octavinyl polyhedral oligomeric silsesquioxane (OVPS) as crosslinker instead of BIS.…”

“…However, nanocomposite hydrogels crosslinked chemically lack some desirable properties such as self-healing that mainly reported in physically crosslinked hydrogels. Recently, Chen et al 46 first reported a responsive nanocomposite hydrogel (OP-PD gels) by introducing cationic POSS (Oa-POSS) into chemically crosslinked PDMAEMA hydrogels via in situ radical freezing polymerization. The resulted gels showed better mechanical properties with higher tensile and compressive strength than Oa-POSS-free gels.…”

In vivo feasibility study of the use of porous polyhedral oligomeric silsesquioxane implants in partial laryngeal reconstruction

“…Porous polyhedral oligomeric silsesquioxane (POSS) are a candidate class of materials with cage-like structures at the molecular level with a surface that can be easily modified in 3 various ways. POSS is widely used in industry, for example in circuit-printing 15 , but has also been modified for biomedical applications, such as copolymers for photodynamic therapy, controlled drug release and osteogenesis [16][17][18][19] . Of this family, POSS-PCU (POSSpolycarbonate-urea) appeared to have important candidate properties, specifically the ability to retain geometry in vivo 20 .…”