The Missing Children Mobile GIS Mutual Assistance System of China (MCMAS) is a mobile service software based on mobile GIS platform software, and it is committed to providing the most convenient and efficient system of personally mutual tracing services for missing children family and society. Relying on collaborative utilization of location-based service technology, face image intelligent recognition technology, cloud computing technology, public big data sharing technology, and mobile GIS technology, the MCMAS has achieved prominent application effects since it was deployed. At present, the MCMAS is running soundly, and it has received and released the information about 1011 missing children from May 25, 2016 to May 25, 2017. In order to explore the geographical distribution features and the influencing factors of missing children, the data of missing children are used for spatial and visual analysis by the data mining and GIS technologies. At the same time, we have built the spatial thermodynamic diagram of the big data of China missing children. By comparing provinces and cities with a higher proportion of missing children, the results showed that: 1) The high proportion of missing children spatially concentrated in the eastern part of the China. 2) The number of missing children was significantly correlated with the population density and economic status of the city. Furthermore, the paper macro-levelly presents a basic basis for rescuing the missing children from two aspects: regionally spatial characteristics and influencing factors.