Robust inference with censored survival data

Abstract

Randomly censored survival data appear in a wide variety of applications in which the time until the occurrence of a certain event is not completely observable.In this paper, we assume that the statistician observes a possibly censored survival time along with a censoring indicator. In this setting, we study a class of M-estimators with a bounded influence function, in the spirit of the infinitesimal approach to robustness. We outline the main asymptotic properties of the robust M-estimators and characterize the optimal B-robust estimator according to two possible measures of sensitivity. Building on these results, we define robust testing procedures which are natural counterparts to the classical Wald, score, and likelihood ratio tests. The empirical performance of our robust estimators and tests is assessed in two extensive simulation studies. An application to data from a well-known medical study on head and neck cancer is also presented.