Based on the multi-level structure attributes of regional logistics, regional logistics integration presents complex features. Therefore, according to the operational requirements of regional logistics integration, we built a regional logistics network structure model consisting of infrastructure, information resources, and organizational networks; selected the level of relationship between different layers and information dissemination, and transport flow as decision variables. We built a supernetwork mathematical model of regional logistics integration with multiple layers of attributes. Considering the constraints of marginal cost changes and overall revenue, we found an equilibrium solution for the operation of regional logistics integration supernetwork. That is, the optimal match between the level of relationship, the level of information dissemination and the transportation flow, provides a reference basis for the formulation of relevant policies and implementation strategies.