Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography

Li, Qingyun; Karnowski, Karol; Noble, Peter B.; Cairncross, Alvenia; James, Alan; Villiger, Martin; Sampson, David D.

doi:10.1364/boe.9.005437

Cited by 52 publications

(45 citation statements)

References 44 publications

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“…An assumption of the study is that perfect information on airway structure is obtainable throughout the airway tree, which is currently impractical. Structural information can be obtained using CT (6), bronchoscopy (32), or OCT (1,22,25), but this is likely to be limited to a relatively small number of relatively large airways. Exactly how much data might be plausibly collected, and how much uncertainty this introduces into the structure-guided predictions, remains an open question.…”

Section: Discussionmentioning

confidence: 99%

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Donovan

Elliot

Boser³

et al. 2019

Journal of Applied Physiology

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Bronchial thermoplasty is a recent treatment for asthma in which ablative thermal energy is delivered to specific large airways according to clinical guidelines. Therefore, current practice is effectively “blind,” as it is not informed by patient-specific data. The present study seeks to establish whether a patient-specific approach based on structural or functional patient data can improve outcomes and/or reduce the number of procedures required for clinical efficacy. We employed a combination of extensive human lung specimens and novel computational methods to predict bronchial thermoplasty outcomes guided by structural or functional data compared with current clinical practice. Response to bronchial thermoplasty was determined from changes in airway responses to strong bronchoconstrictor simulations and flow heterogeneity after one or three simulated thermoplasty procedures. Structure-guided treatment showed significant improvement over current unguided clinical practice, with a single session of structure-guided treatment producing improvements comparable with three sessions of unguided treatment. In comparison, function-guided treatment did not produce a significant improvement over current practice. Structure-guided targeting of bronchial thermoplasty is a promising avenue for improving therapy and reinforces the need for advanced imaging technologies. The functional imaging-guided approach is predicted to be less effective presently, and we make recommendations on how this approach could be improved. NEW & NOTEWORTHY Bronchial thermoplasty is a recent treatment for asthma in which thermal energy is delivered via bronchoscope to specific airways in an effort to directly target airway smooth muscle. Current practice involves the treatment of a standard set of airways, unguided by patient-specific data. We consider the potential for guided treatments, either by functional or structural data from the lung, and show that treatment guided by structural data has the potential to improve clinical practice.

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Section: Discussionmentioning

confidence: 99%

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Donovan

Elliot

Boser³

et al. 2019

Journal of Applied Physiology

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“…123 Estimation of the birefringence and related polarization parameters (e.g., degree of polarization uniformity and optic axis orientation) represents an interesting alternative form of parametric imaging both with versions that integrate over similar axial regions as OCT attenuation imaging 72,132 and local versions. 133,134 Finally, retrieval of diattenuation-the polarization state-dependent differential attenuation-is also possible via PS-OCT but to the authors' knowledge is thought to be a small effect and has not yet been widely investigated. 135,136 Also based on polarization detection, Yashin et al 94 recently used crosspolarization OCT to simultaneously measure the attenuation coefficients of the co-and crosspolarized detected light.…”

Section: Complementary Optical Propertiesmentioning

confidence: 99%

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

et al. 2020

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Significance: Optical coherence tomography (OCT) provides cross-sectional and volumetric images of backscattering from biological tissue that reveal the tissue morphology. The strength of the scattering, characterized by an attenuation coefficient, represents an alternative and complementary tissue optical property, which can be characterized by parametric imaging of the OCT attenuation coefficient. Over the last 15 years, a multitude of studies have been reported seeking to advance methods to determine the OCT attenuation coefficient and developing them toward clinical applications. Aim: Our review provides an overview of the main models and methods, their assumptions and applicability, together with a survey of preclinical and clinical demonstrations and their translation potential. Results: The use of the attenuation coefficient, particularly when presented in the form of parametric en face images, is shown to be applicable in various medical fields. Most studies show the promise of the OCT attenuation coefficient in differentiating between tissues of clinical interest but vary widely in approach. Conclusions: As a future step, a consensus on the model and method used for the determination of the attenuation coefficient is an important precursor to large-scale studies. With our review, we hope to provide a basis for discussion toward establishing this consensus.

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“…The measurement of the Jones matrix offers a pathway to extract additional tissue contrast associated with birefringence, such as phase retardation, birefringence and optic axis orientation. [19][20][21][22][23] By more complex processing, such measurements may also be converted to be differential with depth, either within a given large (ie, many resolution cells) window 24 or locally (ie, depth-resolved, to a single or a few resolution cells). 22,23 The complete detection of polarized signals in PS-OCT provides as a minimum a more reliable OCT signal, by eliminating polarization fading, which may improve OCTA imaging.…”

Section: Due Tomentioning

confidence: 99%

Jones matrix‐based speckle‐decorrelation angiography using polarization‐sensitive optical coherence tomography

Gong

Wang

et al. 2020

Journal of Biophotonics

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We show that polarization‐sensitive optical coherence tomography angiography (PS‐OCTA) based on full Jones matrix assessment of speckle decorrelation offers improved contrast and depth of vessel imaging over conventional OCTA. We determine how best to combine the individual Jones matrix elements and compare the resulting image quality to that of a conventional OCT scanner by co‐locating and imaging the same skin locations with closely matched scanning setups. Vessel projection images from finger and forearm skin demonstrate the benefits of Jones matrix‐based PS‐OCTA. Our study provides a promising starting point and a useful reference for future pre‐clinical and clinical applications of Jones matrix‐based PS‐OCTA.

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Robust reconstruction of local optic axis orientation with fiber-based polarization-sensitive optical coherence tomography

Cited by 52 publications

References 44 publications

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Parametric imaging of attenuation by optical coherence tomography: review of models, methods, and clinical translation

Jones matrix‐based speckle‐decorrelation angiography using polarization‐sensitive optical coherence tomography

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