Robust Silica Aerogel Microspheres from Rice Husk Ash to Enhance the Dissolution Rate of Poorly Water-Soluble Drugs

Rajanna, Suresh Kumar; Vinjamur, Madhu; Mukhopadhyay, Mausumi

doi:10.1080/00986445.2016.1263618

Cited by 9 publications

(1 citation statement)

References 22 publications

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“…Furthermore, attention must be paid to the stability of the system, as the degradation of the colloid makes it toxic and may result in adverse reactions due to the high concentration of silicon in the body. (Suresh, 2017). Figure 1 shows the areas in which airgel can be applied, as well as its characteristics.…”

Section: Introductionmentioning

confidence: 99%

Rice Hulk Ash as an Alternative Source of Silica for the Production of Medicine Release Systems – A Review and New Perspectives

Nascimento,

Sousa,

Furtado

2023

JASR

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Rice husk ash (CCA) is a residue generated from burning the husk, obtained after processing rice, for energy generation, and may contain around 80 -98% w/w amorphous silica depending on the conditions of burn. Obtaining silica can be carried out through different processes, however, as it is extracted from industrial waste, with a renewable raw material source, it makes the process economically and ecologically viable. Amorphous silica has been applied in several areas of science and technology, however, due to its physical-chemical characteristics, biocompatibility and chemical inertness, work has been carried out using silica as vehicles for transporting medicines. Release systems aim to control the rate and time of release as well as the location of where the drug must act, thus increasing the efficiency and safety of therapeutic treatment, with the reduction of dosage and side effects, respectively. The systems are prepared by loading bioactive molecules into the system and are analyzed using various analytical techniques. In this review, a survey of publications focused on the production and characterization of silica particles was carried out with the aim of obtaining support for medicines. After analyzing fifteen articles, it was concluded that medicines have the ability to be adsorbed on amorphous materials or in dispersions. Colloidal solutions containing silica, more precisely airgel, are the most widely used medium, as they present requirements for an efficient drug release system, such as low density, high porosity and large specific area, resulting in high adsorption capacity and release control. of the drug, as well as greater efficiency in the interaction between the biological fluid and the polymeric matrix. Ibuprofen was used as a model drug to carry out studies on the loading and release efficiency of the devices. The studies were carried out exclusively on a laboratory scale.

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Section: Introductionmentioning

confidence: 99%

Rice Hulk Ash as an Alternative Source of Silica for the Production of Medicine Release Systems – A Review and New Perspectives

Nascimento,

Sousa,

Furtado

2023

JASR

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Fast Synthesis of Spherical Silica Aerogel Powders by Emulsion Polymerization from Water Glass

Lee

Kim²,

Lee³

et al. 2018

ChemistrySelect

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In this study, a fast synthesis technique for silica aerogel powder was proposed that reduces the length of the tedious surface modification and solvent exchange processes. Spherical silica aerogel powder could be fabricated by an emulsion polymerization method from water glass and n-hexane. A stable water glass-in-hexane emulsion with a water glass to hexane ratio of 5:5 was fabricated using the surfactant, sorbitan monooleate (Span80). It was found that acetic acid and isopropanol catalysts for the hydrolysis and condensation of water glass droplets dispersed in the emulsion were crucial for the synthesis of the spherical silica aerogel powder with a narrow particle size distribution and for reducing production time. In addition, the particle size of the spherical silica aerogel could be controlled by changing the water glass droplet size.A silica (SiO 2 ) aerogel is an ultra-porous (90-99% of theoretical density) material with a 3-dimensional network structure of silica nanoparticles. [1] Because of its interesting characteristics such as high specific surface area, low thermal conductivity, low dielectric constant, and low refractive index, it has received wide attention within various fields as a promising material for catalysis, [2,3] adsorption, [4,5] heat insulation [6,7] and drug delivery. [8"9] Silica aerogels are normally synthesized via a sol-gel route from silicon alkoxides such as tetramethylorthosilicate (TMOS) or tetraethylorthosilicate (TEOS). A silica wet gel is formed as a result of a hydrolysis and condensation process of the silicon alkoxide molecules. The silica aerogel can then be obtained by a supercritical drying process with carbon dioxide (CO 2 ). [10,11] However, the alkoxide-derived silica aerogels use expensive precursors, and the supercritical drying process requires long processing times (low heating and depressurization rates) [12,13] which increases the overall cost of the aerogel.Ambient pressure drying (APD) is another option to produce silica aerogel, and water glass-based silica aerogels by APD has been extensively studied by many researchers. [14][15][16][17] The APD relies on surface modification and solvent exchange processes that are not only tedious but also economically unfavorable. Since surface modification agents (typically, trimethylchlorosilane (TMCS) or hexamethyldisilazane (HMDS)) can be transported within the silica hydrogel only by diffusion, APD requires processing times longer than a few or sometimes even tens of hours. [14][15][16] Recently, some groups have attempted to reduce the processing time of APD via a co-precursor method. [18][19][20] Huber et al. proposed a one-pot synthesis technique for a silica aerogel granulate, which could reduce solvent use and production time to within 4 h. However, they used an expensive precursor like polyethoxysiloxane (PEDS), and the morphology of the synthesized silica aerogel granulate was irregular. [21] Pan et al. prepared a silica aerogel powder via APD from water glass within 4 h. [22] Although the mechanical cru...

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Biomedical applications of silica-based aerogels: a comprehensive review

et al. 2023

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Robust Silica Aerogel Microspheres from Rice Husk Ash to Enhance the Dissolution Rate of Poorly Water-Soluble Drugs

Cited by 9 publications

References 22 publications

Rice Hulk Ash as an Alternative Source of Silica for the Production of Medicine Release Systems – A Review and New Perspectives

Rice Hulk Ash as an Alternative Source of Silica for the Production of Medicine Release Systems – A Review and New Perspectives

Fast Synthesis of Spherical Silica Aerogel Powders by Emulsion Polymerization from Water Glass

Biomedical applications of silica-based aerogels: a comprehensive review

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