Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico

Licona-Enríquez, Jesús David; Mora, Jesús Delgado-de la; Paddock, Christopher D.; Ramirez-Rodriguez, Carlos Arturo; Candia-Plata, María del Carmen; Hernández, Gerardo Álvarez

doi:10.4269/ajtmh.16-0917

Cited by 19 publications

(10 citation statements)

References 27 publications

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“…Se sabe que, en estas dos enfermedades, están indicados antibióticos específicos que reducen la letalidad si se suministran de manera oportuna, idealmente en los primeros cinco días de la enfermedad. En algunos estudios se ha demostrado que la resolución de la enfermedad obedece a una intervención terapéutica rápida, incluso en presentaciones atípicas ( 20 , 21 ).…”

Section: Discussionunclassified

Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas

García

Quintero

Rosado³

et al. 2021

biomedica

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Se presenta el caso de un hombre de 50 años de edad proveniente de la región de Urabá, Colombia, con una infección mixta por Rickettsia rickettsii y Leptospira interrogans serovar Copenhageni ST78, y pruebas negativas para malaria y dengue.El paciente presentó un síndrome febril que no mejoró con el tratamiento antibiótico sistémico y, finalmente, falleció en la unidad de cuidados intensivos. El diagnóstico post mortem se hizo mediante tipificación molecular de los dos agentes etiológicos. En la inspección del domicilio del paciente, se encontró un ejemplar de Rattus rattus infectado con L. interrogans del mismo serovar detectado en él. No se encontraron garrapatas en los animales domésticos que habitaban con el paciente.Se reporta una infección mixta con síntomas clínicos progresivos y fatales en un paciente con antecedentes laborales de riesgo en una zona endémica para enfermedades tropicales, lo que obliga a tener presente la posibilidad de infecciones simultáneas en personas procedentes de áreas endémicas que consulten reiteradamente por síndrome febril sin resolución y tengan riesgo laboral relacionado con actividades agrícolas.

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Section: Discussionunclassified

Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas

García

Quintero

Rosado³

et al. 2021

biomedica

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“…All of the mothers survived and one child born by SVD at 36 weeks had an uncomplicated course. Three women in the first trimester had spontaneous abortions (41). The authors identify 10 patients in the literature including their four patients.…”

Section: Rickettsia Rickettseiimentioning

confidence: 99%

An Overview of Tickborne Infections in Pregnancy and Outcomes in the Newborn: The Need for Prospective Studies

Lambert

2020

Front. Med.

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Tick-borne infections are an ever-increasing issue internationally, many factors contribute to this including a changing climate. Pregnant women represent the single largest vulnerable group in populations due to a relative immune deficiency status. Infections in pregnant women have the added gravity of potential infection in the developing fetus which may have catastrophic consequences including death in-utero or lifelong debilitation. Currently there is a paucity of data surrounding tick-borne infections in pregnancy and long-term outcomes for mother and infant for conditions like Lyme disease and co-infections. At present there are no established international surveillance systems to identify and gain understanding of these infections in pregnancy. Furthermore, the removal of Congenital Lyme Disease from ICD-11 codes hampers dialogue and characterization of borreliosis in pregnancy and stifles future developments of this understudied domain. This review makes the case for further study and reopening a dialogue of tick-borne infections in pregnancy.

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“…A case series of four patients in Mexico treated with doxycycline for RMSF had bad outcomes, with three mothers having spontaneous abortions in the first trimester, the fourth was a full-term spontaneous vaginal delivery (SVD). 144 The authors identified 10 cases in the literature including their four patients. Doxycycline was used in five cases, chloramphenicol in three and amoxicillin in two.…”

Section: Rickettsia Rickettseiimentioning

confidence: 99%

Vector-borne diseases in pregnancy

O’Kelly

Lambert

2020

Therapeutic Advances in Infection

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Vector-borne infections cause a significant proportion of world-wide morbidity and mortality and many are increasing in incidence. This is due to a combination of factors, primarily environmental change, encroachment of human habitats from urban to peri-urban areas and rural to previously uninhabited areas, persistence of poverty, malnutrition and resource limitation in geographical areas where these diseases are endemic. Pregnant women represent the single largest ‘at risk’ group, due to immune-modulation and a unique physiological state. Many of these diseases have not benefitted from the same level of drug development as other infectious and medical domains, a factor attributing to the ‘neglected tropical disease’ title many vector-borne diseases hold. Pregnancy compounds this issue as data for safety and efficacy for many drugs is practically non-existent, precluding exposure in pregnancy to many first-line therapeutic agents for ‘fear of the unknown’ or overstated adverse pregnancy-foetal outcomes. In this review, major vector-borne diseases, their impact on pregnancy outcomes, current treatment, vaccination and short-comings of current medical practice for pregnant women will be discussed.

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Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico

Cited by 19 publications

References 27 publications

Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas

Leptospirosis y rickettsiosis, reto diagnóstico para el síndrome febril en zonas endémicas

An Overview of Tickborne Infections in Pregnancy and Outcomes in the Newborn: The Need for Prospective Studies

Vector-borne diseases in pregnancy

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