Rod and Cone a-Waves in Central Retinal Vein Occlusion

Tanimoto, Naoyuki; Usui, Tomoaki; Ichibe, Mikio; Takagi, Mineo; Suzuki, Keiko; Hasegawa, Shigeru; Abe, Haruki

doi:10.1007/s10384-004-0220-6

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…In an acute high intraocular pressure model of retinal ischemia, Brunette et al (1986) reported that during the rise in intraocular pressure cone function was more resilient to the effects of ischemia, but in the long term rod function recovered to higher levels, supporting our finding that rod bipolar cell function is less affected in the long term. Results from human patients with central retinal vein occlusion show variation, with some studies supporting a preferential loss in cone‐mediated function (Chen et al, 2006), and others showing no difference (Hayreh et al, 1989; Tanimoto et al, 2005). Patients with central retinal artery occlusion demonstrated a greater loss in rod‐mediated function (Machida et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Alterations in photoreceptor‐bipolar cell signaling following ischemia/reperfusion in the rat retina

Sun

Bui

Kalloniatis

2007

J of Comparative Neurology

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Studies of retinal ischemia/reperfusion indicate a disparity between the anatomical and functional results; while a large number of rod bipolar cells remain postischemia, there is a significant reduction in the amplitude of the scotopic b-wave of the electroretinogram (ERG). We investigated the alterations in photoreceptor-bipolar cell signaling following ischemia/reperfusion and suggest a mechanism for the decrease in b-wave amplitude. A cation channel probe (agmatine, 1-amino-4-guanidobutane, AGB) was used to assess cellular ion channel activity in neurochemically identified cells secondary to endogenous glutamate release or pharmacological manipulations. By applying the "neurochemical truth point" principle (Sun et al. [2007a] J Comp Neurol, this issue), we have been able to confirm the loss of specific subpopulations of neurons. ERG was used to assess gross retinal function, with parameters of the ERG model providing insight into changes in the phototransduction cascade and sensitivity of postreceptoral glutamate receptors. Following ischemia/reperfusion, rod bipolar cells maintained 2-amino-4-phosphonobutyric acid-responsive metabotropic glutamate receptors and displayed no change in sensitivity to flashes of light as assessed by ERG. Therefore, the loss in b-wave amplitude is likely due to alterations in photoreceptoral glutamate release detected as a change in postsynaptic AGB permeation into rod bipolar cells. Bipolar cell to amacrine cell signaling was also altered. The robust AGB entry into cholinergic amacrine cells was virtually absent in retinas that had undergone ischemia/reperfusion but remained in the AII amacrine cells. Such results suggest a loss of glutamate receptors and/or a change in receptor subunit expression in subpopulations of inner retinal neurons. Although many cells retain their characteristic neurochemical labeling following ischemia/reperfusion, caution should be used when assuming cells participate in functional retinal circuits based solely on the persistence of neurochemical labeling.

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Section: Discussionmentioning

confidence: 99%

Alterations in photoreceptor‐bipolar cell signaling following ischemia/reperfusion in the rat retina

Sun

Bui

Kalloniatis

2007

J of Comparative Neurology

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“…Such susceptibility is also supported by functional measures (the electroretinogram, ERG) from animal models of acute ischemia (Brunette, 1986;Blasco et al, 1997). However, ERG recordings from human patients with more subtle ischemia (central retinal vein occlusion) reveal no significant difference between cone versus rod mediated function (Hayreh et al, 1989;Tanimoto et al, 2005).…”

Section: Preferential Loss Of Theme Classesmentioning

confidence: 96%

Metabolic and functional profiling of the ischemic/reperfused rat retina

Sun

Vingrys

Kalloniatis

2007

J of Comparative Neurology

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We quantitatively tracked the recovery in amino acid labeling and cation channel functionality within distinct retinal elements for up to 2 weeks after an ischemic insult. Pattern recognition analysis of multiple amino acid and agmatine (a cation channel probe; 1-amino-4-guanidobutane; AGB) immunocytochemical patterns was used to classify all neural elements within the retina. This classification was spatially complete and with single-cell resolution. By 48 hours of reperfusion the amino acid labeling pattern of virtually all cell populations had returned to near preischemic levels, with the exception of glutamine and alanine levels, which remained significantly higher in many cell populations. Classification resulted in a total of 18 statistically separable theme classes (including neurons, glia, and extraretinal classes), a reduction of 10 theme classes from the normal retina (Sun et al. [ 2007a, b] J Comp Neurol, this issue). In addition to the known selective losses of amacrine cell types within the inner nuclear layer, we now demonstrate a selective loss of theme classes representing cone bipolar cells within the bipolar cell population. While there was a recovery in the amino acid labeling pattern, there were persistent cation channel gating anomalies (as reflected by AGB labeling) within several theme classes, including the theme class representing all the remaining rod bipolar cells, suggesting aberrant neuronal function secondary to metabolic insult.

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Intravitreal Injections of Ziv-Aflibercept for the Treatment of a Patient With Macular Edema Secondary to Branch Retinal Vein Occlusion

Andrade

Dias

Maia

et al. 2018

RETINAL Cases &Amp; Brief Reports

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Intravitreal injections of ziv-aflibercept showed both effectiveness and safety in the treatment of a patient with macular edema secondary to branch retinal vein occlusion. The observed anatomic (by ophthalmic examination, optical coherence tomography) and functional (best-corrected visual acuity, full-field electroretinography) improvements and lack of serious adverse side effects demonstrates the potential of intravitreal injections of ziv-aflibercept for the treatment of macular edema secondary to branch retinal vein occlusion.

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Rod and Cone a-Waves in Central Retinal Vein Occlusion

Abstract: The change in the phototransduction cascade was confirmed not only in rods but also in cones in five of our seven cases of CRVO. The ERG findings might reflect the functional change in the photoreceptor layer after the onset of CRVO.

Cited by 3 publications

References 25 publications

Alterations in photoreceptor‐bipolar cell signaling following ischemia/reperfusion in the rat retina

Alterations in photoreceptor‐bipolar cell signaling following ischemia/reperfusion in the rat retina

Metabolic and functional profiling of the ischemic/reperfused rat retina

Intravitreal Injections of Ziv-Aflibercept for the Treatment of a Patient With Macular Edema Secondary to Branch Retinal Vein Occlusion

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