Rod-like l-Aspartic acid-Cu(II) metal organic frameworks; Synthesis, characterization and biomedical properties

Gizer, Gorkem; Şahiner, Mehtap; Yildirim, Yıldız; Demirci, Şahin; Can, Mehmet; Şahiner, Nurettin

doi:10.1016/j.crgsc.2021.100110

Cited by 21 publications

(11 citation statements)

References 78 publications

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“…The appearance of the band at 3363 cm −1 may be attributed to N–H stretching modes, suggesting that the amino N atom is also coordinated with the metal ion. 27 FT-IR peaks observed at around 606, 754, and 2922 cm −1 , represent the bonding between Zn–O and C–H 28 ( Fig. 2 ).…”

Section: Resultsmentioning

confidence: 99%

Novel aspartic-based bio-MOF adsorbent for effective anionic dye decontamination from polluted water

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Novel aspartic-based bio-MOF adsorbent for effective anionic dye decontamination from polluted water

et al. 2022

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“…Two peaks at 1139 cm −1 and 1118 cm −1 were related to NH 2 rocking mode. 10 All the peaks were corresponding to the presence of carboxyl and amine groups in L-aspartic acid.…”

Section: Optimization and Validationmentioning

confidence: 99%

“…3a exhibited a rod-like shape with several micrometers in length and a diameter of 80 to 180 nm, which is slightly smaller than the reported literature. 10,22,[34][35][36] This might be due to the slow crystallization process of the amino acid-based MOF. 37 This structure is the most promising among one-dimensional nanostructures owing to its high surface-to-volume ratio and web-like conguration, 34 which are advantageous for rGO attachment and lipase immobilization.…”

Section: Optimization and Validationmentioning

confidence: 99%

“…This nding is consistent with the previous literature. 10,33,34 There is also a possibility of the copper ion coordination with the amine group due to the shiing of the overlapping bands of the N-H stretch and O-H stretch. 34 Thus, the Cu-MOF can be formed via a coordination bond between the copper ion with the carboxyl group only, or with the carboxyl and amine groups of the L-aspartic acid.…”

Section: Optimization and Validationmentioning

confidence: 99%

“… 9 It is also beneficial owing to its biocompatibility as it employs amino acid as the ligand. 10 However, MOFs possess poor electroconductivity and catalytic activity, which is a problem in electrochemical sensors. 11 The integration with reduced graphene oxide (rGO) with superior electrochemical and thermal conductivity can overcome these limitations.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of a lipase/reduced graphene oxide/metal–organic framework electrode using a central composite design-response surface methodology approach

2023

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Bio‐MOFs Based on Natural Phenolic, Hematoxylin Leverages Biomedical Applications: Enzyme Inhibition, Antioxidant, and Antibacterial Properties

Sahiner,

Tian,

Demirci

et al. 2024

Chemistry & Biodiversity

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Here, using natural hematoxylin (HT) as linker, metal‐organic frameworks (MOFs) from Cu(II), Fe(II), and Fe(III) ions was prepared. The SEM images and DLS analyses revealed HT‐based MOFs are <micrometer sizes with the highest surface area value of 49.2 m2/g for HT‐Fe(III) MOFs. Interestingly, HT‐based MOFs exhibit fluorescent properties at λem=330 nm with fluorescence intensities of 11485, 2120, and 6790 (a.u) for HT‐Cu(II), Fe(II), and Fe(III) MOFs, respectively. Moreover, HT‐based MOFs inhibited α‐glucosidase enyzme in a concentration‐dependent manner e.g., 33.1%, 69.8%, and 59.7% of Cenzyme=500 mg/mL was inhibited by HT‐Cu(II)‐MOF, HT‐Fe(II)‐MOF, and HT‐Fe(III)‐MOFs, respectively. The minimum bactericidal concentration (MBC) values of HT‐Cu(II) MOFs for Escherichia coli (gram ‐), Staphylococcus aureus (gram +), and Candida albicans are determined as 5, 5, and 10 mg/mL, respectively. Also, the antioxidant activities of 250 ppm HT‐based MOF based on total phenol content (TPC) tests revealed 279, 208, 124, and 152 mg.gallic acid equivalent/mL (mg GA equivalency/mL) for HT, HT‐Cu(II) MOF, HT‐Fe(II) MOF, and HT‐Fe(III), respectively affirming that antioxidant properties were retained. Moreover, HT‐Fe(II) and HT‐Fe(III) MOFs (62.5 µg/mL) against human null‐1 lung cell line revealed cell viabilities of 98.7±12.2% and 88.9±11.7%, respectively as concentration‐dependent biocompatibility of MOFs.

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Rod-like l-Aspartic acid-Cu(II) metal organic frameworks; Synthesis, characterization and biomedical properties

Cited by 21 publications

References 78 publications

Novel aspartic-based bio-MOF adsorbent for effective anionic dye decontamination from polluted water

Novel aspartic-based bio-MOF adsorbent for effective anionic dye decontamination from polluted water

Optimization of a lipase/reduced graphene oxide/metal–organic framework electrode using a central composite design-response surface methodology approach

Bio‐MOFs Based on Natural Phenolic, Hematoxylin Leverages Biomedical Applications: Enzyme Inhibition, Antioxidant, and Antibacterial Properties

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