Rodaplutin, a new peptidylnuleoside from Nocardioides albus.

Dellweg, Hansgeorg; Kurz, Jürgen; Pflüger, Wolfgang; Schedel, Michael; Vobis, Gernot; Wünsche, Christian

doi:10.7164/antibiotics.41.1145

Cited by 21 publications

(5 citation statements)

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“…The nucleosides that have been screened for insecticidal activity are typically of the pyrimidine, purine and pyrimidinone type, and include clitocine, ( E )‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU), cordycepin, thuringiensin and rodaplutin. Moreover, these substances have demonstrated potent effects on, for example, Pectinophora gossypiella (Saunders) (pink bollworm), Spodoptera frugiperda (JE Smith) (fall armyworm), Plutella xylostella (diamondback moth), Lygus hesperus (Linnaeus) (lygus bug), Panonychus ulmi (Koch) (European red mite), Phaedon cochlearia (Fabricius) (mustard beetle) and Myzus persicae (Sulzer) (peach‐potato aphid), as well as on Tetranychus urticae (Koch) (two‐spotted spider mite) 12–17…”

Section: Introductionmentioning

confidence: 99%

Ribavirin, a nucleoside with potential insecticidal activity

Liu

Zhang

Feng

et al. 2012

Pest Management Science

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Section: Introductionmentioning

confidence: 99%

Ribavirin, a nucleoside with potential insecticidal activity

Liu

Zhang

Feng

et al. 2012

Pest Management Science

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“…No antimicrobial compound yet reported from this strain as detected in our strain EA85. Similarly other strain EA87 has close relatedness to Nocardioides albus KCTC 9186 T. This strain of Nocardioides is already known for production of antimicrobial compounds such as rodaplutin (Dellweg et al, 1988). Bioactive compounds detected in strain EA87 are different and not reported before.…”

Section: Discussionmentioning

confidence: 84%

Research Article LC-MS based identification of secondary metabolites from marine antagonistic endophytic bacteria

Bibi¹,

Naseer²,

Yasir³

et al. 2018

Genet. Mol. Res.

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Halophytes occupy coastal and sub-coastal area of marine environment. They potential candidates for search of novel and new bacterial flora that have immense potential to yield novel therapeutic agents. Six different endophytic bacteria have been isolated from pneumatophores and roots of three halophytes (Salsola imbricata, Avicennia marina and Haplopeplis perfoliata) collected from western coastal area of Jeddah, Saudi Arabia. After testing against five fungal pathogens all were active against oomycetes fungal pathogens, Phytophthora capsici and Pythium ultimum. Molecular identification of the bacteria was done on the basis of 16S rRNA gene sequences which revealed 95.9-99.4% sequence identity to related type strains and were placed in four major genera and two major classes: Actinobacteria (Streptomyces and Nocardioides) and α-Proteobacteria (Inquilinus and Labrezia). Active metabolites of these six bacterial endophytes including EA61, EA83, EA85, EA87, EA97 and EA220 were identified by subjecting to chemical analyses using liquid chromatography-mass spectrometry (LC-MS). LC-MS analyses showed presence of different active compounds in the culture extracts of these isolates. Some of these metabolites are already reported as synthetic molecules and has diverse biological functions as antimicrobial, anti-inflammatory and anthelmintic compounds such as such as Sulfamethoxypyridazine, Sulfamonomethoxine, Sulfamerazine and Dimetridazole, Sulfadiazin. Genetics and Molecular Research 17 (1): gmr16039857 Bibi F, et al. 2 Nalidixic acid and Oxibendazole. This study provides an insight into potential bacterial flora of halophytes producing bioactive metabolites of medical significance.

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“…alt-text: Dellweg et al, 1988;Shashkov et al, 1999) MOLA1528 (Matsuyama et al, 1999) a Putative new species based on 16S rRNA gene sequence analysis (identity ≤ at 97%); NF: not found.…”

Section: Tablementioning

confidence: 99%

Chemical analysis of the Alphaproteobacterium strain MOLA1416 associated with the marine lichen Lichina pygmaea

et al. 2018

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Alphaproteobacterium strain MOLA1416, related to Mycoplana ramosa DSM 7292 and Chelativorans intermedius CC-MHSW-5 (93.6% 16S rRNA sequence identity) was isolated from the marine lichen, Lichina pygmaea and its chemical composition was characterized by a metabolomic network analysis using LC-MS/MS data. Twenty-five putative different compounds were revealed using a dereplication workflow based on MS/MS signatures available through GNPS (https://gnps.ucsd.edu/). In total, ten chemical families were highlighted including isocoumarins, macrolactones, erythrinan alkaloids, prodiginines, isoflavones, cyclohexane-diones, sterols, diketopiperazines, amino-acids and most likely glucocorticoids. Among those compounds, two known metabolites (13 and 26) were isolated and structurally identified and metabolite 26 showed a high cytotoxic activity against B16 melanoma cell lines with an IC 0.6 ± 0.07 μg/mL.

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Rodaplutin, a new peptidylnuleoside from Nocardioides albus.

Cited by 21 publications

References 5 publications

Ribavirin, a nucleoside with potential insecticidal activity

Ribavirin, a nucleoside with potential insecticidal activity

Research Article LC-MS based identification of secondary metabolites from marine antagonistic endophytic bacteria

Chemical analysis of the Alphaproteobacterium strain MOLA1416 associated with the marine lichen Lichina pygmaea

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